Protein Alignment shg and Cdh7

DIOPT Version :10

• Sequence 1: NP_476722.1
• Gene: shg / 37386
• FlyBaseID: FBgn0003391
• Length: 1507
• Species: Drosophila melanogaster
• Sequence 2: NP_766441.1
• Gene: Cdh7 / 241201
• MGIID: 2442792
• Length: 785
• Species: Mus musculus
• Alignment Length: 1183
• Identity: 242/1183 - (20%)
• Similarity: 367/1183 - (31%)
• Gaps: 540/1183 - (45%)

  Fly   351 SKNTFVFNQIGNEVTISLGKTLDYEAITDYTL--TMIVRNTHE-LGTEHQIKIQVEDVNDNIPYY 412
            :.:.|:.::  |...|...|.||.|....|||  ..:.|.|:: :..|.:..|:::|:|||.|.:
Mouse    91 ASSIFIIDE--NTGDIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKF 153

  Fly   413 TE-VKSGTILENEPPGTPVMQVRAFDMD----GTSANNIVSFELADNREYFTIDPNTGNI-TALT 471
            .: ..:..:.|..|.||.|:||.|.|.|    |.||.  |.:.:...:.||:::|.||.| |||.
Mouse   154 LDGPYTAGVPEMSPVGTSVVQVTATDADDPTYGNSAR--VVYSILQGQPYFSVEPKTGVIKTALP 216

  Fly   472 TFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDA 536
            ..|||.:|.|.:.:.|.|    .:..||..: |.....:::.|.||:.|.|.:..| ...:.|..
Mouse   217 NMDREAKDQYLLVIQAKD----MVGQNGGLS-GTTSVTVTLTDVNDNPPRFPRRSY-QYNVPESL 275

  Fly   537 NTNTEVIEVKAEDED---NASQILYSIESGNVGDAFKIG----LKTGKITVNQKLDYETITEYEL 594
            ...:.|..:||.|.|   || ::.|.|..|:....|||.    .:.|.||:.::||:|..|.|.|
Mouse   276 PVASVVARIKAADADIGVNA-EMEYKIVDGDGLGIFKISADKDTQEGIITIQKELDFEAKTSYTL 339

  Fly   595 KVRAFD----------GIYDDYTTVVIKIEDVNDNPPVFKQD-YSVTILEETTYDDCILTVEAYD 648
            ::.|.:          |.:.|.|||.|.:||| |.||||... |.:.:.|.|.....|.||.|:|
Mouse   340 RIEAANRDADPRFLSLGPFSDTTTVKIIVEDV-DEPPVFSSPLYPMEVSEATQVGHIIGTVAAHD 403

  Fly   649 PDIKDRNADQHIVYSIHQN-DGNRW-TID-NSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVG 710
            ||    :::..:.|||.:| |..|: .|| |||.:...|:|||:....|....:.:::.:...||
Mouse   404 PD----SSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAVHNITVLAMESQNPSQVG 464

  Fly   711 TTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQ-LQANDYDDTPGAGNFTFGIDSE 774
            ...     |.:|:.|||||||....:......||..||.|:| :.|.|.|:......|.|.:.::
Mouse   465 RGY-----VAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLTTD 524

  Fly   775 ATPD----IKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNA 835
            .|.:    :|.........|.....|.|:.|..|::||.|.|||.|..|:
Mouse   525 MTNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSS--------------- 574

  Fly   836 MSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHT 900
                                                                             
Mouse   575 ----------------------------------------------------------------- 574

  Fly   901 AEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSP 965
                                                                             
Mouse   575 ----------------------------------------------------------------- 574

  Fly   966 DALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRL 1030
                                             .:||.:|
Mouse   575 ---------------------------------TNTLTIR------------------------- 581

  Fly  1031 ENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLM 1095
                                                                             
Mouse   582 ----------------------------------------------------------------- 581

  Fly  1096 RRCLNGGSPRYGENDVCDC-IDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQ 1159
                           |||| .||..
Mouse   582 ---------------VCDCDADGIA---------------------------------------- 591

  Fly  1160 GLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRT 1224
                                                                             
Mouse   592 ----------------------------------------------------------------- 591

  Fly  1225 SIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIR 1289
                       .||
Mouse   592 -----------QTC--------------------------------------------------- 594

  Fly  1290 NLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVC-LALLLIILLAVVVQKKQ 1353
                |.:.|.|  |:                   |:....:|||:.| |.||::|||.|.:::::
Mouse   595 ----NAEAYVL--PA-------------------GLSTGALIAILACVLTLLVLILLIVTMRRRK 634

  Fly  1354 KNGWHEKDIDDIRETIINYEDEGGGERDTD-YDLNVLRT-QPFYEEKLYKD--PHALQGNMRDPN 1414
            |......:..||||.|:.|:||||||.||: :|:..||. ....:.|..:|  |.....:.....
Mouse   635 KEPLIFDEERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNAIRDSKTRRDVTPEIQFLSRPTFK 699

  Fly  1415 DIPD---IADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSN 1476
            :|||   ..:|:.::.:..|.|.||...|.::.||:||:|:...|||||.|.:.:.|.|:||||:
Mouse   700 NIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYLSD 764

  Fly  1477 FGPRFRKLADMYG 1489
            :||||::||:|||
Mouse   765 WGPRFKRLAEMYG 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	18/61 (30%)
		Cadherin_repeat	417..518	CDD:206637	35/105 (33%)
		Cadherin_repeat	531..619	CDD:206637	33/104 (32%)
		Cadherin_repeat	627..729	CDD:206637	33/104 (32%)
		Cadherin_repeat	736..834	CDD:206637	26/102 (25%)
		LamG	1127..1294	CDD:238058	2/166 (1%)
		CADH_Y-type_LIR	1430..1489	CDD:460041	29/58 (50%)
Cdh7	NP_766441.1	CA	73..151	CDD:214520	18/61 (30%)
		Cadherin_repeat	157..258	CDD:206637	35/107 (33%)
		Cadherin_repeat	266..373	CDD:206637	34/109 (31%)
		Cadherin_repeat	382..478	CDD:206637	33/104 (32%)
		Cadherin_repeat	486..584	CDD:206637	30/380 (8%)
		CADH_Y-type_LIR	718..777	CDD:460041	29/58 (50%)