DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Cad86C

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_001247033.1	Gene:	Cad86C / 41302	FlyBaseID:	FBgn0261053	Length:	1949	Species:	Drosophila melanogaster

Alignment Length:	1500	Identity:	293/1500 - (19%)
Similarity:	469/1500 - (31%)	Gaps:	572/1500 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 HLNPAQQQTHQQHKRKCRDLGRRLIPARLLLGVIVA-----ISLLSPALALH--SPPDKNFSGDN 82
            |.:..|||.:.|:::.......||.|....||.:.|     ||||...|..|  ...|..|....
  Fly    82 HHHHHQQQHNHQNQQMQHHWPSRLGPIGPWLGAMTAYRLLTISLLIGILCPHHVQGADPKFDPTT 146

  Fly    83 RK-----PAFKNCAGYAPKVKEEQPENTYVLTVEAVDPDPDQVI--------------------- 121
            |.     ||.........:::....|..|.||.|.|.......:
  Fly   147 RMRLVLVPADAQVNSVIYRLRATDEEFDYPLTFEFVGDASASTVKVESLPCTKYNSVCQANIVLQ 211

  Fly   122 ------RY-------------------SIVQSPFERPKFFINP-STGVIF----------TTHTF 150
                  ||                   ||..:.|..|...|.| ..|:|.          ..:..
  Fly   212 RRLEPGRYYDFQVSVKDTKGGMTTQLCSITATNFTTPHDLIFPHKPGIIMIPEDAKRGTELDYVI 276

  Fly   151 DRDEPIHEKFVFV------------------TVQATDNGLPPLD--DVCTFNVTI---------- 185
            .|..|:.:|.|::                  |.:.|...|.|||  ....:::||
  Fly   277 ARKNPLFQKPVYLELWGSPLFAIRQKIVSSETTEGTVFLLGPLDFEKQAMYHLTILANDAYAEPG 341

  Fly   186 ---------------EDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDDGNNSLVEYEIL 235
                           :|:.|..|.|..|.....:.....|...::.:.|.|.|.||...|.|.::
  Fly   342 QDSRNIAGMEIVVIVQDVQDQPPVFTSAPPVTKLPPGILPGDKILQVHAEDGDKGNPREVRYGLV 406

  Fly   236 RERD--FQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPDPPQDAQIEVRIRVVESSIK- 297
            .|.:  ..:|.|::.||.|:|.||:     :..|.|..    |.||       |.:.|:...:|
  Fly   407 SENNPFTSFFDINETSGEIFLMRPL-----EDIAFITH----VGDP-------VLLTVIAEEVKV 455

  Fly   298 ----PPSFVNPIDTPIYLKENLKN---FTHPIATLRAVSNMPD-------KPEV--IFELNTGRT 346
                ||:..:.:....:|.:...:   |.:.....|...|.|.       .|.|  :::.:||:.
  Fly   456 GRDEPPALASTVQLAFFLPDRTNSPPYFENDHYVSRVDENAPHGTALTFVDPYVPRVYDDDTGKN 520

  Fly   347 -----EQTNSKNTFVFN------QIGNEVTISLGKTLDYEAITDYTLTMIVRNTHELGTEH---- 396
                 ...|:..||..:      ..|..:.:.....||||........::.:   |||...
  Fly   521 GVFSLTLLNNNGTFEISPNVAERSAGFLIRVRDNSMLDYEQQQSVQFQILAQ---ELGPATNLSA 582

  Fly   397 --QIKIQVEDVNDNIPYYTE-VKSGTILENEPPGTPVMQVRAFDMD----------------GTS 442
              .:.:.:.|||||.|.:.: ..|..:.||...||.|:||.|.|.|                .||
  Fly   583 LVNVTVYINDVNDNAPVFEQPAYSVELPENMTAGTKVVQVLATDPDSGLGGKVRYTAILGYLNTS 647

  Fly   443 ANNIVSFELADNREYFTIDPNTGNITALTT---FDREERDFYNVKVIASDNSPSSLFDNGEPNRG 504
            .|               :|..||.||..|.   ||||....|::.|.|.|.       :||.||.
  Fly   648 LN---------------LDAETGLITVSTNKHGFDREVMPEYHLYVEARDM-------DGEGNRA 690

  Fly   505 HQVFRISIGDKNDHKPHFQQDKY---LAERLLEDANTNTEVIEVKAEDEDNA---SQILYSIESG 563
            .....|.:.|.||..|.|.:|.|   |...|:  ..|.|.||.  |||:|..   :::.|.|.:|
  Fly   691 QVPLIIKLIDVNDETPIFDKDLYEFILTHDLM--GFTTTAVIH--AEDKDATAPNNEVRYEIING 751

  Fly   564 NVGDAFKIGLKTGKITVNQKL------------------DYETITEYELKVRAFD-GIYDDYTTV 609
            |..:.|.:...||::||.:|:                  |.|....:.|..||:| |:...::|.
  Fly   752 NYDNQFVLDKVTGELTVREKIHLRSKKNAKTRRRRQAGSDDEDTDIFILTARAYDLGVPVRFSTT 816

  Fly   610 VIKIEDVND------------NPPVFKQDYSVTIL---------------EETTYDDCILTVEAY 647
            .|::.....            ||...|.:.:::.|               :|....|    :.|.
  Fly   817 TIRVYPPESRKRSVKFVVPGHNPDKAKTEETLSALSGGKVYIHNIRPLSPDEPGAKD----IPAG 877

  Fly   648 DPDIKDRNA-------DQHIVYSI--------HQNDG------------------NRWTIDN--- 676
            :|.||:|:.       |...|..|        |.|:.                  .::..:|
  Fly   878 NPGIKERSVVTATVIYDSSSVVDISEIQQRLSHHNNSYAIMPQDTSSTDTLTPLQTQYKAENKVL 942

  Fly   677 ------------------------SGC----------LRLVKTLD------RDPPNGHKNWQVLI 701
                                    |.|          :.:.:|.|      |:..||.:...|.:
  Fly   943 FWLLILLATLVALTILILLLCCICSWCPLYGAATKRIVNISRTEDDVHLVHREMANGKQTKSVQV 1007

  Fly   702 -------------------------------KANDED-GVGTTV------------STVKEVTV- 721
                                           :..||| |.|..:            ...:.|.:
  Fly  1008 AEWMGRRDAWSAEKPPDTRTKPTRWEFHDGREQLDEDVGRGQDIGEGDRRHIQSAEEQQRRVRIK 1072

  Fly   722 ---TLKD-----INDNAPFLINEMPVYWQ---ENRNPG----HVVQLQAN--DY----------- 758
               |.||     .:::...|||:..||.:   |||:..    |:.:.:.|  :|
  Fly  1073 HNRTAKDDLHLNFHNSRTNLINDRDVYMEDVIENRDLAGDREHITRTRVNRQEYARRKQYDSEVR 1137

  Fly   759 --DDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAV 821
              ||           ||....:|.....:|.:..|.::    ::::|.||          :...|
  Fly  1138 HIDD-----------DSMRRHEIDRGSDIDFNTAHNSL----KSKRELFI----------KDGNV 1177

  Fly   822 SILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFR 886
            .||.|:..|...:.::.....|::     ..|....|                    :|.|.|..
  Fly  1178 EILQLMTRDKTRDGLNLDDDNIYV-----NVPLKPAG--------------------NLSHPQLL 1217

  Fly   887 LNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEA------------V 939
            :..:||...::....|.:.|...::.|....||.       ...::.:|.|.            :
  Fly  1218 MVDNTGKEILMRRFIEEQPDGKQIIREHYQIVPG-------ATYIQSMPNEVQQGSTLKGDTFPL 1275

  Fly   940 DKSG--SIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTL 1002
            .|||  ||.:..:..|..:...:..|:.:.:||..::|        .:|||       |:..|.|
  Fly  1276 GKSGPNSIVYSQLEPEVKVIHTQPVQAGEGVSLDQQMQ--------PAVSN-------QSLTHEL 1325

  Fly  1003 DVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVP 1067
                                  ::..:.:|.|..|:||        ||.|.|.:.|.  |:.::
  Fly  1326 ----------------------EHSLKQQNALLRQILM--------EKEKLENAYTQ--HEVAL- 1357

  Fly  1068 YMIYSNTTSFVGVNAFVQAQCVCEA-------------------PLMRRCLNGGSPRYGENDVCD 1113
                 .|.|..|.:..:..|..|:|                   |..||..:       |||...
  Fly  1358 -----ETQSLPGQSMAIGTQTDCDAGTQTEGFDGVLDPEISLAKPSRRRARS-------ENDESM 1410

  Fly  1114 CIDGF 1118
            ..||:
  Fly  1411 SEDGY 1415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637	29/199 (15%)
		Cadherin_repeat	200..292	CDD:206637	23/93 (25%)
		CA	332..410	CDD:214520	21/103 (20%)
		Cadherin_repeat	417..518	CDD:206637	35/119 (29%)
		Cadherin_repeat	531..619	CDD:206637	28/121 (23%)
		Cadherin_repeat	627..729	CDD:206637	31/245 (13%)
		Cadherin_repeat	736..834	CDD:206637	23/119 (19%)
		LamG	1127..1294	CDD:238058
		Cadherin_C	1358..1489	CDD:279398
Cad86C	NP_001247033.1	Cadherin_repeat	260..361	CDD:206637	14/100 (14%)
		Cadherin_repeat	372..469	CDD:206637	27/112 (24%)
		Cadherin_repeat	487..596	CDD:206637	21/111 (19%)
		Cadherin_repeat	605..703	CDD:206637	34/119 (29%)
		Cadherin_repeat	728..820	CDD:206637	25/93 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24026
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100