DRSC/TRiP Functional Genomics Resources

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Protein Alignment shg and CDHR2

DIOPT Version :10

Sequence 1:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster
Sequence 2:NP_060145.3 Gene:CDHR2 / 54825 HGNCID:18231 Length:1310 Species:Homo sapiens


Alignment Length:1117 Identity:244/1117 - (21%)
Similarity:413/1117 - (36%) Gaps:297/1117 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 AGYAPK---------VKEEQPENTYVLTVEAVDPDPDQVIRYSIVQSPFERPK---FFINPSTGV 143
            |..|||         :.|:.|.......:.|.|.|.|. :.|.:     ..|.   |.:.|.||.
Human    20 ANVAPKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDP-LTYGM-----SGPNAYFFAVTPKTGE 78

  Fly   144 IFTTHTFDRDEPIHEKFVF-VTVQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDESMSEN 207
            :......|.:    ..:.| ||:..:|   |.:.......|.:||.|||||.|....:..|::|.
Human    79 VKLASALDYE----TLYTFKVTISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINET 136

  Fly   208 AQPDAVVMTISASDFDDGNNSLVEYEILR----ERDFQY-FKIDKESGIIYLKRPIDKRPGQSYA 267
            ....:||.::.|.|.|.|:..:|.|.|.:    ..|.:: |:| ..:|.|.|...:         
Human   137 LPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSL--------- 191

  Fly   268 IIVRAYNVVPDPPQDAQIEVRIRVVE-SSIKPPSFVNPIDTPIYLKENLKNFTHPIATLRAVSNM 331
                :||     .:.|..::.::..: ..:...:|......|::|.             .:|.:.
Human   192 ----SYN-----NKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLS-------------ISVVDQ 234

  Fly   332 PD-KPEVIFELNTGRTEQTNSKNTFVFN---------------------------QIGNEVTISL 368
            || .|:.:.|..:....:..:|.|.|..                           .||.:..|.:
Human   235 PDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRV 299

  Fly   369 GKTLD----YEAITDYTLTMIVRNTH--ELGTEHQIKI----QVEDVNDNIPYYTEVK------- 416
            ..:||    .||..:..|.:....||  ..|.|.::.|    :|.||||:.|.:....       
Human   300 NGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFT 364

  Fly   417 --------SGTILENEPPGTPV--MQVRAFDMD-GTSANNIVSFELADNREYFTIDPNTG----- 465
                    :|.:.|:..|..|:  :.:..:|.| |::...::|....| .|.|::.|...     
Human   365 PEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPD-AEAFSVSPERAVGSAS 428

  Fly   466 -----NITALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQD 525
                 .::||..::|:..  ..|:|:|:|:.        ..|....:..|.:.|.|||:|.|.|.
Human   429 VQVLVRVSALVDYERQTA--MAVQVVATDSV--------SQNFSVAMVTIHLRDINDHRPTFPQS 483

  Fly   526 KYLAERLLEDANTNTEVIE-VKAEDEDNAS--QILYSIESGNVGDAFKIGLKTGKITV--NQKLD 585
            .|:. .:.|.:.|.:.|.: :.|.|.|..:  ||.||:..||..|.|::...:|.:||  .:.||
Human   484 LYVL-TVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLD 547

  Fly   586 YETITEYELKVRAFD-GIYDDYTTVVIKIEDVNDNPPVFKQDYSVTILEETTYDDCILTVEAYDP 649
            .|:...|.|.::|.| |.....||:.|.:.|:|||.||....|::.:.||.  .:..:|::|:|.
Human   548 RESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVVSGSYNIFVQEEE--GNVSVTIQAHDN 610

  Fly   650 DIKDRNADQHIVYSIHQNDGNRWTID-NSGCLRLVKTLDR---DPP-NGHKNWQVLIKANDEDGV 709
            |....|..:.:...:.....:.:::| ::|.||.:..|||   ||. .|.....||:....|..:
Human   611 DEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVL 675

  Fly   710 GTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVV-QLQANDYDDTPGAGNFTFGIDS 773
            ||.|:    ||:|::|||||.|........:..:..:||.:| .::|.|.|.|......:|.:..
Human   676 GTKVN----VTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRISFSLSG 736

  Fly   774 EATPDIKTKFSMDGDYLHA-----------NVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLV 827
            ...    ..|.:.|..|.|           :|..|.|.|..:  .:.:|......|...:|:.:.
Human   737 SGA----NYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVF--NLTVSAENPDPQGGETIVDVC 795

  Fly   828 IG--DVNDN------------AMSEGSSR-------------------IFIYNYKGEAPETDI-- 857
            :.  |||||            .::|..|:                   |.:.|........|:  
Human   796 VNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGS 860

  Fly   858 -----------GRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSF-- 909
                       |.|:::.....|.|                  :..::|::|...:...|..|  
Human   861 LCWGWFSVAANGSVYINQSKAIDYE------------------ACDLVTLVVRACDLATDPGFQA 907

  Fly   910 --------VVTED-----SMFVPRHSVDAYVTVVVRELPEEAV-------DKSGS--IRFINVTK 952
                    :..||     ..|:|.:.  .:|.:....||...|       |.||:  :...::.:
Human   908 YSNNGSLLITIEDVNDNAPYFLPENK--TFVIIPELVLPNREVASVRARDDDSGNNGVILFSILR 970

  Fly   953 EEFISVPRDFQSPDALSLKDRLQLSLAKLFN--TSVSNVDVF-----------TVLQNENHTLDV 1004
            .:|||             ||...:....:|:  || |..|||           :.||.   |..|
Human   971 VDFIS-------------KDGATIPFQGVFSIFTS-SEADVFAGSIQPVTSLDSTLQG---TYQV 1018

  Fly  1005 RFSAHGSPYYAP 1016
            ...|...|...|
Human  1019 TVQARDRPSLGP 1030

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637 25/110 (23%)
Cadherin_repeat 200..292 CDD:206637 20/96 (21%)
CA 332..410 CDD:214520 25/115 (22%)
Cadherin_repeat 417..518 CDD:206637 23/113 (20%)
Cadherin_repeat 531..619 CDD:206637 30/93 (32%)
Cadherin_repeat 627..729 CDD:206637 30/106 (28%)
Cadherin_repeat 736..834 CDD:206637 22/111 (20%)
LamG 1127..1294 CDD:238058
CADH_Y-type_LIR 1430..1489 CDD:460041
CDHR2NP_060145.3 Cadherin_repeat 32..120 CDD:206637 22/100 (22%)
Cadherin_repeat 129..236 CDD:206637 24/138 (17%)
Cadherin_repeat 246..349 CDD:206637 20/102 (20%)
Cadherin_repeat 372..476 CDD:206637 23/114 (20%)
Cadherin_repeat 485..582 CDD:206637 31/97 (32%)
Cadherin_repeat 589..691 CDD:206637 30/107 (28%)
Cadherin_repeat 699..804 CDD:206637 22/110 (20%)
CA <864..926 CDD:214520 10/79 (13%)
Cadherin_repeat 935..1044 CDD:206637 26/113 (23%)
Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000269|PubMed:24725409 1180..1310
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1259..1310
Blue background indicates that the domain is not in the aligned region.

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