DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and ft

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_477497.1	Gene:	ft / 33627	FlyBaseID:	FBgn0001075	Length:	5147	Species:	Drosophila melanogaster

Alignment Length:	1482	Identity:	366/1482 - (24%)
Similarity:	584/1482 - (39%)	Gaps:	319/1482 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AGHLNPAQQQTHQQHKRKCRDLGRRLIPARLLLGVIVAISLLSPALALHSP-----PDKNFSGDN 82
            ||||:..||..:                   :|.|:.:    ..|....:|     .|:|   ||
  Fly  2971 AGHLDREQQDEY-------------------ILKVVAS----DGAWRAETPITITIQDQN---DN 3009

  Fly    83 RKPAFKNCAGYAPKVKEEQPENTYVLTVEAVDPD---PDQVIRYSIVQSPFERPKFFINPSTGVI 144
             .|.|:: :.|:....|.|.....|..:.|.|.|   |:.||.||: |.|  .|.|.|:|:||.:
  Fly  3010 -APEFEH-SFYSFSFPELQQSIALVGQIIATDRDKQGPNSVISYSL-QQP--SPMFSIDPATGEV 3069

  Fly   145 FTTHT--FDRDEPIH--EKFVFVTVQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDESMS 205
            |:...  |...:.:.  |....:||.|||||.|||...|..|:.|.|.::|.|.|.:|.|...:.
  Fly  3070 FSKKAVRFKHSQYVRSPENMYALTVLATDNGKPPLYSECLVNINIVDAHNNPPKFEQAEYLAPLP 3134

  Fly   206 ENAQPDAVVMTISASDFDDGNNSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIV 270
            ::|.....::.:.|:|..|...:.::|.::.......|.:.:..|.|.|.:||...|...|.::|
  Fly  3135 QDAVRGQRIVRVHANDKQDLGTNEMDYSLMTFNLSSIFSVGRHDGWITLVKPIQVPPNTRYELVV 3199

  Fly   271 RAYNVVPD---PPQDAQIEVRIRVVESSIKPPSF-VNPIDTPIYLKENLKNFTHPI-ATLRAVSN 330
            ||    .|   |||..:..|.|.|...::..|.| ||...  :.:.||     .|: :|:
  Fly  3200 RA----TDRGVPPQSDETRVVIVVTGENMDTPRFSVNSYQ--VIVPEN-----EPVGSTI----- 3248

  Fly   331 MPDKPEVIFELNTGRTEQTNSKNTFVFNQI--GNEVT----------ISLGKTLDYEAITDYTLT 383
                      |..|.|:.....|..:...|  |||..          |.:.:.|||:.|.:|.|.
  Fly  3249 ----------LTVGATDDDTGPNGMLRYSISGGNERQDFSVDERTGGIVIQQQLDYDLIQEYHLN 3303

  Fly   384 MIVRNT--HELGTEHQIKIQVEDVNDNIPYYTEVKSGT-ILENEPPGTPVMQVRAFDMDGTSANN 445
            :.|::.  |.|.:...:.|.:.|||||.|.:...:... |.||:|.||.|.|..|.|.| :..|.
  Fly  3304 ITVQDLGYHPLSSVAMLTIILTDVNDNPPVFNHKEYHCYIPENKPVGTFVFQAHAADKD-SPKNA 3367

  Fly   446 IVSFEL---ADNREYFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQV 507
            |:.:..   ..:|.:|.::.:.|.|::..:||.|||..|.:::.|. |..||:       ..:..
  Fly  3368 IIHYAFLPSGPDRHFFIMNQSNGTISSAVSFDYEERRIYTLQIKAK-NPDSSM-------ESYAN 3424

  Fly   508 FRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDEDNA--SQILYSIESGNVGDAFK 570
            ..:.:...|:..|.|.|..:..: :.|.:...|.|..|:|.|:|:.  .::.|.:...:....|:
  Fly  3425 LYVHVLGVNEFYPQFLQPVFHFD-VSETSAVGTRVGAVQATDKDSGEDGRVYYLLVGSSNDKGFR 3488

  Fly   571 IGLKTGKITVNQKLDYETITEYELKVRA-----FDGIYDDYTTVVIKIEDVNDNPPVFKQDYSVT 630
            |...||.|.|.:.||.||.....|.|.|     ..|...|...|:|.|:|.||.|...|..|:.|
  Fly  3489 IDTNTGLIYVARHLDRETQNRVVLTVMAKNYGSIRGNDTDEAQVIISIQDGNDPPEFIKHYYTST 3553

  Fly   631 ILEETTYDDCILTVEAYDPDIKDRNADQHIVYS-IHQNDGNRWTID-NSGCLRLVKTLDRDPPNG 693
            |.|.......:.||:|.|.|::.:|  ....|| |:.|....:.|| .:|.:.....|||:..:
  Fly  3554 ISEAAPVGTKVTTVKAIDKDVRTQN--NQFSYSIINGNLKQSFKIDVQTGEISTASRLDREETS- 3615

  Fly   694 HKNWQVLIKAND-----EDGVGTTVSTVKEVTVTLKDINDNAP-FLINEMPVYWQENRNPG-HVV 751
              .:.::|.|.|     :.|..|       |.:.|:|:|||.| |....:..|..||...| .::
  Fly  3616 --TYNLVIGAIDTGLPPQTGSAT-------VHIELEDVNDNGPTFTPEGLNGYISENEPAGTSIM 3671

  Fly   752 QLQANDYDDTPGAGNFTFGIDSEATPDIKTKFSMD--GDYLHANVQFDREAQKEYFIPIRISDSG 814
            .|.|:|.|.....|.||:.:.....   |:..|:|  ...:.:...||||........|.:.|||
  Fly  3672 TLIASDPDLPRNGGPFTYQLIGGKH---KSWLSVDRNSGVVRSTTSFDREMTPILEAIIEVEDSG 3733

  Fly   815 VPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDL--DDWDLEDKYFEW 877
            .|:|.:..:|.:.:.|.|||..:..|..|.:..:.|:.|    ..|.:.|:  :|.|:...|
  Fly  3734 KPKQKSQHLLTITVLDQNDNPSTTRSLHIAVSLFNGDLP----SNVKLADVRPNDIDIVGDY--- 3791

  Fly   878 KDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFV-----PRH-SVDAYVTVVVRELPE 936
                ..:.:.||:...:.:.:..|......|......|:|.     .:| .|.:.|:|..:....
  Fly  3792 ----RCRLQKNPAQSQLQLAIPRACDLITTSHTTPIASVFSYTGNDGKHGDVSSKVSVAFQSFNN 3852

  Fly   937 EAVDKSGSIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVD---VFTVLQ-- 996
            |.:..|.||...|:|...|::   :...|....:|.|:            ||.|   ::::|:
  Fly  3853 ETLANSVSIMVRNMTAYHFLA---NHYRPILEMIKSRM------------SNEDEVILYSLLEGG 3902

  Fly   997 NENHT-----LDVRF--SAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCE 1054
            :.|.|     :.||.  :::..|.|..|:|     :.::...:||..:.::|..:.| .|...||
  Fly  3903 SGNSTNLQLLMAVRLAKTSYQQPKYLIERL-----REKRSAFSELLQKEVIVGYEPC-SEPDVCE 3961

  Fly  1055 E----SCTNEL---HKSSV---PYMIYSN-----------TTSFVG--------------VNAFV 1084
            .    |.|..|   |...:   |.::.|.           |:.|.|              .::.|
  Fly  3962 NGGVCSATMRLLDAHSFVIQDSPALVLSGPRVVHDYSCQCTSGFSGEQCSRRQDPCLPNPCHSQV 4026

  Fly  1085 QA-------QCVCEAP--------------LMRRCLNGGSPRY---GENDVCDCIDGFTGPHCEL 1125
            |.       ||:|.|.              ..:.|.||||.:.   |.:..|.|..||.|..||.
  Fly  4027 QCRRLGSDFQCMCPANRDGKHCEKERSDVCYSKPCRNGGSCQRSPDGSSYFCLCRPGFRGNQCES 4091

  Fly  1126 VS------VAFYGSGYAFYEPIAACNNT----------------KISLEITPQID---QGLIMYL 1165
            ||      ...:|......:|...||.|                .:|....|.:|   ..:.:..
  Fly  4092 VSDSCRPNPCLHGGLCVSLKPGYKCNCTPGRYGRHCERFSYGFQPLSYMTFPALDVTTNDISIVF 4156

  Fly  1166 GPLNFNPLLAI---------SDFLALELDNGYPVLTVDYGSGAIRIRHQHI------------KM 1209
            .....|.||..         |||||:||.:|    ...:.||..|.....:            |:
  Fly  4157 ATTKPNSLLLYNYGMQSGGRSDFLAIELVHG----RAYFSSGGARTAISTVIAGRNLADGGWHKV 4217

  Fly  1210 VADRTYQLDIILQRTSIEMTVDN------CRLSTCQTLGAPIGPNEFLNVN-APLQLGG----TP 1263
            .|.|..:    :...|:....|:      |...........:||...||.| .||.:||    .|
  Fly  4218 TATRNGR----VMSLSVAKCADSGDVCTECLPGDSSCYADEVGPVGTLNFNKQPLMIGGLSSADP 4278

  Fly  1264 VDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQ 1315
            : ||:.|:       .:.....||:.::.|..:..||.:|...:.|.:||.:
  Fly  4279 I-LERPGQ-------VHSDDLVGCLHSVHIGGRALNLSLPLQQKGILAGCNR 4322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637	37/104 (36%)
		Cadherin_repeat	200..292	CDD:206637	23/94 (24%)
		CA	332..410	CDD:214520	24/91 (26%)
		Cadherin_repeat	417..518	CDD:206637	28/104 (27%)
		Cadherin_repeat	531..619	CDD:206637	28/94 (30%)
		Cadherin_repeat	627..729	CDD:206637	29/108 (27%)
		Cadherin_repeat	736..834	CDD:206637	27/100 (27%)
		LamG	1127..1294	CDD:238058	44/223 (20%)
		Cadherin_C	1358..1489	CDD:279398
ft	NP_477497.1	Cadherin_repeat	71..152	CDD:206637
		Cadherin_repeat	163..266	CDD:206637
		Cadherin_repeat	275..378	CDD:206637
		Cadherin_repeat	393..490	CDD:206637
		Cadherin_repeat	498..594	CDD:206637
		Cadherin_repeat	603..704	CDD:206637
		Cadherin_repeat	735..814	CDD:206637
		Cadherin	843..>907	CDD:278457
		Cadherin	950..1026	CDD:278457
		Cadherin_repeat	1053..1149	CDD:206637
		Cadherin_repeat	1157..1274	CDD:206637
		Cadherin_repeat	1282..1380	CDD:206637
		Cadherin_repeat	1390..1485	CDD:206637
		Cadherin_repeat	1497..1597	CDD:206637
		Cadherin_repeat	1621..1699	CDD:206637
		Cadherin_repeat	1720..1818	CDD:206637
		Cadherin_repeat	1827..1918	CDD:206637
		Cadherin_repeat	1926..2023	CDD:206637
		Cadherin_repeat	2031..2162	CDD:206637
		Cadherin_repeat	2172..2274	CDD:206637
		Cadherin_repeat	2282..2380	CDD:206637
		Cadherin_repeat	2388..2487	CDD:206637
		Cadherin_repeat	2495..2592	CDD:206637
		Cadherin_repeat	2600..2694	CDD:206637
		Cadherin_repeat	2710..2806	CDD:206637
		Cadherin_repeat	2814..2909	CDD:206637
		Cadherin_repeat	2917..3009	CDD:206637	12/63 (19%)
		Cadherin	3018..3114	CDD:278457	35/98 (36%)
		Cadherin	3129..3220	CDD:278457	23/94 (24%)
		Cadherin_repeat	3233..3330	CDD:206637	26/118 (22%)
		Cadherin_repeat	3338..3434	CDD:206637	27/104 (26%)
		Cadherin_repeat	3443..3541	CDD:206637	27/98 (28%)
		Cadherin_repeat	3550..3647	CDD:206637	29/108 (27%)
		Cadherin_repeat	3657..3753	CDD:206637	27/98 (28%)
		EGF	4017..4047	CDD:278437	6/29 (21%)
		EGF_CA	4056..4090	CDD:238011	11/33 (33%)
		EGF_CA	4094..4128	CDD:238011	5/33 (15%)
		Laminin_G_1	4156..4306	CDD:278483	36/165 (22%)
		LamG	4428..4543	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24026
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010