DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shg and Dsg1b

DIOPT Version :9

Sequence 1:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster
Sequence 2:NP_859010.1 Gene:Dsg1b / 225256 MGIID:2664357 Length:1060 Species:Mus musculus


Alignment Length:1236 Identity:231/1236 - (18%)
Similarity:371/1236 - (30%) Gaps:540/1236 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   372 LDYEA--ITDYTLTMIVRNTHELGTEHQIKIQVEDVNDNIPYYTEVKSGTIL------------- 421
            :|:.:  |....||.:|  ..|:.:|.|  |||.|.|        .|:|||.             
Mouse     1 MDWHSFRIAALLLTSLV--VLEVNSEFQ--IQVRDHN--------AKNGTIKWHSIRRQKREWIK 53

  Fly   422 --------ENEPPGTPVMQVRAFDMDGTSANNIVSFELA----DNREY--FTIDPNTGNITALTT 472
                    |:.....|:.::.:    ..:||..|::.::    |...|  |.|:..||.|...:.
Mouse    54 FAAACREGEDNSKRNPIAKIHS----DCAANQPVTYRISGVGIDQPPYGIFIINQKTGEINITSI 114

  Fly   473 FDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDAN 537
            .|||...|:.:...|       |...|:........|:.:.|.||:.|.|....:|.: :.|::|
Mouse   115 VDREVTPFFIIYCRA-------LNAQGQDLENPLELRVRVMDINDNPPVFSMTTFLGQ-IEENSN 171

  Fly   538 TNTEVIEVKAEDEDNA----SQILYSIESGNVGDA--FKIGLKTGKI-TVNQKLDYETITEYELK 595
            .||.|:::.|.|.|..    |.|.:.|......|:  |.|..|||:| |:|..||.|..::|.|.
Mouse   172 ANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEIRTMNNFLDREQYSQYSLV 236

  Fly   596 VRAF--DGIYDDYTT---VVIKIEDVNDNPPVFKQ-DYSVTILEETTYDDCILTVEAYDPDIKDR 654
            ||..  ||..|..:.   ..|.|.|||||.|..:| .|.:.| ||......::.:...|.|.:..
Mouse   237 VRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDIEI-EENALHSQLVQIRVIDLDEEFS 300

  Fly   655 NADQHIVYSIHQNDGNRWTID-----NSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVS 714
            :..:.|::.|..|:||.:.|:     |.|.|::||.||.:   ..||.|:.|      ||.....
Mouse   301 DNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDYE---AMKNLQLSI------GVRNVAE 356

  Fly   715 -----------TVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYDDTPGAGNFT 768
                       |...||||:.::.:.:.|             .|                 |:.|
Mouse   357 FHQSIISQYRLTATMVTVTVLNVIEGSVF-------------RP-----------------GSKT 391

  Fly   769 FGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVND 833
            |.:||.               :.||                               |.|      
Mouse   392 FVVDSR---------------MEAN-------------------------------HRV------ 404

  Fly   834 NAMSEGSSRIFIYNYKGE--APETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITM 896
                            ||  |.:.|.||...         :..:|..:.|.:...::..||:||:
Mouse   405 ----------------GEFVATDLDTGRAST---------NVRYEMGNNPENLLVVDSRTGIITL 444

  Fly   897 LVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRD 961
                                   |:                           .||.|::..:..:
Mouse   445 -----------------------RN---------------------------RVTMEQYQRLNGE 459

  Fly   962 FQSPDALSLKDRLQLS-----LAKLFNT--------------SVSNVDVFTVLQNENHTLDVRFS 1007
            ::. ..||:.|.||.:     :.:|..|              |..|.|            .|...
Mouse   460 YKG-TVLSIDDSLQRTCTGTIVIELSGTGWVPGSDGGGSSSGSGGNRD------------PVTNG 511

  Fly  1008 AHGSPYYAPEKL----------NGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELH 1062
            ..|:....|:::          .|....|....:|.||                          .
Mouse   512 YQGTSTVGPQRVTGSGGVTSSGGGSGVNNTPGRQNPLD--------------------------E 550

  Fly  1063 KSSVPYMIYSNTTSF--VGVNAFVQAQCVCE-APLMRRCLNGGSPRYGENDVCDCIDGFTGPHCE 1124
            ....|:.|..:...|  .|:...:....|.. .|.:..|             ||| .|..|    
Mouse   551 PEPEPFDITEDNVHFGPAGIGLLIMGFLVLGLVPFLLIC-------------CDC-GGAPG---- 597

  Fly  1125 LVSVAFYGSGYAFYEPIAACNNTKI---SLE-ITPQIDQGL----IMYLGPLNFNPLLAISDFLA 1181
                     |.|.:||:..|::..|   ::| ..|:...|:    :..:.|.|.|          
Mouse   598 ---------GGAGFEPVPECSDGAIHTWAIEGPQPEPHDGITTICVPQMPPGNAN---------- 643

  Fly  1182 LELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPIG 1246
                      .::|                                  :||..:.|         
Mouse   644 ----------VIEY----------------------------------IDNSGVYT--------- 655

  Fly  1247 PNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDS 1311
             ||:                  .||::               ::|...|:|...   .:...:.:
Mouse   656 -NEY------------------CGREM---------------QDLGGGERTTGF---ELMDGVKT 683

  Fly  1312 GCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQKNGWHEKDIDDIRETIINYEDEG 1376
            .....:...:|..:.||                                   .:||.        
Mouse   684 SAAPEICQEYSGTLRRN-----------------------------------SMREC-------- 705

  Fly  1377 GGERDTDYDLNVLRTQPFYEEKLYKDPHALQGNMRDPNDIPDIADFLGDKKENCDRDVGATTVDD 1441
               ||...::|.:  :.::.:|.|                           ...|.|.|..:.|.
Mouse   706 ---RDGGLNMNFM--ESYFCQKAY---------------------------AYADEDEGRPSNDC 738

  Fly  1442 VRHYAYEGDGNSDGSLSSLASCTDDG-DLNFDYLSNFGPRFRKLADM-YGEEPSDTDSNVDDDQG 1504
            :..|..||.|:..|   |:..|:..| ||:..:|...||:|:||||: .|:|   .||..|.|..
Mouse   739 LLIYDIEGVGSPAG---SVGCCSFIGEDLDESFLDTLGPKFKKLADISLGKE---IDSYPDPDSS 797

  Fly  1505 W 1505
            |
Mouse   798 W 798

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637
Cadherin_repeat 200..292 CDD:206637
CA 332..410 CDD:214520 13/39 (33%)
Cadherin_repeat 417..518 CDD:206637 25/127 (20%)
Cadherin_repeat 531..619 CDD:206637 35/99 (35%)
Cadherin_repeat 627..729 CDD:206637 30/117 (26%)
Cadherin_repeat 736..834 CDD:206637 10/97 (10%)
LamG 1127..1294 CDD:238058 21/174 (12%)
Cadherin_C 1358..1489 CDD:279398 29/132 (22%)
Dsg1bNP_859010.1 CA 73..155 CDD:214520 21/92 (23%)
Cadherin_repeat 165..265 CDD:206637 35/100 (35%)
Cadherin_repeat 273..379 CDD:206637 30/115 (26%)
Cadherin_repeat 391..483 CDD:206637 29/219 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 490..560 13/107 (12%)
Cadherin_C 667..782 CDD:279398 33/195 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 792..811 3/7 (43%)
Desmoglein repeat 1 835..861
Desmoglein repeat 2 862..891
Desmoglein repeat 3 892..921
Desmoglein repeat 4 922..949
Desmoglein repeat 5 950..978
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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