DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Dsg1c

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_859008.1	Gene:	Dsg1c / 211924	MGIID:	2664358	Length:	911	Species:	Mus musculus

Alignment Length:	1201	Identity:	240/1201 - (19%)
Similarity:	373/1201 - (31%)	Gaps:	522/1201 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 LDYEA--ITDYTLTMIVRNTHELGTEHQIKIQVEDVNDNIPYYTEVKSGTIL------------- 421
            :|:.:  |....||.:|  ..|:.:|.|  |||.|.|        .|:|||.
Mouse     1 MDWHSFRIAALLLTSLV--VLEVNSEFQ--IQVRDHN--------AKNGTIKWHSIRRQKREWIK 53

  Fly   422 --------ENEPPGTPVMQVRAFDMDGTSANNIVSFELA----DNREY--FTIDPNTGNITALTT 472
                    |:.....|:.::.:    ..:||..|::.::    |...|  |.|:..||.|...:.
Mouse    54 FAAACREGEDNSKRNPIAKIHS----DCAANQPVTYRISGVGIDQPPYGIFIINQKTGEINITSI 114

  Fly   473 FDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDAN 537
            .|||...|:.:...|       |...|:........|:.:.|.||:.|.|....:|.: :.|::|
Mouse   115 VDREVTPFFIIYCRA-------LNAQGQDLENPLELRVRVMDINDNPPVFSMTTFLGQ-IEENSN 171

  Fly   538 TNTEVIEVKAEDEDNA----SQILYSIESGNVGDA--FKIGLKTGKI-TVNQKLDYETITEYELK 595
            .||.|:::.|.|.|..    |.|.:.|......|:  |.|..|||:| |:|..||.|..::|.|.
Mouse   172 ANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFTINRKTGEIRTMNNFLDREQYSQYSLV 236

  Fly   596 VRAF--DGIYDDYTT---VVIKIEDVNDNPPVFKQ-DYSVTILEETTYDDCILTVEAYDPDIKDR 654
            ||..  ||..|..:.   ..|.|.|||||.|..:| .|.:|| ||.|....:|.:...|.|.:..
Mouse   237 VRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDITI-EENTLHSQLLQIRVIDLDEEFS 300

  Fly   655 NADQHIVYSIHQNDGNRWTID-----NSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVS 714
            :..:.|::.|..|:||.:.|:     |.|.|::||.||.:   ..||.|:.|...:......::.
Mouse   301 DNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDYE---AVKNLQLCIGVRNVAEFHQSII 362

  Fly   715 TVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYDDTPGAGNFTFGIDS--EATP 777
            :...:||||..:.     ::|.:         .|.|.|           .|:.||.:||  ||..
Mouse   363 SQYRLTVTLITVT-----VLNVV---------KGCVFQ-----------PGSKTFIVDSRMEANH 402

  Fly   778 DIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSR 842
            .:       |::|..:.:..:...|  |..:|              ...|:|:..:|.:...|..
Mouse   403 TV-------GEFLATDCETGQATNK--FKNVR--------------YRYVMGNNPENLLVVDSGI 444

  Fly   843 IFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLP-HDQFRLNPSTGMITMLVHTAEGEYD 906
            |.:.|           ||   .::.::..:|.:|...|. ||..: ...||.|.|::
Mouse   445 ITLRN-----------RV---TMEQYERLNKRYEGTVLSIHDSLQ-RTCTGTIIMVL-------- 486

  Fly   907 LSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPDALSLK 971
            ..|..|                   .|.|..:.:|                       |..||:
Mouse   487 CGFWTT-------------------TEHPTTSTEK-----------------------PVTLSI- 508

  Fly   972 DRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRLENELDL 1036
                          ..|||            :|.|...|.         |:           |.:
Mouse   509 --------------TPNVD------------NVHFGPAGI---------GL-----------LIM 527

  Fly  1037 QMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNG 1101
            ..|::.:                      ||:::.|               |.|          |
Mouse   528 GFLVLGL----------------------VPFLLIS---------------CDC----------G 545

  Fly  1102 GSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLG 1166
            |:|                            .|.|.:||:..|::
Mouse   546 GAP----------------------------GGGAGFEPVPECSD-------------------- 562

  Fly  1167 PLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVD 1231
                                           |||            .|:.::
Mouse   563 -------------------------------GAI------------HTWAVE------------- 571

  Fly  1232 NCRLSTCQTLGAPIGPNEFLNVNAPLQLGG-TPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINE 1295
                          ||          |.|| |.:.:.|:        .|.         |..:.|
Mouse   572 --------------GP----------QPGGITTICVPQM--------PPG---------NANVIE 595

  Fly  1296 QTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQKNGWHEK 1360
            ...|.|   |:.|...|
Mouse   596 YIDNSG---VYTNEYCG------------------------------------------------ 609

  Fly  1361 DIDDIRETIINYEDEGGGERDTDYDL-NVLRTQPFYEEKLYKDPHALQ---GNMRDPNDIPDIAD 1421
                 ||    .:|.|||||.|.::| :.::|.        ..|...|   |.:| .|.:.:..|
Mouse   610 -----RE----MQDLGGGERTTGFELMDGVKTS--------AAPEICQEYSGTLR-RNSMRECRD 656

  Fly  1422 -----------FLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLS 1475
                       |........|.|.|..:.|.:..|..||.|:..|   |:..|:...||:..:|.
Mouse   657 GGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAG---SVGCCSFIEDLDESFLD 718

  Fly  1476 NFGPRFRKLADM-YGEEPSDTDSNVDDDQGW 1505
            ..||:|:||||: .|:|   .||..|.|..|
Mouse   719 TLGPKFKKLADISLGKE---IDSYPDPDPSW 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	13/39 (33%)
		Cadherin_repeat	417..518	CDD:206637	25/127 (20%)
		Cadherin_repeat	531..619	CDD:206637	35/99 (35%)
		Cadherin_repeat	627..729	CDD:206637	30/106 (28%)
		Cadherin_repeat	736..834	CDD:206637	17/99 (17%)
		LamG	1127..1294	CDD:238058	18/167 (11%)
		Cadherin_C	1358..1489	CDD:279398	39/146 (27%)
Dsg1c	NP_859008.1	CA	73..155	CDD:214520	21/92 (23%)
		Cadherin_repeat	165..265	CDD:206637	35/100 (35%)
		Cadherin_repeat	273..379	CDD:206637	30/114 (26%)
		Cadherin_C	616..730	CDD:279398	35/125 (28%)
		Desmoglein repeat 1	783..809
		Desmoglein repeat 2	810..839
		Desmoglein repeat 3	840..869
		Desmoglein repeat 4	870..897
		Desmoglein repeat 5, truncated	898..911
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000