DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and DSG1

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_001933.2	Gene:	DSG1 / 1828	HGNCID:	3048	Length:	1049	Species:	Homo sapiens

Alignment Length:	1185	Identity:	225/1185 - (18%)
Similarity:	351/1185 - (29%)	Gaps:	509/1185 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 QIKIQVEDVNDNIPYYTEVKSGTIL---------------------ENEPPGTPVMQVRAFDMDG 440
            :.:|||.|.|        .|:|||.                     |:.....|:.::.:    .
Human    24 EFRIQVRDYN--------TKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHS----D 76

  Fly   441 TSANNIVSFELA----DNREY--FTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNG 499
            .:||..|::.::    |...|  |.|:..||.|...:..|||...|:.:...|       |...|
Human    77 CAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRA-------LNSMG 134

  Fly   500 EPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDEDNA----SQILYSI 560
            :........|:.:.|.||:.|.|....: |.::.|::|.||.|:.:.|.|.|..    |:|.:.|
Human   135 QDLERPLELRVRVLDINDNPPVFSMATF-AGQIEENSNANTLVMILNATDADEPNNLNSKIAFKI 198

  Fly   561 ESGNVGDA--FKIGLKTGKI-TVNQKLDYETITEYELKVRAF--DGIYDDYTTVV---IKIEDVN 617
            ......|:  |.|...||:| |:|..||.|...:|.|.||..  ||..|..:...   |||.|||
Human   199 IRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVN 263

  Fly   618 DNPPVFKQDYSVTILEETTYDDCILTVEAYDPDIKDRNADQHIVYSIHQNDGNRWTID-----NS 677
            ||.|..:|......::|.|.:..:|.:...|.|.:.......:::.|..|:||.:.|:     |.
Human   264 DNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNV 328

  Fly   678 GCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQ 742
            |.|::||.||      ::..|.|
Human   329 GILKVVKPLD------YEAMQSL------------------------------------------ 345

  Fly   743 ENRNPGHVVQLQANDYDDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIP 807
                                   ..:.|:.::|                   :|......:|
Human   346 -----------------------QLSIGVRNKA-------------------EFHHSIMSQY--- 365

  Fly   808 IRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETD-IGRVFVDDLDDWDLE 871
             ::..|.:    :|::|:::.|.|    ...||.   .|...|.....| :|.....|||..
Human   366 -KLKASAI----SVTVLNVIEGPV----FRPGSK---TYVVTGNMGSNDKVGDFVATDLDTG--- 415

  Fly   872 DKYFEWKDLPHDQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPE 936
                            .|||                                  .|..|:...|.
Human   416 ----------------RPST----------------------------------TVRYVMGNNPA 430

  Fly   937 E--AVD-KSGSIRFIN-VTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVS---------- 987
            :  ||| ::|.:...| ||||::..:...:|. ..||:.|.||.:.....|.::.
Human   431 DLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQG-TILSIDDNLQRTCTGTININIQSFGNDDRTNT 494

  Fly   988 --NVDVFTVLQNENHTLDVRF-----SAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDE 1045
              |..:.|....:..|....:     |...|..|:.|..||
Human   495 EPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNG------------------------ 535

  Fly  1046 CLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMRRCLNGGSPR--YGE 1108
                   .::..::.:|.......:.......:|:..|:...|.|          ||:||  .|.
Human   536 -------AKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDC----------GGAPRSAAGF 583

  Fly  1109 NDVCDCIDG------FTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGP 1167
            ..|.:|.||      ..||..|                         ..:||..|.|     :.|
Human   584 EPVPECSDGAIHSWAVEGPQPE-------------------------PRDITTVIPQ-----IPP 618

  Fly  1168 LNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSIEMTVDN 1232
            .|.|.:..|        ||. .|.|.:||...::
Human   619 DNANIIECI--------DNS-GVYTNEYGGREMQ------------------------------- 643

  Fly  1233 CRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQT 1297
                                     .|||        |.::.        ||       .:.|..
Human   644 -------------------------DLGG--------GERMT--------GF-------ELTEGV 660

  Fly  1298 YNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQKNGWHEKDI 1362
            ...|||.:       ||:     :|..:.||
Human   661 KTSGMPEI-------CQE-----YSGTLRRN---------------------------------- 679

  Fly  1363 DDIRETIINYEDEGGGERDTDYDLNVLRTQPFYEEKLYKDPHALQGNMRDPNDIPDIADFLGDKK 1427
             .:||.     .|||        ||:...:.::.:|.|
Human   680 -SMREC-----REGG--------LNMNFMESYFCQKAY--------------------------- 703

  Fly  1428 ENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDG-DLNFDYLSNFGPRFRKLADM-YGE 1490
            ...|.|.|..:.|.:..|..||.|:..|   |:..|:..| ||:..:|...||:|:||||: .|:
Human   704 AYADEDEGRPSNDCLLIYDIEGVGSPAG---SVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGK 765

  Fly  1491 EPSDTDSNVDDDQGW 1505
            |     |..|.|..|
Human   766 E-----SYPDLDPSW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	5/12 (42%)
		Cadherin_repeat	417..518	CDD:206637	25/127 (20%)
		Cadherin_repeat	531..619	CDD:206637	35/99 (35%)
		Cadherin_repeat	627..729	CDD:206637	19/106 (18%)
		Cadherin_repeat	736..834	CDD:206637	9/97 (9%)
		LamG	1127..1294	CDD:238058	20/166 (12%)
		Cadherin_C	1358..1489	CDD:279398	31/132 (23%)
DSG1	NP_001933.2	Cadherin	54..148	CDD:278457	20/104 (19%)
		Cadherin_repeat	161..265	CDD:206637	36/104 (35%)
		Cadherin_repeat	273..379	CDD:206637	26/203 (13%)
		Cadherin_repeat	397..484	CDD:206637	27/140 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..534		7/48 (15%)
		Cadherin_C	646..761	CDD:279398	44/227 (19%)
		Desmoglein repeat 1	813..839
		Desmoglein repeat 2	840..869
		Desmoglein repeat 3	870..899
		Desmoglein repeat 4	900..927
		Desmoglein repeat 5	928..956
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1014..1035
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000