DRSC/TRiP Functional Genomics Resources

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Protein Alignment shg and CadN

DIOPT Version :10

Sequence 1:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster
Sequence 2:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster


Alignment Length:2165 Identity:622/2165 - (28%)
Similarity:861/2165 - (39%) Gaps:777/2165 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 DNRKPAFKNCAGYAPKVKEEQPENTYVLTVEAVDPDP--DQVIRYSIVQSPFER-PKFFINPSTG 142
            ::.||.||:|:.|.|||:|..|..:.|:.|.|.|.|.  :..::|||||.|.:: .||.::..||
  Fly   962 NDNKPVFKDCSTYYPKVEEGAPNGSPVIKVVATDEDKGVNGQVKYSIVQQPNQKGTKFTVDEETG 1026

  Fly   143 VIFTTHTFDRDEPIHEKFVFVTVQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDESMSEN 207
            .:.|...||| |....|||.|||:|||.|.|.|:.||:|.|.|.|:|||.|.|::.:|.|::.::
  Fly  1027 EVSTNKVFDR-EGDDGKFVSVTVKATDQGDPSLEGVCSFTVEITDVNDNPPLFDRQKYVENVKQD 1090

  Fly   208 AQPDAVVMTISASDFDDGNNSLVEYEI---LRERDFQYFKIDKESGIIYLKRPIDK-RPGQSYAI 268
            |.....::.:||||.|..||..:.|.:   ....|.:||:|..|||.|.||:|:|. .|...|.:
  Fly  1091 ASIGTNILRVSASDEDADNNGAIVYSLTAPFNPNDLEYFEIQAESGWIVLKKPLDGCYPRDRYRL 1155

  Fly   269 IVRAYNVVPDPPQDAQIEVRIRVVESSIKPPSFVNPIDTPIYLKENLKNFTHPIATLRAVSNMPD 333
            .|.|.: ...|...|.::|.:.||:.:.|||.:...|..||:::||:...| .:.:::|.|.:..
  Fly  1156 RVSASD-KGTPASAADVDVELDVVDRNNKPPIWDKSIYGPIHIRENVTVGT-VVTSVKASSGIEG 1218

  Fly   334 KPEVIFELNTGRTEQTNSKNTFVFNQIGNE----VTISLGKTLDYEAITDYTLTMIVRN--THEL 392
            .|.|.:.|..|.|.|||..:||...|..:.    ..|.:...||||:|.:|.||:.|.|  ..:|
  Fly  1219 NPTVFYRLMPGSTAQTNKFHTFYLQQRPDNGDTWADIKVNHPLDYESIKEYNLTIRVENNGAQQL 1283

  Fly   393 GTEHQIKIQVEDVNDNIPYYTEVKSGTILENEPPGTPVMQVRAFDMDGTSANNIVSFELADN--- 454
            .:|..:.|.:|||||.||.:||.:..|:||.||.||.|.||.|.|.|||..||.|.:.:.|:   
  Fly  1284 ASEATVYIMLEDVNDEIPLFTEREQETVLEGEPIGTKVTQVNAIDKDGTFPNNQVYYYIVDSPRN 1348

  Fly   455 --REYFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKND 517
              :|:|.|:..:|.|...|.||||::..|.::|.|.|.:||:..::..||...:..||.|.||||
  Fly  1349 EGKEFFEINLQSGEIFTKTVFDREKKGAYALEVEARDGAPSARPNSNGPNSVTKFIRIGIADKND 1413

  Fly   518 HKPHFQQDKYLAERLLEDANTNTEVIEVKAEDEDNASQILYSIESGNVGDAFKIGLKTGKITVNQ 582
            :.|:|.:..|.|| :.|:.:....|:.|.|:|.|.:|:|.|.|.|||:|.||.:...||.|.|..
  Fly  1414 NPPYFDKSLYEAE-VDENEDIQHTVLTVTAKDHDESSRIRYEITSGNIGGAFAVKNMTGAIYVAG 1477

  Fly   583 KLDYETITEYELKVRAFDGIYDDYTTVVIKIEDVNDNPPVFKQ-DYSVTILEETTYDD-----CI 641
            .|||||...|||::.|.|.:.::||||:|.::|||||||||:: .|...|.||   ||     .:
  Fly  1478 ALDYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERPTYRTQITEE---DDRNLPKRV 1539

  Fly   642 LTVEAYDPDIKDRNADQHIVYSI------------HQNDGNRWTIDNSGCLRLVKTLDRDPPNGH 694
            |.|.|.|.| |||  .|:|||.:            .:.|.||.|    |.:.::|.||||.|||.
  Fly  1540 LQVTATDGD-KDR--PQNIVYFLTGQGIDPDNPANSKFDINRTT----GEIFVLKPLDRDQPNGR 1597

  Fly   695 KNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFL-------------------------- 733
            ..|:..:.|.||.|.|  :....:|.|.|||||||||..                          
  Fly  1598 PQWRFTVFAQDEGGEG--LVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVD 1660

  Fly   734 ----------------------------------------------------------------- 733
                                                                             
  Fly  1661 YDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMDGGG 1725

  Fly   734 -------------INEMPVY-----W--------------------------------------- 741
                         ||:||..     |                                       
  Fly  1726 LKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQYKVIDNS 1790

  Fly   742 ----------------------------------------------QENRN-------------- 746
                                                          ::|.|              
  Fly  1791 GYGADKFTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGEDNDNDKYHVAYSWVVVKL 1855

  Fly   747 ----------------------------------------------------------------- 746
                                                                             
  Fly  1856 RDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAINQNG 1920

  Fly   747 ---------------------------------------------------------------PG 748
                                                                           |.
  Fly  1921 SVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPR 1985

  Fly   749 HVVQLQANDYDDTPGAGN--FTFGIDSEATPDIKTKFSMDGDYLHAN----------VQFDREAQ 801
            .||::.|.|.||...:..  |.|.:|..|...|:..|.::.|...||          ..||||.|
  Fly  1986 KVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQ 2050

  Fly   802 KEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLD 866
            |||.|||.|.|.|.|..:..|.|.::|||||||.|..||..||:|||:|::|:|.||||:|.|||
  Fly  2051 KEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNYQGQSPDTPIGRVYVYDLD 2115

  Fly   867 DWDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHS---VDAYVT 928
            ||||.||.|.|:.:.|.:|:|:..:||:||...|.||.|.|.|.|     :..:|:   :.|.||
  Fly  2116 DWDLPDKKFYWEAMEHPRFKLDEDSGMVTMRAGTREGRYHLRFKV-----YDRKHTQTDIPANVT 2175

  Fly   929 VVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFT 993
            |.|||:|.|||..|||:|...::.|:||.|........:.|..||.:..||.|.||...|||:|:
  Fly  2176 VTVREIPHEAVVNSGSVRLSGISDEDFIRVWNYRTQSMSRSKMDRFRDKLADLLNTERENVDIFS 2240

  Fly   994 VLQNENH--TLDVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEES 1056
            |.....|  ..||||||||||||.|.:|||||..:::.:|.::.:.:.||.|||||.|...||.|
  Fly  2241 VQLKRKHPPLTDVRFSAHGSPYYKPVRLNGIVLMHREEIEKDVGINITMVGIDECLYENQMCEGS 2305

  Fly  1057 CTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRR--------CLNGG---SPRYGEND 1110
            |||.|..|.:|||:.:|.|:.|||.....|.|.|.|....:        |.|||   ..|:|.: 
  Fly  2306 CTNSLEISPLPYMVNANKTALVGVRVDTIADCTCGARNFTKPESCRTTPCHNGGRCVDTRFGPH- 2369

  Fly  1111 VCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPL---NFNP 1172
             |.|..|:|||.|:..:.:|.|:|:|:|.|:..|:.:.:|||...:...|||:|.||:   ..:.
  Fly  2370 -CSCPVGYTGPRCQQTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLIIYNGPIVPPERDE 2433

  Fly  1173 LLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVAD-RTYQLDIILQRTSIEMTVDNCRLS 1236
            .| ||||:||||:.|||.|.:|:|||.:.:|.:..|.:.| ..:::|:.....||.|.||.|:.:
  Fly  2434 TL-ISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWHRIDLFWDTESIRMVVDFCKSA 2497

  Fly  1237 ----------------TCQTLGAPIGP-NEFLNVNAPLQLGGTPVDLEQLGRQLN-WTHVPNQKG 1283
                            :||..| .|.| ||:||||||||:||  :..||..:.|. |.::|..||
  Fly  2498 EIAEMEDGTPPEFDDMSCQARG-QIPPFNEYLNVNAPLQVGG--LYREQFDQSLYFWHYMPTAKG 2559

  Fly  1284 FFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQS-------------------------------- 1316
            |.||||||..|.:.|:|..|.:.||..:||.|:                                
  Fly  2560 FDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQTEEVCAQTETTARCWEHGNCVGSLSEARCHCRP 2624

  Fly  1317 ---------------------VAVAFSFGIDR--------------------------------- 1327
                                 |..|.||..||                                 
  Fly  2625 GWTGPACNIPTIPTTFKAQSYVKYALSFEPDRFSTQVQLRFRTREEYGELFRVSDQHNREYGILE 2689

  Fly  1328 ------------------------NFII------------------------------------- 1331
                                    |.|:                                     
  Fly  2690 IKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQWHVVKVNRYGSAATLELDGGEGRRYNETFEFV 2754

  Fly  1332 ----------------------------------------------------------------- 1331
                                                                             
  Fly  2755 GHQWLLVDKQEGVYAGGKAEYTGVRTFEVYADYQKSCLDDIRLEGKHLPLPPAMNGTQWGQATMA 2819

  Fly  1332 ----------------------------------------------------------------- 1331
                                                                             
  Fly  2820 RNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTCGEGRIMSPDSKGCMDRNECLDMPCMNGATC 2884

  Fly  1332 ---------------------------------------AIIVCLALLLIILLAVVVQKKQKNGW 1357
                                                   ||:|||.::||::|..||..:::.. 
  Fly  2885 INLEPRLRYRCICPDGFWGENCELVQEGQTLKLSMGALAAILVCLLIILILVLVFVVYNRRREA- 2948

  Fly  1358 HEK---DIDDIRETIINYEDEGGGERD-TDYDLNVLRTQ---PFYEEKL-YKDPHALQGNMRDPN 1414
            |.|   ..||:||.||||:||||||.| |.:|:..|:..   |...|.. .|.|.........|.
  Fly  2949 HIKYPGPDDDVRENIINYDDEGGGEDDMTAFDITPLQIPIGGPMPPELAPMKMPIMYPVMTLMPG 3013

  Fly  1415 DIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGP 1479
            ..|::..|:.:.|:..|.|..|...||:|:|||||.|::.||||||||.|||....:|||..:||
  Fly  3014 QEPNVGMFIEEHKKRADGDPNAPPFDDLRNYAYEGGGSTAGSLSSLASGTDDEQQEYDYLGAWGP 3078

  Fly  1480 RFRKLADMYGEE---PSDTD 1496
            ||.|||:|||.|   |.:|:
  Fly  3079 RFDKLANMYGPEAPNPHNTE 3098

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637 45/100 (45%)
Cadherin_repeat 200..292 CDD:206637 30/95 (32%)
CA 332..410 CDD:214520 30/83 (36%)
Cadherin_repeat 417..518 CDD:206637 43/105 (41%)
Cadherin_repeat 531..619 CDD:206637 38/87 (44%)
Cadherin_repeat 627..729 CDD:206637 44/118 (37%)
Cadherin_repeat 736..834 CDD:206637 43/341 (13%)
LamG 1127..1294 CDD:238058 74/188 (39%)
CADH_Y-type_LIR 1430..1489 CDD:460041 34/58 (59%)
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
CA_like 449..541 CDD:481204
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637 0/1 (0%)
Cadherin_repeat 973..1074 CDD:206637 45/101 (45%)
Cadherin_repeat 1083..1166 CDD:206637 27/83 (33%)
Cadherin_repeat <1219..1298 CDD:206637 28/78 (36%)
Cadherin_repeat 1310..1414 CDD:206637 43/103 (42%)
Cadherin_repeat 1423..1514 CDD:206637 41/91 (45%)
Cadherin_repeat 1522..1630 CDD:206637 44/119 (37%)
Cadherin_repeat 1638..1741 CDD:206637 1/102 (1%)
CA 1770..1863 CDD:214520 2/92 (2%)
Cadherin_repeat 1871..1966 CDD:206637 0/94 (0%)
Cadherin_repeat 1974..2083 CDD:206637 38/108 (35%)
EGF 2350..2380 CDD:394967 11/31 (35%)
LamG 2385..2570 CDD:238058 74/188 (39%)
EGF_2 2605..2631 CDD:400365 0/25 (0%)
LamG 2637..2797 CDD:238058 8/159 (5%)
EGF_CA 2869..2907 CDD:238011 0/37 (0%)
CADH_Y-type_LIR 3029..3088 CDD:460041 34/58 (59%)
Blue background indicates that the domain is not in the aligned region.

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