DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Cdh20

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_001012766.1	Gene:	Cdh20 / 363948	RGDID:	1305438	Length:	801	Species:	Rattus norvegicus

Alignment Length:	1279	Identity:	247/1279 - (19%)
Similarity:	385/1279 - (30%)	Gaps:	626/1279 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 VSNMPDKPEVIFELNT---GRTE-QTNSKNTFVFNQI---------------------------- 360
            :|:.| .|||  ||:|   |:.: ...|:.::|:||.
  Rat    33 LSSTP-MPEV--ELDTLFSGKPQSHQRSRRSWVWNQFFVLEEYTGTDPLYVGKLHSDMDRGDGSI 94

  Fly   361 -------GNEVTISLGKT---------LDYEAITDYTL---TMIVRNTHELGTEHQIKIQVEDVN 406
                   |..:..::..|         ||.|....|||   .:..|....:..|.:..|:::|:|
  Rat    95 KYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFIIKIQDIN 159

  Fly   407 DNIPYYTE-VKSGTILENEPPGTPVMQVRAFDMD----GTSANNIVSFELADNREYFTIDPNTGN 466
            ||.|.:.: ....|:.|..|.||.|:||.|.|.|    |.||.  |.:.:...:.||::|..||.
  Rat   160 DNEPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSAR--VVYSILQGQPYFSVDSKTGI 222

  Fly   467 I-TALTTFDREERDFYNVKVIASDNSPSSLFDNGEPN--RGHQVFRISIGDKNDHKPHFQQDKYL 528
            | |||...|||.:::|.|.:.|.|.       .|:..  .|.....|::.|.||:.|.|.| |:.
  Rat   223 IRTALMNMDREAKEYYEVIIQAKDM-------GGQLGGLAGTTTVNITLSDVNDNPPRFPQ-KHY 279

  Fly   529 AERLLEDANTNTEVIEVKAEDEDNA--SQILYSIESGNVGDAFKI----GLKTGKITVNQKLDYE 587
            ...:||.|..::.|..|.|:|.|..  :::.|:|..|:..|||.|    ..:.|.|||.:.|.:|
  Rat   280 QMSVLESAPVSSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDINTDPNFQVGIITVKKPLSFE 344

  Fly   588 TITEYELKVRAFD----------GIYDDYTTVVIKIEDVNDNPPVFK-QDYSVTILEETTYDDCI 641
            :...|.|||...:          |.:.|.|||.|.:||| |.||||: :.|.|.:.|:.|....|
  Rat   345 SKKSYTLKVEGSNPHVEMRFLNLGPFQDTTTVHIIVEDV-DEPPVFEPRFYFVEVPEDVTIGTTI 408

  Fly   642 LTVEAYDPDIKDRNADQHIVYSIHQ--NDGNRWTID-NSGCLRLVKTLDRDPPNGHKNWQVLIKA 703
            ..:.|.|||:.:.:    |.|||.:  :.|..:.:| .:|.|...:.|||:..:.|....:.::.
  Rat   409 QIISAKDPDMTNNS----IRYSIDRGSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEM 469

  Fly   704 NDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQ----ENRNPGHVVQ-LQANDYDDTPG 763
            |:...||:..:|:|     :.|:|||||    |.|.:::    ||...|.::| :.|.|.||...
  Rat   470 NNPSQVGSVAATIK-----VLDVNDNAP----EFPRFYEAFICENAKAGQLIQTVSAVDQDDPHN 525

  Fly   764 AGNFTFGIDSEA--TPDIKTKFSMDGD--YLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSIL 824
            ..:|.:.:..||  .|:...:.:.|..  .|.....|.::.|..:::||.|:|||.|..|
  Rat   526 GQHFYYSLAPEAANNPNFTVRDNQDNTARILTRRSGFRQQEQSVFYLPILIADSGQPVLS----- 585

  Fly   825 HLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNP 889

  Rat   586 ----------------------------------------------------------------- 585

  Fly   890 STGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEE 954
            |||.:|:
  Rat   586 STGTLTI---------------------------------------------------------- 592

  Fly   955 FISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKL 1019

  Rat   593 ----------------------------------------------------------------- 592

  Fly  1020 NGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFV 1084

  Rat   593 ----------------------------------------------------------------- 592

  Fly  1085 QAQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKI 1149
                                     .||.|
  Rat   593 -------------------------QVCSC----------------------------------- 597

  Fly  1150 SLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRT 1214
                                              .|:|                  |:...:...
  Rat   598 ----------------------------------SDDG------------------HVMSCSPEA 610

  Fly  1215 YQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVP 1279
            |.|.:.|.|                  ||
  Rat   611 YMLPVSLSR------------------GA------------------------------------ 621

  Fly  1280 NQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCL-ALLLII 1343
                                                              :|||:.|: .||:::
  Rat   622 --------------------------------------------------LIAILACVFVLLVLV 636

  Fly  1344 LLAVVVQKKQKNGWHEKDIDDIRETIINYEDEGGGERDTD-YDL----NVLRTQPFYEEKLYKDP 1403
            ||.:.:::.:|..:...|.::|.|.|:.|:||||||.||: :|:    |....|.....|..:|.
  Rat   637 LLILSMRRHRKQPYIIDDDENIHENIVRYDDEGGGEEDTEAFDIAAMWNPREAQAGAAPKTRQDM 701

  Fly  1404 HALQGNMRDPNDIPDIADFLGDKKENC-----------------DRDVGATTVDDVRHYAYEGDG 1451
                        :|:|........:.|                 |.|:.|...|.::.|.:||||
  Rat   702 ------------LPEIESLSRYVPQTCAVSSTVHSYVLAKLYEADMDLWAPPFDSLQTYMFEGDG 754

  Fly  1452 NSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYG--EEPS 1493
            :..||||||.|.|.|.:.:||:|:::||||||||::||  |.||
  Rat   755 SVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAELYGASEGPS 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	27/128 (21%)
		Cadherin_repeat	417..518	CDD:206637	36/107 (34%)
		Cadherin_repeat	531..619	CDD:206637	34/103 (33%)
		Cadherin_repeat	627..729	CDD:206637	28/104 (27%)
		Cadherin_repeat	736..834	CDD:206637	26/106 (25%)
		LamG	1127..1294	CDD:238058	9/166 (5%)
		Cadherin_C	1358..1489	CDD:279398	50/152 (33%)
Cdh20	NP_001012766.1	CA	85..163	CDD:214520	15/77 (19%)
		Cadherin_repeat	169..270	CDD:206637	36/109 (33%)
		Cadherin_repeat	278..385	CDD:206637	34/107 (32%)
		Cadherin_repeat	394..490	CDD:206637	28/104 (27%)
		Cadherin_repeat	498..595	CDD:206637	28/379 (7%)
		Cadherin_C	651..792	CDD:279398	50/152 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910