DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Cdh10

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_001162102.1	Gene:	Cdh10 / 29181	RGDID:	619741	Length:	788	Species:	Rattus norvegicus

Alignment Length:	1183	Identity:	246/1183 - (20%)
Similarity:	361/1183 - (30%)	Gaps:	564/1183 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 KTLDYEAITDYTLTMIVRNTHEL---GTEHQIKIQVEDVNDNIPYY-TEVKSGTILENEPPGTPV 430
            :.:|.|....|||.....|...|   ..|.:..|::.|:|||.|.: .|:.:.::.|....||.|
  Rat   115 RRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSV 179

  Fly   431 MQVRAFDMDGTSANNI--VSFELADNREYFTIDPNTGNI-TALTTFDREERDFYNVKVIASDNSP 492
            :||.|.|.|..|..|.  |.:.:...:.||:::|.||.| |||...:||.::.|.|.:.|.|.
  Rat   180 VQVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRTALPNMNRENKEQYQVVIQAKDM-- 242

  Fly   493 SSLFDNGEPN--RGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDEDNA-- 553
                 .|:..  .|.....|::.|.||:.|.|.|:. :..|:||.:...|.|..|||.|.|..
  Rat   243 -----GGQMGGLSGTTTVNITLTDVNDNPPRFPQNT-IHLRVLESSPVGTAVGSVKATDADTGKN 301

  Fly   554 SQILYSIESGNVGDAFKI----GLKTGKITVNQKLDYETITEYELKVRA----------FDGIYD 604
            :::.|.|..|:..|.|.|    ..:.|.|||.:.||||....|.|||.|          :.|.:.
  Rat   302 AEVDYRIIDGDGTDMFDIITEKDTQEGIITVKKPLDYENRRLYTLKVEAENTHVDPRFYYLGPFK 366

  Fly   605 DYTTVVIKIEDVNDNPPVF-KQDYSVTILEETTYDDCILTVEAYDPD--------IKDRNADQHI 660
            |.|.|.|.|||| |.|||| :..|...:.|:......|.||.|.|||        ..||:.|...
  Rat   367 DTTIVKISIEDV-DEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSTSSPIRFTLDRHTDLDR 430

  Fly   661 VYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVSTVKEVT----- 720
            :::||..:|:.:|         .|.|||:....| |..|         :...::..||.|
  Rat   431 IFNIHSGNGSLYT---------SKPLDRELSQWH-NLTV---------IAAEINNPKETTRVSVF 476

  Fly   721 VTLKDINDNAPFLINEMPVYWQ----ENRNPGHVVQ-LQANDYDDTPGAGNFTFGIDSEATPDIK 780
            |.:.|:|||||    :..|::.    ||..||.::| :.|.|.||..|...|.|.:.:
  Rat   477 VRILDVNDNAP----QFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSLAA------- 530

  Fly   781 TKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFI 845

  Rat   531 ----------------------------------------------------------------- 530

  Fly   846 YNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFV 910
                                                     :||:
  Rat   531 -----------------------------------------VNPN-------------------- 534

  Fly   911 VTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPDALSLKDRLQ 975

  Rat   535 ----------------------------------------------------------------- 534

  Fly   976 LSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLM 1040
                            |||..||::|..:
  Rat   535 ----------------FTVQDNEDNTARI------------------------------------ 547

  Fly  1041 VNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPR 1105
                                                                 |.|:
  Rat   548 -----------------------------------------------------LTRK-------- 551

  Fly  1106 YGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNF 1170
                      :||                          |..:||..:.|
  Rat   552 ----------NGF--------------------------NRHEISTYLLP--------------- 565

  Fly  1171 NPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRL 1235
               :.||       ||.||:                               |.::..:|:   |:
  Rat   566 ---VVIS-------DNDYPI-------------------------------QSSTGTLTI---RV 586

  Fly  1236 STCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNL 1300
            ..|.:.|
  Rat   587 CACDSQG---------------------------------------------------------- 593

  Fly  1301 GMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQKNGWHEKD---- 1361
                   |:.| | .:.|:....|:....:|||::|:.:||:|::.....|:|:    :|:
  Rat   594 -------NMQS-C-SAEALLLPAGLSTGALIAILLCIIILLVIVVLFAALKRQR----KKEPLIL 645

  Fly  1362 -IDDIRETIINYEDEGGGERDTD-YDLNVLRTQPFYEE-KLYKD--PHALQGNMRDPN--DIPDI 1419
             .:|||:.|::|.||||||.||. :|:..||.....|| ||.:|  |..|....|.|.  |..|:
  Rat   646 SKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIEEKKLRRDIIPETLFIPRRTPTAPDNTDV 710

  Fly  1420 ADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKL 1484
            .||:.::.:..|.|..|...|.:..|||||:.:...|||||.|.|.:||.|:|||..:||||.||
  Rat   711 RDFINERLKEHDLDPTAPPYDSLATYAYEGNDSVAESLSSLESGTTEGDQNYDYLREWGPRFNKL 775

  Fly  1485 ADMYGEEPSDTDS 1497
            |:|||...||.|:
  Rat   776 AEMYGGGESDKDA 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	13/42 (31%)
		Cadherin_repeat	417..518	CDD:206637	32/105 (30%)
		Cadherin_repeat	531..619	CDD:206637	38/103 (37%)
		Cadherin_repeat	627..729	CDD:206637	29/114 (25%)
		Cadherin_repeat	736..834	CDD:206637	13/102 (13%)
		LamG	1127..1294	CDD:238058	15/166 (9%)
		Cadherin_C	1358..1489	CDD:279398	60/141 (43%)
Cdh10	NP_001162102.1	CA	80..158	CDD:214520	13/42 (31%)
		Cadherin_repeat	164..265	CDD:206637	32/107 (30%)
		Cadherin_repeat	273..380	CDD:206637	38/108 (35%)
		Cadherin_repeat	388..485	CDD:206637	29/115 (25%)
		Cadherin_repeat	493..587	CDD:206637	37/499 (7%)
		Cadherin_C	643..780	CDD:279398	59/136 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910