DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Cdh12

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_001008420.1	Gene:	Cdh12 / 215654	MGIID:	109503	Length:	794	Species:	Mus musculus

Alignment Length:	1161	Identity:	254/1161 - (21%)
Similarity:	397/1161 - (34%)	Gaps:	451/1161 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 LGTEHQIKIQVEDVNDNIPYYTEVKSG------TILENEPPGTPVMQVRAFDMDGTSANNIVSFE 450
            |.||.  |..|..::....::..||.|      .:|| |..|:....|.....|.......|.:.
Mouse    31 LATEP--KENVIHLSGRRSHFQRVKRGWVWNQFFVLE-EYMGSEPQYVGKLHSDLDKGEGTVKYT 92

  Fly   451 LADN--REYFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIG 513
            |:.:  ...||||..||:|.|:.:.||||:.||.::..|.|      .:..:|......|.|.:.
Mouse    93 LSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVD------IETRKPLEPESEFIIKVQ 151

  Fly   514 DKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDED-----NASQILYSIESGNVGDAFKIGL 573
            |.||::|.|....|:|. :.|.:.....|::|||.|.|     |:::::|||..|.  ..|.|..
Mouse   152 DINDNEPKFLDGPYVAS-VPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQ--PYFSIDP 213

  Fly   574 KTGKI-TVNQKLDYETITEYELKVRAFD-----GIYDDYTTVVIKIEDVNDNPPVF-KQDYSVTI 631
            |||.| |....:|.|...:|::.::|.|     |.....|.|.|.:.|||||||.| |..:.:.:
Mouse   214 KTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTVVNITLTDVNDNPPRFPKSIFHLKV 278

  Fly   632 LEETTYDDCILTVEAYDPDIKDRNADQHIVYSIHQND-GNRWTI-----DNSGCLRLVKTLDRDP 690
            .|.:.....|..:.|.|||. .:||:  |.|:|...| ||.:.|     ...|.::|.|.||.:.
Mouse   279 PESSPVGSAIGRIRAVDPDF-GKNAE--IEYNIVPGDGGNLFDIVTDEDTQEGIIKLKKPLDFET 340

  Fly   691 PNGHKNWQVLIKAND--------EDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNP 747
               .|.:...::|::        ..|.....:|||   :::.|:::...|   ..|:|..|
Mouse   341 ---KKAYTFKVEASNLHLDHRFHSAGPFKDTATVK---ISVLDVDEPPVF---SKPLYTME---- 392

  Fly   748 GHVVQLQANDYDDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISD 812
                     .|:|||
Mouse   393 ---------VYEDTP-------------------------------------------------- 398

  Fly   813 SGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEW 877
                       :..:||.|....:..|||.:               |.|:|             |
Mouse   399 -----------VGTIIGAVTAQDLDVGSSAV---------------RYFID-------------W 424

  Fly   878 KDLPHDQFRLNPSTGMIT---MLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVV-VRELPEEA 938
            |......|.::.:.|.|.   :|......:|:.|.:.::.|..:....|:..:.|: |.|.|.|
Mouse   425 KSDGESYFTIDGTEGTIATNELLDRENMAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPE- 488

  Fly   939 VDKSGSIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSV-SNVDVFTVLQNENHTL 1002
                             ||||                      :.|:| .|.....::|... .:
Mouse   489 -----------------ISVP----------------------YETAVCENAKPGQIIQIVG-AV 513

  Fly  1003 DVRFSAHGSPY---YAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKS 1064
            |...|..|..:   .|||   .::..|
Mouse   514 DRDLSPAGQQFSFRLAPE---AVIKPN-------------------------------------- 537

  Fly  1065 SVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVA 1129
               :.::....:..|:..             ||  ||.|.|..|
Mouse   538 ---FTVHDFRNNTAGIET-------------RR--NGYSRRQQE--------------------- 563

  Fly  1130 FYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVD 1194
                                                  |.|.|::       :| |:.|||
Mouse   564 --------------------------------------LYFLPIV-------IE-DSSYPV---- 578

  Fly  1195 YGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQL 1259
                                       |.::..||:..||   |.:.|.
Mouse   579 ---------------------------QSSTNTMTIRVCR---CDSDGT---------------- 597

  Fly  1260 GGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFG 1324
                                    ...|                    |::       |:....|
Mouse   598 ------------------------ILSC--------------------NVE-------AIFLPVG 611

  Fly  1325 IDRNFIIAIIVCLALLLIILLAVVVQKKQKNGWHEKDI-----DDIRETIINYEDEGGGERDTD- 1383
            :....:|||::|:.:||.|::..|..::|:    :||.     :|||:.:|:|:||||||.||.
Mouse   612 LSTGALIAILLCMVILLAIVVLYVALRRQR----KKDTLMTSKEDIRDNVIHYDDEGGGEEDTQA 672

  Fly  1384 YDLNVLRTQPFYEE-KLYKD--PHALQGNMRDP--NDIPDIADFLGDKKENCDRDVGATTVDDVR 1443
            :|:..||.....|| |:.:|  |.:|..:.:.|  .|..||.||:..:.:..|.|..|...|.:.
Mouse   673 FDIGALRNPKVIEENKIRRDIKPDSLCLSRQRPQVEDNTDIRDFIHRRLQENDADPAAPPYDSLA 737

  Fly  1444 HYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYGEEPSDTDSNV 1499
            .|||||:|:...||||:.|.|.:.|.::||||::||||:.||||:|||.|....||
Mouse   738 TYAYEGNGSVAESLSSIDSLTTEADQDYDYLSDWGPRFKVLADMFGEEESYNPDNV 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	5/17 (29%)
		Cadherin_repeat	417..518	CDD:206637	30/108 (28%)
		Cadherin_repeat	531..619	CDD:206637	31/98 (32%)
		Cadherin_repeat	627..729	CDD:206637	27/115 (23%)
		Cadherin_repeat	736..834	CDD:206637	10/97 (10%)
		LamG	1127..1294	CDD:238058	16/166 (10%)
		Cadherin_C	1358..1489	CDD:279398	59/141 (42%)
Cdh12	NP_001008420.1	CA	80..158	CDD:214520	25/83 (30%)
		Cadherin_repeat	164..265	CDD:206637	33/103 (32%)
		Cadherin_repeat	273..380	CDD:206637	27/115 (23%)
		Cadherin_repeat	389..484	CDD:206637	27/196 (14%)
		Cadherin_repeat	492..590	CDD:206637	31/277 (11%)
		Cadherin_C	638..785	CDD:395833	61/150 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910