DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Cdh19

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_001009448.1	Gene:	Cdh19 / 360835	RGDID:	1307169	Length:	770	Species:	Rattus norvegicus

Alignment Length:	1140	Identity:	231/1140 - (20%)
Similarity:	371/1140 - (32%)	Gaps:	452/1140 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 IQVEDVNDNIPYYTEVKSGTILEN----EPPGTPVMQVRAFDMDGTSANNIVSFELADNRE-YFT 459
            :::|.....:|.....|.|.:.:.    |...| :..|.....|..:.||...::|....: .|:
  Rat    26 LKIEKAQRAVPSLGRAKRGWVWKQFVVPEEMDT-IQHVGRLRSDLDNGNNSFQYKLLGTGDGSFS 89

  Fly   460 IDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQ 524
            ||..||:|.|:...|||::..|.::....|.:      .|:.......|.|.:.|.||::|.|..
  Rat    90 IDEKTGDIFAMQKLDREKQSLYILRAQVIDTT------IGKAVEPESEFVIRVSDVNDNEPRFLD 148

  Fly   525 DKYLAERLL-EDANTNTEVIEVKAEDEDNA-----SQILYSIESGNVGDAFKIGLKTGKITVNQK 583
            :.|  |.:: |.:...|.||:|.|.|.|:.     ::|||::|.|.  ..|.:...||.|.::.|
  Rat   149 EPY--EAIVPEMSPEGTFVIKVTANDADDPTSGYHARILYNLEQGQ--PYFSVEPTTGVIRISSK 209

  Fly   584 LDYETITEYELKVRAFD-----GIYDDYTTVVIKIEDVNDNPPVFKQD-YSVTILEETTYDDCIL 642
            :|.|....|.:.::|.|     |.....||:.||:.|:|||.|:||:. |..||.|.......|.
  Rat   210 MDRELQDTYCVIIQAKDMLGQPGALSGTTTISIKLSDINDNKPIFKESFYRFTISESAPSGTTIG 274

  Fly   643 TVEAYDPDIKDRNADQHIVYSIHQNDGNRW--TIDN---SGCLRLVKTLDRDPPNGHKNWQVLIK 702
            .:.|||.||.: ||:..  |||..::...:  .|||   .|.:.|.|.:|.:..| |...:|.:|
  Rat   275 KIMAYDDDIGE-NAEMD--YSIEDDESQIFDIVIDNETQEGIVILKKKVDFEHQN-HYGIRVKVK 335

  Fly   703 ANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYDDTPGAGNF 767
            ....|                   .:.||..:|....|          :::|..|.|:.|
  Rat   336 NCHVD-------------------EELAPAHVNASTTY----------IKVQVEDEDEPP----- 366

  Fly   768 TFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISD--SGVPRQSAVSILHLVIGD 830
                                               .:.:|..|.:  .|.|..:.|..:..|..|
  Rat   367 -----------------------------------TFLLPYYIFEIPEGKPYGTMVGTVSAVDPD 396

  Fly   831 VNDNAM--SEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGM 893
            ...:.|  |...|::|..|..|....|::            |:.:...|
  Rat   397 RRQSPMRYSLIGSKMFDINGNGTIVTTNL------------LDREVSAW---------------- 433

  Fly   894 ITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISV 958
                       |:||...||.                                 .||.:
  Rat   434 -----------YNLSVTATET---------------------------------YNVQQ------ 448

  Fly   959 PRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIV 1023
                                       :|:..|:..:.|.|.             :|||     .
  Rat   449 ---------------------------ISSAHVYVQVLNIND-------------HAPE-----F 468

  Fly  1024 AQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQC 1088
            :|                     |.|.:.||.:.:.|:.::               ::|.
  Rat   469 SQ---------------------LYETYVCENAESGEIIQT---------------ISAI----- 492

  Fly  1089 VCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEI 1153
                                    |..:.....|       ||     |...:...||:  |..:
  Rat   493 ------------------------DRDESIEDHH-------FY-----FNHSVEDTNNS--SFIL 519

  Fly  1154 TPQIDQGLIMYLGPLNFNPLLAISDF--LALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQ 1216
            |...|...::......|: |...:.|  :.|..|||.|.||
  Rat   520 TDNQDNTAVILSNRAGFS-LKEETVFYMIILIADNGIPPLT------------------------ 559

  Fly  1217 LDIILQRTSIEMTVDNC----RLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTH 1277
                 ...::.:.|.:|    ...||
  Rat   560 -----STNTLTIQVCDCGDSRSTETC--------------------------------------- 580

  Fly  1278 VPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALL-- 1340
                                                 .|..:.|..|.....||||::|:.::
  Rat   581 -------------------------------------TSKELLFIMGFKAEAIIAIVICVMVIFG 608

  Fly  1341 LIILLAVVVQKKQKNGWHEKDIDDIRETIINYEDEGGGERDTD-YDLNVLRTQPFYEEK------ 1398
            .|.|:..:.|::::..:.|| .:|.||.|..|:||||||.|:: :|:..||......|:
  Rat   609 FIFLILALKQRRKETLFPEK-TEDFRENIFCYDDEGGGEEDSEAFDIIELRQSTVMRERKPRKSR 672

  Fly  1399 ------LYKDPHALQGNMRDPNDIPDIA---DFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSD 1454
                  ||:  .:||..       ||.|   .|:.:|.|..:.|..|...|.::.:||||.|:|.
  Rat   673 SAEIRSLYR--QSLQVG-------PDSAIFRKFILEKLEEANTDSSAPPFDSLQTFAYEGTGSSA 728

  Fly  1455 GSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYG 1489
            ||||||.|...|.:.:||||::.||.|::||:|:|
  Rat   729 GSLSSLGSSVTDQEDDFDYLNDLGPCFKRLANMFG 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	1/9 (11%)
		Cadherin_repeat	417..518	CDD:206637	25/105 (24%)
		Cadherin_repeat	531..619	CDD:206637	30/98 (31%)
		Cadherin_repeat	627..729	CDD:206637	27/106 (25%)
		Cadherin_repeat	736..834	CDD:206637	12/99 (12%)
		LamG	1127..1294	CDD:238058	22/172 (13%)
		Cadherin_C	1358..1489	CDD:279398	55/146 (38%)
Cdh19	NP_001009448.1	Cadherin_repeat	49..142	CDD:206637	24/99 (24%)
		Cadherin_repeat	150..250	CDD:206637	32/103 (31%)
		Cadherin_repeat	259..364	CDD:206637	33/137 (24%)
		Cadherin_repeat	373..464	CDD:206637	26/208 (13%)
		Cadherin_repeat	472..570	CDD:206637	26/185 (14%)
		Cadherin_C	617..764	CDD:395833	57/157 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910