DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Cdh19

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_001074855.1	Gene:	Cdh19 / 227485	MGIID:	3588198	Length:	770	Species:	Mus musculus

Alignment Length:	1110	Identity:	237/1110 - (21%)
Similarity:	371/1110 - (33%)	Gaps:	459/1110 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 DMDGTSANNIVSFELAD-NREYFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGE 500
            |:|  :.||...::|.. ....|:|:..||.|.|:...||||:..|.::....|.:      .|:
Mouse    68 DLD--NGNNSFQYKLLGIGAGSFSINERTGEICAIQKLDREEKSLYILRAQVIDTT------IGK 124

  Fly   501 PNRGHQVFRISIGDKNDHKPHFQQDKYLAERLL-EDANTNTEVIEVKAEDEDNAS-----QILYS 559
            .......|.|.:.|.||::|.|..:.|  |.:: |.:...|.||:|.|.|.|:.|     :|||:
Mouse   125 AVETESEFVIRVLDINDNEPRFLDEPY--EAIVPEMSPEGTFVIKVTANDADDPSTGYHARILYN 187

  Fly   560 IESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFD-----GIYDDYTTVVIKIEDVNDN 619
            :|.|.  ..|.:...||.|.::.|:|.|....|.:.::|.|     |.....|||.||:.|:|||
Mouse   188 LERGQ--PYFSVEPTTGVIRISSKMDRELQDTYCVIIQAKDMLGQPGALSGTTTVSIKLSDINDN 250

  Fly   620 PPVFKQD-YSVTILEETTYDDCILTVEAYDPDIKDRNADQHIVYSIHQNDGNRW--TIDN---SG 678
            .|:||:. |..||.|.......|..:.|||.||.: ||:..  |||..:|...:  .|||   .|
Mouse   251 KPIFKESFYRFTISESAPIGTSIGKIMAYDDDIGE-NAEME--YSIEDDDSKIFDIIIDNDTQEG 312

  Fly   679 CLRLVKTLDRDPPNGH------KNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEM 737
            .:.|.|.:|.:..:.:      ||..|     ||                     :.||..:|..
Mouse   313 IVILKKKVDFEQQSYYGIRAKVKNCHV-----DE---------------------ELAPAHVNAS 351

  Fly   738 PVYWQENRNPGHVVQLQANDYDDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQK 802
            ..|          :::|..|.|:.|
Mouse   352 TTY----------IKVQVEDEDEPP---------------------------------------- 366

  Fly   803 EYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDD 867
            .:.:|..|.:  :|                                :|:...|.:|.|...|.|.
Mouse   367 VFLLPYYILE--IP--------------------------------EGKPYGTIVGTVSATDPDR 397

  Fly   868 WDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVR 932
                              |.:|                 :.:.:|...||    .::...|::..
Mouse   398 ------------------RQSP-----------------MRYYLTGSKMF----DINDNGTIITT 423

  Fly   933 ELPEEAVDKSGSIRF-INVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQ 996
            .:    :|:..|..: :.||..|..:|.               |:|.|.::      |.||.:
Mouse   424 NM----LDREVSAWYNLTVTATETYNVQ---------------QISSAHVY------VQVFNI-- 461

  Fly   997 NENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNEL 1061
            |:|               |||     .:|                     ..|.:.||.:.:.|:
Mouse   462 NDN---------------APE-----FSQ---------------------FYETYVCENAESGEI 485

  Fly  1062 HKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDCID---GFTGPHC 1123
                                  ||                         :...||   .....|
Mouse   486 ----------------------VQ-------------------------IISAIDRDESIEDHH- 502

  Fly  1124 ELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFN----PLLAISDFLALEL 1184
                  ||     |...:...||:  |..:|...|...::......||    |:..:   :.|..
Mouse   503 ------FY-----FNHSLEDTNNS--SFMLTDNQDNTAVILSNRTGFNLKEEPVFYM---IILIA 551

  Fly  1185 DNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNE 1249
            |||.|.||                               ::..:|:..|   .|
Mouse   552 DNGIPSLT-------------------------------STNTLTIQVC---DC----------- 571

  Fly  1250 FLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQ 1314
                                                |..||   .|...|.|:
Mouse   572 ------------------------------------GDSRN---TETCANKGL------------ 585

  Fly  1315 QSVAVAFSFGIDRNFIIAIIVCLALL--LIILLAVVVQKKQKNGWHEKDIDDIRETIINYEDEGG 1377
                 .|..|.....||||::|:.::  ...|:..:.|::::..:.|| .:|.||.|..|:||||
Mouse   586 -----LFIMGFRTEAIIAIMICVMVIFGFFFLILALKQRRKETLFPEK-TEDFRENIFCYDDEGG 644

  Fly  1378 GERDTD-YDLNVLRTQPFYEEK------------LYKDPHALQGNMRDPNDIPDIA---DFLGDK 1426
            ||.|:: :|:..||......|:            ||:  .:||..       ||.|   .|:.:|
Mouse   645 GEEDSEAFDIVELRQSTVMRERKPQRSKSAEIRSLYR--QSLQVG-------PDSAIFRKFILEK 700

  Fly  1427 KENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYGE- 1490
            .|..:.|..|...|.::.:||||.|:|.||||||||...|.:.:||||::.||||::||.|:|.
Mouse   701 LEEANTDPCAPPFDSLQTFAYEGTGSSAGSLSSLASRDTDQEDDFDYLNDLGPRFKRLASMFGSA 765

  Fly  1491 -EPSD 1494
             :|::
Mouse   766 VQPNN 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520
		Cadherin_repeat	417..518	CDD:206637	22/81 (27%)
		Cadherin_repeat	531..619	CDD:206637	32/98 (33%)
		Cadherin_repeat	627..729	CDD:206637	28/112 (25%)
		Cadherin_repeat	736..834	CDD:206637	8/97 (8%)
		LamG	1127..1294	CDD:238058	24/170 (14%)
		Cadherin_C	1358..1489	CDD:279398	57/146 (39%)
Cdh19	NP_001074855.1	Cadherin_repeat	50..142	CDD:206637	22/81 (27%)
		Cadherin_repeat	150..250	CDD:206637	34/103 (33%)
		Cadherin_repeat	259..364	CDD:206637	34/143 (24%)
		Cadherin_repeat	373..464	CDD:206637	27/190 (14%)
		Cadherin_repeat	472..570	CDD:206637	29/195 (15%)
		Cadherin_C	617..764	CDD:395833	58/156 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910