DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Cdh24

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_955764.1	Gene:	Cdh24 / 239096	MGIID:	1928330	Length:	781	Species:	Mus musculus

Alignment Length:	1070	Identity:	219/1070 - (20%)
Similarity:	353/1070 - (32%)	Gaps:	418/1070 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 FTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHF 522
            |.||..||||....:.||||:..|.:...|.|.:      :..|......|.|.:.|.||:.|.|
Mouse    92 FVIDEATGNIHVTKSLDREEKAQYVLLAQAVDRA------SNRPLEPPSEFIIKVQDINDNPPVF 150

  Fly   523 QQDKYLAERLLEDANTNTEVIEVKAEDED-----NASQILYSIESGNVGDAFKIGLKTGKI-TVN 581
            ....|.| .:.|.:|..|.||:|.|.|.|     |:::::|::..|.  ..|.:..:||.: |..
Mouse   151 PLGPYHA-TVPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGL--PFFSVDPQTGVVRTAI 212

  Fly   582 QKLDYETITEYELKVRAFD-----GIYDDYTTVVIKIEDVNDNPPVFKQD-YSVTILEETTYDDC 640
            ..:|.||..|:.:.::|.|     |.....|||.:.:.|||||||.|.|. |..:::|.......
Mouse   213 PNMDRETQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTL 277

  Fly   641 ILTVEAYDPDIKDRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVLIKAND 705
            :..::|.|||:.| ||  .:.|||...:|:.           |.::..|             :..
Mouse   278 VGRLKAQDPDLGD-NA--LVAYSILNGEGSE-----------VFSISTD-------------SQG 315

  Fly   706 EDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYDDTPGAGNFTFG 770
            :||    :.||::                   |:.::..|                    ::||.
Mouse   316 QDG----LLTVRK-------------------PLDFETRR--------------------SYTFR 337

  Fly   771 IDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNA 835
            :::       |...:|..||......|..:     :.:.:.|:..|.....:..||.:.:
Mouse   338 VEA-------TNTLIDPAYLRRGPFKDVAS-----VRVTVQDAPEPPAFTQATYHLAVPE----- 385

  Fly   836 MSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQ----FRLNPSTGMITM 896
                          .:||.|.:|::...|||......:|   ..|||..    |.:.|..|.|..
Mouse   386 --------------NKAPGTLVGQISASDLDSPASPIRY---SILPHSDPERCFSIEPEDGTIRT 433

  Fly   897 LVHTAEGEYDLSFVVTEDSMFVPRHSVDAYV----TVVVRELPEEAVDKSGSIRFINVTKEEFIS 957
            .|                     |...:|.|    |::..||
Mouse   434 AV---------------------RLDREARVWHNLTILATEL----------------------- 454

  Fly   958 VPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGI 1022
                    |:.:...|:|:::.             |:.:|:|               ||:
Mouse   455 --------DSSAQSSRVQVAIQ-------------TLDENDN---------------APQ----- 478

  Fly  1023 VAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQ 1087
                   |....|:              |.|:.:...:|.|     :|.:.....||.::.|..|
Mouse   479 -------LAEPYDI--------------FVCDSAAPGQLIK-----VIRALDRDEVGNSSQVSLQ 517

  Fly  1088 CVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLE 1152
                                         |..||.... :|.....|.|           .:.|.
Mouse   518 -----------------------------GPVGPDANF-TVRDNRDGSA-----------SLLLP 541

  Fly  1153 ITPQIDQGLIMYLGPLNFNPLLAISDFLALEL-DNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQ 1216
            ..|          .|....|.|     :.:|| |.|.|.|:
Mouse   542 SRP----------APPRQAPYL-----IPIELWDWGQPALS------------------------ 567

  Fly  1217 LDIILQRTSIEMTVDNCRLSTCQTLG--APIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVP 1279
                   ::..:||..||   |:..|  |...|.        .||..|
Mouse   568 -------STATVTVSVCR---CRPDGSMASCWPE--------AQLSPT----------------- 597

  Fly  1280 NQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCL-ALLLII 1343
                                                        |:....::||:.|: .||.::
Mouse   598 --------------------------------------------GLSTGALLAIVTCMGTLLALV 618

  Fly  1344 LLAVVVQKKQKNGWHEKDIDDIRETIINYEDEGGGERDTD-YDLNVLR-----TQPFYEEKLYKD 1402
            :|.|.::::::......:.:|:||.||.|:||||||.||: :|:..|:     ..|.....:.:|
Mouse   619 VLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDITALQNPDGAAPPAAGPPVRRD 683

  Fly  1403 --PHALQGNMRDPNDIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTD 1465
              |.........|....|:...|..:....|.|......|.|:.|.|||.|:|.||||||.|.::
Mouse   684 VLPRTRAPRQPRPPGPADVVQLLALRLREADEDPSVPPYDSVQVYGYEGRGSSCGSLSSLGSGSE 748

  Fly  1466 DGDL--NFDYLSNFGPRFRKLADMYG-EEP 1492
            .|.:  ..:.|.::||.||.||::|| :||
Mouse   749 AGGVPGPAEPLDDWGPLFRTLAELYGAKEP 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520
		Cadherin_repeat	417..518	CDD:206637	19/59 (32%)
		Cadherin_repeat	531..619	CDD:206637	29/98 (30%)
		Cadherin_repeat	627..729	CDD:206637	19/101 (19%)
		Cadherin_repeat	736..834	CDD:206637	13/97 (13%)
		LamG	1127..1294	CDD:238058	25/169 (15%)
		Cadherin_C	1358..1489	CDD:279398	47/140 (34%)
Cdh24	NP_955764.1	CA	70..148	CDD:214520	20/61 (33%)
		Cadherin_repeat	154..255	CDD:206637	31/103 (30%)
		Cadherin_repeat	264..368	CDD:206637	28/185 (15%)
		Cadherin_repeat	378..475	CDD:206637	29/183 (16%)
		Cadherin	485..577	CDD:356102	28/197 (14%)
		Cadherin_C	625..776	CDD:366437	49/150 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..700		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..762		13/30 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000