DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Cdh18

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_001101126.2	Gene:	Cdh18 / 310174	RGDID:	1305430	Length:	790	Species:	Rattus norvegicus

Alignment Length:	1182	Identity:	232/1182 - (19%)
Similarity:	344/1182 - (29%)	Gaps:	565/1182 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 KTLDYEAITDYTL--TMIVRNTHE-LGTEHQIKIQVEDVNDNIPYYTEVKSG----TILENEPPG 427
            |:||.|..|.|.|  ..|.|.|:: |..|.:..|:|:|:|||.|.:|:   |    |:.|....|
  Rat   114 KSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTD---GPYIVTVPEMSDMG 175

  Fly   428 TPVMQVRAFDMD----GTSANNIVSFELADNREYFTIDPNTGNI-TALTTFDREERDFYNVKVIA 487
            |.|:||.|.|.|    |.||.  |.:.:...:.||::||.||.| |||...|||.|:.|:|.:.|
  Rat   176 TSVLQVTATDADDPTYGNSAR--VVYSILQGQPYFSVDPKTGVIRTALHNMDREAREHYSVVIQA 238

  Fly   488 SDNSPSSLFDNGEPN--RGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDE 550
            .|.:       |:..  .|.....|::.|.||:.|.|.| |:....:.|.|...:.|.::||.|.
  Rat   239 KDMA-------GQVGGLSGSTTVNITLTDVNDNPPRFPQ-KHYQLYVPESAQVGSAVGKIKANDA 295

  Fly   551 DNAS--QILYSIESGNVGDAFKIG----LKTGKITVNQKLDYETITEYELKVRAFD--------- 600
            |..|  .:.|||.:|:....|.|.    .:.|.:::.:.|:||....|.|.:...:
  Rat   296 DTGSNADMTYSITNGDGIGVFSISTDKDTREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSH 360

  Fly   601 -GIYDDYTTVVIKIEDVNDNPPVFKQ-DYSVTILEETTYDDCILTVEAYDPDIKDRNADQHIVYS 663
             |.:.|.|.:.|.:.|| |.||:|.. .|.:.:.|.......:.||.|.|||    :|:..:.|.
  Rat   361 LGPFKDATMLKIIVGDV-DEPPLFSMPSYVMEVYENAKIGTIVGTVLAQDPD----SANSLVRYF 420

  Fly   664 I-HQNDGNR-WTID-NSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVSTVKEVTVTLKD 725
            | |..:..| :.|| |:|.::..|.|||:....: |..|....||...:.:.||    |.:.:.|
  Rat   421 INHSTEEERFFNIDANTGTIKTSKVLDREETPWY-NITVTASENDNPDLLSHVS----VGIRVLD 480

  Fly   726 INDNAPFLINEMPVYWQENRNPGHVVQ-LQANDYDDTPGAGNFTFGIDSE--ATPDIKTKFSMD- 786
            :|||.|.|..|..:...||..||.|:. :.|.|.||......|.|.:|..  ..|:...|.:.|
  Rat   481 VNDNPPELAREYDIVVCENSKPGQVIHTITATDKDDFANGPRFNFFLDERLPMNPNFTLKDNEDN 545

  Fly   787 -GDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKG 850
             ...|....:|.|..|..|::||.|||.|:|..|:.|
  Rat   546 TASILTRRRRFSRTMQDVYYLPIMISDGGIPSLSSSS---------------------------- 582

  Fly   851 EAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDS 915

  Rat   583 ----------------------------------------------------------------- 582

  Fly   916 MFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSLAK 980

  Rat   583 ----------------------------------------------------------------- 582

  Fly   981 LFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDE 1045
                                ||.:|.
  Rat   583 --------------------TLTIRV--------------------------------------- 588

  Fly  1046 CLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPRYGEND 1110
                                                      |.||.
  Rat   589 ------------------------------------------CACER------------------ 593

  Fly  1111 VCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLA 1175
                 ||
  Rat   594 -----DG---------------------------------------------------------- 595

  Fly  1176 ISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQT 1240
                                                                      |:.||.
  Rat   596 ----------------------------------------------------------RVRTCH- 601

  Fly  1241 LGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSV 1305

  Rat   602 ----------------------------------------------------------------- 601

  Fly  1306 FRNIDSGCQQSVAVAF--SFGIDRNFIIAIIVCLALLLIILLAVVVQKKQKNGWHEKDIDDIRET 1368
                        |.||  |.|:....:|||::|:.:||.|::..:..::.|........:|:||.
  Rat   602 ------------AEAFLSSAGLSTGALIAILLCVVILLAIVVLFITLRRSKKEPLIISEEDVREN 654

  Fly  1369 IINYEDEGGGERDTD-YDLNVLRTQPFYEEKLYKDPHALQGNMRD--------PN-------DIP 1417
            ::.|:||||||.||: :|:..||.....||..|:         ||        |.       :..
  Rat   655 VVTYDDEGGGEEDTEAFDITALRNPSAAEEFKYR---------RDIRPEVKLTPRHQTLSTLESI 710

  Fly  1418 DIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFR 1482
            |:.:|:..:....|.|......|.::.|||||..:..||:|||.|.|...|.::.||.::||.|:
  Rat   711 DVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEFK 775

  Fly  1483 KLADMYGEEPSD 1494
            |||::|||..|:
  Rat   776 KLAELYGEIESE 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	18/42 (43%)
		Cadherin_repeat	417..518	CDD:206637	38/111 (34%)
		Cadherin_repeat	531..619	CDD:206637	26/103 (25%)
		Cadherin_repeat	627..729	CDD:206637	30/104 (29%)
		Cadherin_repeat	736..834	CDD:206637	30/102 (29%)
		LamG	1127..1294	CDD:238058	3/166 (2%)
		Cadherin_C	1358..1489	CDD:279398	47/146 (32%)
Cdh18	NP_001101126.2	CA	79..157	CDD:214520	18/42 (43%)
		Cadherin_repeat	163..264	CDD:206637	37/109 (34%)
		Cadherin_repeat	272..379	CDD:206637	26/107 (24%)
		Cadherin_repeat	387..484	CDD:206637	30/105 (29%)
		Cadherin_repeat	491..589	CDD:206637	33/356 (9%)
		Cadherin_C	637..783	CDD:395833	49/154 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910