DRSC/TRiP Functional Genomics Resources

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Protein Alignment shg and cdh-1

DIOPT Version :10

Sequence 1:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster
Sequence 2:NP_497641.2 Gene:cdh-1 / 187783 WormBaseID:WBGene00019994 Length:2779 Species:Caenorhabditis elegans


Alignment Length:1678 Identity:362/1678 - (21%)
Similarity:587/1678 - (34%) Gaps:481/1678 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 SGDNRKPAFKNCAGYAPKVKEEQPENTYVLTVEAVDPD--PDQVIRYSIVQSPFERPKFFINPST 141
            :.|| .|.|.. :.|...|.......::::||:|.|.|  .:..|.|.|.::.......|....:
 Worm   226 ANDN-APVFSR-SRYTASVSANISIGSHLITVQATDADIGENSRISYDIKKTSAPSNSNFAISQS 288

  Fly   142 GVIFTTHTF-------------DRDEPIHEKFVFVTVQATDNGL--PPLDDVCTFN--------- 182
            |||.||.:.             |...|.......||:....:.|  ||||.:....         
 Worm   289 GVITTTASLLPASTHDVIVVASDHGSPSLSSSAVVTITVLGSTLSSPPLDIIWLVESNSAHLMEN 353

  Fly   183 ----------------------------------------------------------------- 182
                                                                             
 Worm   354 STLGSIVARVSIAQQYRDTKLRLIGSSALCPQQTDQAHVYLLLLCGILDRETASEHHLKFLLEKD 418

  Fly   183 ----------VTIEDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDDGNNSLVEYEILRE 237
                      :||.|||||||.::.::...|::   :......|::|.|.|.|.|..:.|.:|  
 Worm   419 GQIIIEHPQLLTIGDINDNAPQWHSSQIHISLN---RTQGGSRTLTAKDPDLGQNGWIRYSVL-- 478

  Fly   238 RDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPDPPQDAQIEVRIRVVESSIKPPSFV 302
             |.:...||||:|.|::...||...|......|||.: ...|.....::|...::::..|||.|.
 Worm   479 -DTELVSIDKETGRIFVPNTIDCNIGSEIKFRVRAED-GGSPALSTDLQVVADLLDTESKPPQFE 541

  Fly   303 N-------PIDTPIYLKENLKNFTHPIATLRAVSN---MPDKPEVIFELNTGRTEQTNSKNTFVF 357
            .       |.||||           ....::.|:|   ..:...:.:.|      |...::..|.
 Worm   542 KALWQVEIPEDTPI-----------GTCLVKVVANNSQCGNSKRIRYSL------QNQDEHLTVD 589

  Fly   358 NQIGNEVTISLGKTLDYEAITDYTLTMIVRNTHELGTEHQIKIQVEDVNDNIP-YYTEVKSGTIL 421
            ...|   |:.:.||.|:|....|..|:|..|.:...:...|.|:::|||||.| :|......|:.
 Worm   590 TMSG---TVCIQKTFDFEKQKSYQTTVIATNANSETSTSLISIRLKDVNDNWPIFYPNEYHLTVR 651

  Fly   422 ENEPPGTPVMQVRAFDMD-GTSANNIVSFELADNREYFTIDPNTGNITALTTFDREERDFYNVKV 485
            |...|..|::.|.|.||| ||...  ||:.:......|:|:|.||.:.|.....|..   :::.|
 Worm   652 EGPKPEEPLLVVSASDMDSGTFGE--VSYHILSESSSFSINPVTGEVFAQKPLARGR---FHLVV 711

  Fly   486 IASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDE 550
            .|.|.       .|:.:.......|::.||:...|.|.:.|| ..|..||......:..|.|   
 Worm   712 SAKDG-------GGQSSENSANIHITVIDKDTKTPQFSRSKY-EIRTTEDILPGIAIGSVGA--- 765

  Fly   551 DNASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRA-FDGIYDDYTTVVIKIE 614
              .|::.|||.||:....|.|...||||.|.:.||.:......|.::| ......:.|.|||.||
 Worm   766 --MSKVKYSIYSGDQDHNFSIDEDTGKIYVTRYLDADVHDTVLLNIQATLPSGESNQTQVVIFIE 828

  Fly   615 DVNDNPPVFKQD-YSVTILEETTYDDCILTVEAYDPDIKDRNADQHIVYS-IHQNDGNRWTIDN- 676
            |.|||||.|... ..::|.|:....:....|:|.|   ||:..:..:.|| |..:.|:...||. 
 Worm   829 DHNDNPPQFSSSLVEISIREDLKLHEPFYVVQASD---KDKKKNGEVRYSIISSHPGSSIEIDQF 890

  Fly   677 SGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYW 741
            :|.|.....||.:   ..:|:::.:||.|. |:....|.: .:.:.:.|:|||||    |....|
 Worm   891 TGQLSTGSLLDYE---ATRNYKLRVKATDL-GIPPRSSNM-TLFIHVLDVNDNAP----EFEKSW 946

  Fly   742 Q-----ENRNPGHVV-QLQANDYDDTPGA--------GNFTFGIDSEATPDIKTKFSMDGDYLHA 792
            .     ||..|..:| ::.|.|.|.....        |:..|||| |...::.||.|:       
 Worm   947 YTMEVLENSPPKTIVGKVVARDKDSLENGQIVYRITNGSEYFGID-EKLGNVYTKRSI------- 1003

  Fly   793 NVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDI 857
                |||......|.|...|.|||.:|:.:...:.:.|||||..|..|....:.. .|....|.|
 Worm  1004 ----DREVISHVDISIVAEDKGVPPRSSTASARISVLDVNDNPPSCLSITPIVVP-AGSPLSTAI 1063

  Fly   858 GRVFVDDLDDW---------DLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFVVTE 913
            |.:...|.|..         .|:...|..|.        |....:...|..:.|....||.:|::
 Worm  1064 GTIVAMDPDKGLNGSVLYRAQLQSSLFVVKS--------NGDVYLRRQLNASDERHQRLSVIVSD 1120

  Fly   914 DSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPDALSLKDRLQLSL 978
            ..  |||.||..:|.|        .:.|..:...|....:::|.:|:...:...|:..:...:|.
 Worm  1121 QG--VPRKSVVCHVPV--------RISKGSADIQIQEPFQKYIEIPKSCPTGCRLTTLNATGVSS 1175

  Fly   979 AKLFNTSVSN--------------------VDVFTVLQNEN---HTLDVRFSAHGSPYYAPEKLN 1020
            ..:.::.:||                    ..:..||.::|   .::.:|..|.|.         
 Worm  1176 WLIQSSEISNHFAIREGVLFMISHPIHRPPYSLVIVLSDKNDRQKSIQLRVLASGE--------- 1231

  Fly  1021 GIVAQNQQRLENELDLQMLMVNI--------DECLIEKFKCEESCTNELHKSSVPYMIYSNTTSF 1077
               |.|::......|...:...|        |.....:|..||||..||.::.  .::|.     
 Worm  1232 ---AANKEETIRISDSNSIGTKIGRLGEKSADGSFFYRFSSEESCPLELDQTG--GLLYL----- 1286

  Fly  1078 VGVNAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPI- 1141
                          |..:||         |:.....|                      |:|.. 
 Worm  1287 --------------ADGLRR---------GDTHNFSC----------------------FFEKFN 1306

  Fly  1142 ---AACNNTKISLEIT------PQIDQGLIMY-------LGPLNFNPLLAISDFLALELDNGYPV 1190
               .:....::.|||:      |:.|.|.:..       .|.:.......:||..|..:...:|:
 Worm  1307 TTDGSAEEMRVDLEISRTKSDKPRFDTGHLRVNIREDTPTGSIITTVNATVSDDSASPISYRFPL 1371

  Fly  1191 L----TVDYGSGAIRI---RHQHIKMVADRTYQLDIILQRTS-------IEMTVDNCRLSTCQTL 1241
            |    ::|..:|.|.:   .|.|:    ..||.| |:...||       :.:.||:....|...:
 Worm  1372 LIDNFSIDQFTGDITLIDTLHWHV----TPTYNL-IVEAFTSGPGTTLLVTVNVDDVNDHTPFIV 1431

  Fly  1242 GAP--IGPNEFLNVNAPLQLGG-----TPVDLE---QLGRQLNWTHVPNQKGFFGCIRNLTINEQ 1296
            ..|  :.|:.:       :.||     ..:||:   ::...|.:......|.||      .|:|:
 Worm  1432 SQPTVLLPSSY-------RKGGMVHRVVAIDLDKDPEIRYSLKYAGSEVAKEFF------KIDEK 1483

  Fly  1297 TYNLGMPSVFRNIDSGCQQSVAVAFSF---GIDRNFIIAIIVCLALLLI----ILLAVVVQKKQK 1354
            :..:.:          .:.|.|::.||   |:.....|.......|...    :||.  .....:
 Worm  1484 SGEIFV----------VESSSALSTSFGGAGLPETLTIRATDLQDLTKFDEQKVLLK--ASNASR 1536

  Fly  1355 NGWH-----EKDIDDIRETIINYEDEGGGERDTDY----DLNVLRTQPFYEEK----LYKDPHAL 1406
            :.||     .||:     ||::...:|.......:    ||.::.:.|.:|.|    :.|.....
 Worm  1537 STWHFFDEQHKDV-----TILSTSPQGSQILQLKFQEGVDLQLIPSSPHFELKSSKIVQKSASVA 1596

  Fly  1407 QGNMR--------------------DP--NDIPDIADFLGDKKENC-----DRDVG--------A 1436
            .|..|                    :|  .:.|.|:      ..:|     :.:||        |
 Worm  1597 TGTQRFTIVAQKDDELDYSTLKIHVEPVFTEPPKIS------STSCGVVTIEENVGIEDFKRILA 1655

  Fly  1437 TTVDDVRHYAYEGD------GNSDGSLSSL-----AS--------CTDDGDLN 1470
            |.:.:...:.::|:      .::.||:|.|     ||        .||.|..|
 Worm  1656 TGMTEESRFRFQGNAPKFSINSTTGSISVLPLDREASQEHLLIIILTDGGSRN 1708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637 30/198 (15%)
Cadherin_repeat 200..292 CDD:206637 24/91 (26%)
CA 332..410 CDD:214520 20/77 (26%)
Cadherin_repeat 417..518 CDD:206637 27/101 (27%)
Cadherin_repeat 531..619 CDD:206637 30/88 (34%)
Cadherin_repeat 627..729 CDD:206637 25/103 (24%)
Cadherin_repeat 736..834 CDD:206637 31/111 (28%)
LamG 1127..1294 CDD:238058 38/207 (18%)
CADH_Y-type_LIR 1430..1489 CDD:460041 16/73 (22%)
cdh-1NP_497641.2 Cadherin_repeat 29..118 CDD:206637
Cadherin_repeat 129..229 CDD:206637 0/2 (0%)
Cadherin_repeat 238..328 CDD:206637 20/89 (22%)
Cadherin_repeat 459..532 CDD:206637 23/76 (30%)
Cadherin_repeat 546..637 CDD:206637 25/110 (23%)
Cadherin_repeat 645..733 CDD:206637 25/99 (25%)
Cadherin_repeat 746..833 CDD:206637 31/92 (34%)
Cadherin_repeat 843..938 CDD:206637 25/102 (25%)
Cadherin_repeat 947..1041 CDD:206637 29/105 (28%)
Cadherin_repeat 1051..1136 CDD:206637 22/103 (21%)
Cadherin_repeat 1337..1426 CDD:206637 19/93 (20%)
Cadherin_repeat 1445..>1515 CDD:206637 16/85 (19%)
Cadherin_repeat 1638..1723 CDD:206637 15/71 (21%)
Cadherin_repeat 1734..1817 CDD:206637
Cadherin_repeat 1836..1923 CDD:206637
Cadherin_repeat 1934..2025 CDD:206637
Cadherin_repeat 2034..2120 CDD:206637
Cadherin_repeat 2135..2226 CDD:206637
Cadherin_repeat 2235..2330 CDD:206637
Cadherin_repeat 2345..2437 CDD:206637
Cadherin_repeat 2446..2534 CDD:206637
Blue background indicates that the domain is not in the aligned region.

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