DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Cdh6

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_037059.2	Gene:	Cdh6 / 25409	RGDID:	2322	Length:	790	Species:	Rattus norvegicus

Alignment Length:	1291	Identity:	276/1291 - (21%)
Similarity:	403/1291 - (31%)	Gaps:	610/1291 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 PSFVNPIDTPIYLKENLKNFTHPIATLRAVSNMPDKPEVIFELNTGRTEQTNSKNTFVFNQ---- 359
            |:|.||:.                   :..|..|.|...:......|.|.:.||.::::||
  Rat    18 PTFSNPLS-------------------KRTSGFPAKRRALELSANSRNELSRSKRSWMWNQFFLL 63

  Fly   360 --------------------------------------IGNEVT--ISLGKTLDYEAITDYTL-- 382
                                                  |.||.|  |...|.||.|....|.|
  Rat    64 EEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRA 128

  Fly   383 TMIVRNT-HELGTEHQIKIQVEDVNDNIPYYT-EVKSGTILENEPPGTPVMQVRAFDMD----GT 441
            ..|.|.| ..:..|.:..|::.|:|||.|.:| :|.:.|:.|....||.|:||.|.|.|    |.
  Rat   129 QAINRRTGRPVEPESEFIIKIHDINDNEPIFTKDVYTATVPEMADVGTFVVQVTATDADDPTYGN 193

  Fly   442 SANNIVSFELADNREYFTIDPNTGNI-TALTTFDREERDFYNVKVIASDNSPSSLFDNGEPN--R 503
            ||.  |.:.:...:.||:::..||.| |||...|||.|:.|.|.:.|.|.       .|:..  .
  Rat   194 SAK--VVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDM-------GGQMGGLS 249

  Fly   504 GHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDED---NASQILYSIESGNV 565
            |.....|::.|.||:.|.|.|..| ..:..|.:...|.:..:||.|.|   || :|.|||..|..
  Rat   250 GTTTVNITLTDVNDNPPRFPQSTY-QFKTPESSPPGTPIGRIKASDADVGENA-EIEYSITDGEG 312

  Fly   566 GDAFKI----GLKTGKITVNQKLDYETITEYELKVRA----------FDGIYDDYTTVVIKIEDV 616
            .|.|.:    ..:.|.|||.:.||:|....|.|||.|          :.|.:.|..||.|.::||
  Rat   313 HDMFDVITDQETQEGIITVKKLLDFEKKRVYTLKVEASNPHIEPRFLYLGPFKDSATVRIVVDDV 377

  Fly   617 NDNPPVF-KQDYSVTILEETTYDDCILTVEAYDPD-----IK---DRNADQHIVYSIHQNDGNRW 672
             |.|||| |..|.:.|.|:...:..|.:|.|.|||     :|   ||:.|...:::|...:|:.:
  Rat   378 -DEPPVFSKLAYILQIREDAQINTTIGSVAAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIF 441

  Fly   673 TIDNSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEM 737
            |         .|.|||:....|                       .:||...:||:
  Rat   442 T---------SKLLDRETLLWH-----------------------NITVIATEINN--------- 465

  Fly   738 PVYWQENRNPGHVVQLQANDYDDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQK 802

  Rat   466 ----------------------------------------------------------------- 465

  Fly   803 EYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDD 867
                         |:||:...|::.:.|||||                 |||      |.:
  Rat   466 -------------PKQSSRVPLYIKVLDVNDN-----------------APE------FAE---- 490

  Fly   868 WDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVR 932
                  ::|                  |.:...|:.          |.:....|:||       :
  Rat   491 ------FYE------------------TFVCEKAKA----------DQLIQTLHAVD-------K 514

  Fly   933 ELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQN 997
            :.|......|.|:                  :|:|                .|.||   ||:..|
  Rat   515 DDPYSGHQFSFSL------------------APEA----------------ASGSN---FTIQDN 542

  Fly   998 ENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELH 1062
            :::|..:
  Rat   543 KDNTAGI---------------------------------------------------------- 549

  Fly  1063 KSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVS 1127
                                           |.|:
  Rat   550 -------------------------------LTRK------------------------------ 553

  Fly  1128 VAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLT 1192
                 :||..:|                     :..||.|      :.||       ||.|||
  Rat   554 -----NGYNRHE---------------------MSTYLLP------VVIS-------DNDYPV-- 577

  Fly  1193 VDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPL 1257
                                         |.::..:||   |:..|...|
  Rat   578 -----------------------------QSSTGTVTV---RVCACDHHG--------------- 595

  Fly  1258 QLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFS 1322
                                                              |:.| | .:.|:...
  Rat   596 --------------------------------------------------NMQS-C-HAEALIHP 608

  Fly  1323 FGIDRNFIIAIIVCLALLL--IILLAVVVQKKQKNGWHEKDI---DDIRETIINYEDEGGGERDT 1382
            .|:....::||::|:.:||  ::|.|.:.::::|    |..|   :|||:.|::|.||||||.||
  Rat   609 TGLSTGALVAILLCIVILLVTVVLFAALRRQRKK----EPLIISKEDIRDNIVSYNDEGGGEEDT 669

  Fly  1383 D-YDLNVLRTQPFYEE-KLYKD--PHALQGNMRDP--NDIPDIADFLGDKKENCDRDVGATTVDD 1441
            . :|:..||.....|: |..:|  |.||....|.|  .|..|:.||:..:.:..|.|..|...|.
  Rat   670 QAFDIGTLRNPEAMEDSKSRRDIVPEALFLPRRTPTARDNTDVRDFISQRLKENDTDPTAPPYDS 734

  Fly  1442 VRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYGEEPSDTDS 1497
            :..|||||.|:...|||||.|.|.|||.::||||::||||:|||||||...||.||
  Rat   735 LATYAYEGTGSVADSLSSLESVTTDGDQDYDYLSDWGPRFKKLADMYGGMDSDKDS 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	28/124 (23%)
		Cadherin_repeat	417..518	CDD:206637	35/107 (33%)
		Cadherin_repeat	531..619	CDD:206637	34/104 (33%)
		Cadherin_repeat	627..729	CDD:206637	25/109 (23%)
		Cadherin_repeat	736..834	CDD:206637	7/97 (7%)
		LamG	1127..1294	CDD:238058	19/166 (11%)
		Cadherin_C	1358..1489	CDD:279398	63/139 (45%)
Cdh6	NP_037059.2	CA	79..157	CDD:214520	20/77 (26%)
		Cadherin_repeat	163..264	CDD:206637	36/109 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..288		9/29 (31%)
		Cadherin_repeat	272..379	CDD:206637	35/109 (32%)
		Cadherin_repeat	388..484	CDD:206637	32/214 (15%)
		Cadherin_repeat	492..589	CDD:206637	38/360 (11%)
		Cadherin_C	637..783	CDD:395833	65/149 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910