DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Cdh9

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_001162101.1	Gene:	Cdh9 / 29163	RGDID:	1308343	Length:	788	Species:	Rattus norvegicus

Alignment Length:	1204	Identity:	244/1204 - (20%)
Similarity:	373/1204 - (30%)	Gaps:	573/1204 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 NTFVFNQIGNEVTISLGKTLDYEAITDYTL--TMIVRNT-HELGTEHQIKIQVEDVNDNIPYYT- 413
            |.||.::  |...|...|.||.|..:.|.|  ..|.|.| .::..|.:..|::.|:|||.|.:|
  Rat    98 NLFVIDE--NTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTK 160

  Fly   414 EVKSGTILENEPPGTPVMQVRAFDMD----GTSANNIVSFELADNREYFTIDPNTGNI-TALTTF 473
            ::.:.::.|....||.|:||.|.|.|    |.||.  |.:.:...:.||::||.:|.| |||...
  Rat   161 DLYTASVPEMSGVGTSVIQVTATDADDANYGNSAK--VVYSILQGQPYFSVDPESGIIKTALPDM 223

  Fly   474 DREERDFYNVKVIASDNSPSSLFDNGEPN--RGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDA 536
            .||.|:.|.|.:.|.|.       .|:..  .|.....|::.|.|::.|.|.|..|.... ||.|
  Rat   224 SRENREQYQVVIQAKDM-------GGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNS-LESA 280

  Fly   537 NTNTEVIEVKAEDEDNA--SQILYSIESGNVGDAFKI----GLKTGKITVNQKLDYETITEYELK 595
            ...|.:..:||.|.|..  :::.|||..|...|.|.:    ..:.|.|||.|.||:|....|.|:
  Rat   281 PLGTHLGRIKANDPDTGENAELEYSISEGEGSDMFDVITDKDTQEGIITVKQNLDFEKKMLYTLR 345

  Fly   596 VRAFD----------GIYDDYTTVVIKIEDVNDNPPVF-KQDYSVTILEETTYDDCILTVEAYDP 649
            |.|.:          |.:.|...|.|.:||| |.|||| |..|.:.:.|:......|..|.||||
  Rat   346 VDASNTHPDPRFLHLGPFKDSAMVKISVEDV-DEPPVFSKLSYLMEVDEDVKEGSIIGQVTAYDP 409

  Fly   650 D-----IK---DRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVLIKANDE 706
            |     ||   ||:.|...|:|||..:|:.:|:         |.|||:....|   .:.:.|
  Rat   410 DAMNNIIKYSVDRHTDMDRVFSIHSENGSIFTL---------KPLDRESSPWH---NITVTA--- 459

  Fly   707 DGVGTTVSTVKE-----VTVTLKDINDNAPFLINEMPVYWQ----ENRNPGHVVQ-LQANDYDDT 761
                |.::..|:     |.:.:.||||:||    |..:|::    ||...|.::| :...|.||.
  Rat   460 ----TEINNPKQSSQIAVFIRILDINDHAP----EFAMYYETFVCENAKSGQLIQTISVMDKDDP 516

  Fly   762 PGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHL 826
            |....|
  Rat   517 PRGHKF----------------------------------------------------------- 522

  Fly   827 VIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPST 891
                                                           :||    |..:|.|||:
  Rat   523 -----------------------------------------------FFE----PVPEFPLNPN- 535

  Fly   892 GMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFI 956

  Rat   536 ----------------------------------------------------------------- 535

  Fly   957 SVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNG 1021
                                               ||::.|:::|.                  |
  Rat   536 -----------------------------------FTIVDNKDNTA------------------G 547

  Fly  1022 IVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQA 1086
            |:.:......|:::..:|                           |.:|:
  Rat   548 IITRKDGYSRNKMNTYLL---------------------------PVLIF--------------- 570

  Fly  1087 QCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISL 1151

  Rat   571 ----------------------------------------------------------------- 570

  Fly  1152 EITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQ 1216
                                             ||.||:
  Rat   571 ---------------------------------DNDYPI-------------------------- 576

  Fly  1217 LDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQ 1281
                 |.::..:|:   |:..|...|
  Rat   577 -----QSSTGTLTI---RVCACDNQG--------------------------------------- 594

  Fly  1282 KGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLA 1346
                        |.|:.|                :.|:..:.|:....:|||::|:.:||.:::.
  Rat   595 ------------NMQSCN----------------AEALMLAAGLSTGALIAILLCVVILLTLIVL 631

  Fly  1347 VVVQKKQKNGWHEKD-----IDDIRETIINYEDEGGGERDTD-YDLNVLRTQPFYEE-KLYKD-- 1402
            ....|:|:    :|:     .||:|:.|:.|.||||||.||. :|:..||.....|: ||.:|
  Rat   632 FAALKRQR----KKEPLIISKDDVRDNIVTYNDEGGGEEDTQAFDIGTLRNPEAREDSKLRRDVM 692

  Fly  1403 PHALQGNMRDPNDIP-----DIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLAS 1462
            |..:   .:....:|     |:.||:..:.:..|.|..|...|.:..|||||:.:...|||||.|
  Rat   693 PETI---FQIRRTVPLWENIDVQDFIHRRLKENDSDPSAPPYDSLATYAYEGNDSVANSLSSLES 754

  Fly  1463 CTDDGDLNFDYLSNFGPRFRKLADMYGEEPSDTD 1496
            .|.|.:.::||||::||||:|||:|||.:.||.|
  Rat   755 LTADCNQDYDYLSDWGPRFKKLAEMYGGDDSDRD 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	20/59 (34%)
		Cadherin_repeat	417..518	CDD:206637	34/107 (32%)
		Cadherin_repeat	531..619	CDD:206637	33/103 (32%)
		Cadherin_repeat	627..729	CDD:206637	32/114 (28%)
		Cadherin_repeat	736..834	CDD:206637	11/102 (11%)
		LamG	1127..1294	CDD:238058	9/166 (5%)
		Cadherin_C	1358..1489	CDD:279398	55/144 (38%)
Cdh9	NP_001162101.1	Cadherin_repeat	71..154	CDD:206637	18/57 (32%)
		Cadherin_repeat	163..263	CDD:206637	34/108 (31%)
		Cadherin_repeat	271..378	CDD:206637	34/108 (31%)
		Cadherin_repeat	386..483	CDD:206637	32/115 (28%)
		Cadherin_repeat	491..588	CDD:206637	33/499 (7%)
		Cadherin_C	644..781	CDD:279398	54/139 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910