Protein Alignment shg and Cdh12

DIOPT Version :9

• Sequence 1: NP_476722.1
• Gene: shg / 37386
• FlyBaseID: FBgn0003391
• Length: 1507
• Species: Drosophila melanogaster
• Sequence 2: XP_017446901.1
• Gene: Cdh12 / 301887
• RGDID: 1566350
• Length: 794
• Species: Rattus norvegicus
• Alignment Length: 1153
• Identity: 249/1153 - (21%)
• Similarity: 385/1153 - (33%)
• Gaps: 456/1153 - (39%)

  Fly   407 DNI-------PYYTEVKSG------TILENEPPGTPVMQVRAFDMDGTSANNIVSFELADN--RE 456
            ||:       .::..||.|      .:|| |..|:....|.....|.......|.:.|:.:  ..
  Rat    37 DNVIHLLGRRSHFQRVKRGWVWNQFFVLE-EYMGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGT 100

  Fly   457 YFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPH 521
            .||||..||:|.|:.:.||||:.||.::..|.|      .:..:|......|.|.:.|.||::|.
  Rat   101 VFTIDETTGDIHAIRSLDREEKPFYTLRAQAVD------IETRKPLEPESEFIIKVQDINDNEPK 159

  Fly   522 FQQDKYLAERLLEDANTNTEVIEVKAEDED-----NASQILYSIESGNVGDAFKIGLKTGKI-TV 580
            |....|:|. :.|.:.....|::|||.|.|     |:::::|||..|.  ..|.|..|||.| |.
  Rat   160 FLDGPYVAS-VPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQ--PYFSIDPKTGVIRTA 221

  Fly   581 NQKLDYETITEYELKVRAFD-----GIYDDYTTVVIKIEDVNDNPPVF-KQDYSVTILEETTYDD 639
            ...:|.|...:|::.::|.|     |.....|.|.|.:.|||||||.| |..:.:.:.|.:....
  Rat   222 LPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPVGS 286

  Fly   640 CILTVEAYDPDIKDRNADQHIVYSIHQND-GNRWTI-----DNSGCLRLVKTLDRDPPNGHKNWQ 698
            .|..:.|.|||. .:||:  |.|:|...| ||.:.|     ...|.::|.|.||.:.   .|.:.
  Rat   287 AIGRIRAVDPDF-GKNAE--IEYNIVPGDGGNLFDIVTDEDTQEGIIKLKKPLDFET---KKAYT 345

  Fly   699 VLIKAND--------EDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQA 755
            ..::|::        ..|.....:|||   :::.|:::...|   ..|:|..|
  Rat   346 FKVEASNLHLDHRFHSAGPFKDTATVK---ISVLDVDEPPVF---SKPLYTME------------ 392

  Fly   756 NDYDDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSA 820
             .|:|||
  Rat   393 -VYEDTP---------------------------------------------------------- 398

  Fly   821 VSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQF 885
               :..:||.|....:..|||.:               |.|:|             ||......|
  Rat   399 ---VGTIIGAVTAQDLDVGSSAV---------------RYFID-------------WKSDGDSYF 432

  Fly   886 RLNPSTGMIT---MLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVV-VRELPEEAVDKSGSIR 946
            .::.:.|.|.   :|......:|:.|.:.::.|.......|:..:.|: |.|.|.|
  Rat   433 TIDGTEGTIATNELLDRENTAQYNFSIIASKVSNPSLTSKVNILINVLDVNEFPPE--------- 488

  Fly   947 FINVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSV-SNVDVFTVLQNENHTLDVRFSAHG 1010
                     ||||                      :.|:| .|.....::|... .:|...|..|
  Rat   489 ---------ISVP----------------------YETAVCENAKPGQIIQIVG-AVDRDLSPAG 521

  Fly  1011 SPY---YAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYS 1072
            ..:   .|||   .::..|                                         :.::.
  Rat   522 QQFSFRLAPE---AVIKPN-----------------------------------------FTVHD 542

  Fly  1073 NTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAF 1137
            ...:..|:..             ||  ||.|.|..|
  Rat   543 FRNNTAGIET-------------RR--NGYSRRQQE----------------------------- 563

  Fly  1138 YEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRI 1202
                                          |.|.|::       :| |:.|||
  Rat   564 ------------------------------LYFLPIV-------IE-DSSYPV------------ 578

  Fly  1203 RHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLE 1267
                               |.::..||:..||   |.:.|.
  Rat   579 -------------------QSSTNTMTIRVCR---CDSDGT------------------------ 597

  Fly  1268 QLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIA 1332
                            ...|                    |::       |:....|:....:||
  Rat   598 ----------------ILSC--------------------NVE-------AIFLPVGLSTGALIA 619

  Fly  1333 IIVCLALLLIILLAVVVQKKQKNGWHEKDI-----DDIRETIINYEDEGGGERDTD-YDLNVLRT 1391
            |::|:.:||.|::..|..::||    :||.     :|||:.:|:|:||||||.||. :|:..||.
  Rat   620 ILLCIVILLAIVVLYVALRRQK----KKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRN 680

  Fly  1392 QPFYEEK-----LYKDPHALQGNMRDPNDIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDG 1451
            ....||.     :..|...|........|..||.||:..:.:..|.|..|...|.:..|||||:|
  Rat   681 PKVIEENKIRRDIKPDSFCLPRQRPQVEDNTDIRDFIHQRLQENDADPAAPPYDSLATYAYEGNG 745

  Fly  1452 NSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYGEEPSDTDSNV 1499
            :...||||:.|.|.:.|.::||||::||||:.||||:|||.|....||
  Rat   746 SVAESLSSIDSLTSEADQDYDYLSDWGPRFKVLADMFGEEESYNPDNV 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	2/9 (22%)
		Cadherin_repeat	417..518	CDD:206637	30/108 (28%)
		Cadherin_repeat	531..619	CDD:206637	31/98 (32%)
		Cadherin_repeat	627..729	CDD:206637	27/115 (23%)
		Cadherin_repeat	736..834	CDD:206637	10/97 (10%)
		LamG	1127..1294	CDD:238058	16/166 (10%)
		Cadherin_C	1358..1489	CDD:279398	56/141 (40%)
Cdh12	XP_017446901.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910