DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and cdh-9

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_510685.2	Gene:	cdh-9 / 186608	WormBaseID:	WBGene00000401	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	853	Identity:	177/853 - (20%)
Similarity:	283/853 - (33%)	Gaps:	323/853 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LGRRLIPARLLLGVIVAISLLSPALALHSPPDKNFSG-DNRKPAFKNCAGYAPKVKEEQPENTYV 107
            |||.|    |||.::...|  :..|..:.......|. ::.||.  |..|..|...:...|....
Worm     5 LGRSL----LLLALLAQYS--NTCLLKNGMSSVYLSAFEDLKPG--NVIGTLPFESQTSKETDVE 61

  Fly   108 LTV----EAVDPDPDQVIRYSIVQSPFERPKFFINPSTGVIFTTHTFDRDEPIHEKFVFVTVQAT 168
            |.|    |.||                      :.|.:..:....|.||||.: .||..|....:
Worm    62 LRVVKGNELVD----------------------VKPGSHDLILKKTLDRDEGV-GKFEAVVECRS 103

  Fly   169 DNGLPPLD-DVCTFN----VTIEDINDNAPAFNKARYDESMSENAQPDAVVMT-ISASDFDD-GN 226
            .|    || |....|    ||::|||||||.|:.|.|...:.|......:|.| ..|:|.|. |.
Worm   104 SN----LDTDFSQLNISVFVTVKDINDNAPVFDSAEYFVDIKEELPTGTIVFTDFEATDNDQPGP 164

  Fly   227 NSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPDPPQDAQIEVRIRV 291
            ||.|:|.|:......:.:|                               |||
Worm   165 NSFVQYTIVAGPHSHFLEI-------------------------------PDP------------ 186

  Fly   292 VESSIKPPSFVNPIDTPIYLKENLKNFTHPIATLRAVSNMPDKPEVIFELNTGRTEQTNSKNTFV 356
                .||
Worm   187 ----FKP---------------------------------------------------------- 189

  Fly   357 FNQIGNEVTISLGKTLDYEAITDYTLTMIVRNTHE--LGTEHQIKIQVEDVNDNIP-----YYT- 413
                    .|::...::||.|..:::.:..|:..|  |.:...:.:.:.||||.:|     :||
Worm   190 --------VITIKDRINYEEIKKFSVEIEARDQGEPSLASTVPLHVTIVDVNDLLPRFKHSHYTA 246

  Fly   414 -EVKSGTILENEPPGTPVMQVRAFDMDGTSANNIVSF--ELADNREYFTIDPNTGNITALT---- 471
             ..|:| :|..||..     :.|.|.|..:|:.|.|.  ||:   |:|.|| |.|:|.::|
Worm   247 KSQKNG-VLVFEPEA-----ISAQDGDRLNASLIFSLSGELS---EHFAID-NDGSIRSITPNPP 301

  Fly   472 ---TF-----DREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYL 528
               ||     :||:.: .|...|.|....|||                         .||.:.|
Worm   302 QRATFFVTASEREDTE-RNSTAILSIRLQSSL-------------------------AFQHNTY- 339

  Fly   529 AERLLEDANTNTEVIEVKAEDEDNASQILYSIESGNVGDAFKIGLK--TGKITVNQKLDY-ETIT 590
            :..:.......:.||.|.|..|:| :.:.||:    :.|...:.:.  :|.:.:.:||:. ||
Worm   340 STTISPTTPIGSTVITVVANSENN-TPLTYSL----LADTNTVSIDEVSGNVVLRKKLEKPET-- 397

  Fly   591 EYELKVRAFDGIYDDYTTVVIKIEDVND-----NPPVF-KQDYSVTILEETTYDDCILTVEAYDP 649
               |.|.|.||  ::..:..:.:...|.     :|..| |.:|.:||.:..     :|.|.
Worm   398 ---LNVTASDG--ENVVSTALHLMTANSEESCRSPIKFEKFEYKMTIGKLN-----VLGVV---- 448

  Fly   650 DIKDRNADQH----IVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGH---KNWQVLIKANDED 707
                 ||...    |.| |..|..|.:.||.:|.::|:       |...   |..::::.|..
Worm   449 -----NATSRTGTKITY-ILMNMNNDFEIDTNGVVKLL-------PKARLQCKVCELIVVAKS-- 498

  Fly   708 GVGTTVSTVKEVTVTLKDIN-DNAPFLINEMPVY--------------------------WQENR 745
              ||.::..|        || ||..|:::.....                          |:...
Worm   499 --GTQMAITK--------INVDNPAFVLHSTTALTLLILIILCLIFTMLAILVCRKFCEKWKTGH 553

  Fly   746 NPGHVVQLQANDYDDTPGAGNFTFGID-SEATPDIKTKFSMDGD---YLHANVQFDREAQKEYFI 806
            ....:..|  |...||        ||. :..||:..|::.::.|   ...:.....:.:|..:.:
Worm   554 RRSSICWL--NGTTDT--------GISITTTTPNTTTRYVVNSDRDRCYESKSPGPKRSQGAHLV 608

  Fly   807 PIRISDSG 814
            |:.::..|
Worm   609 PVTVTSDG 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637	26/106 (25%)
		Cadherin_repeat	200..292	CDD:206637	17/93 (18%)
		CA	332..410	CDD:214520	11/79 (14%)
		Cadherin_repeat	417..518	CDD:206637	30/114 (26%)
		Cadherin_repeat	531..619	CDD:206637	20/95 (21%)
		Cadherin_repeat	627..729	CDD:206637	24/109 (22%)
		Cadherin_repeat	736..834	CDD:206637	14/109 (13%)
		LamG	1127..1294	CDD:238058
		Cadherin_C	1358..1489	CDD:279398
cdh-9	NP_510685.2	E_set	<80..129	CDD:298831	20/53 (38%)
		Cadherin_repeat	135..234	CDD:206637	28/211 (13%)
		Cadherin_repeat	338..>405	CDD:206637	18/77 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165466
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930