DRSC/TRiP Functional Genomics Resources

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Protein Alignment shg and hmr-1

DIOPT Version :9

Sequence 1:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster
Sequence 2:NP_001021650.1 Gene:hmr-1 / 173007 WormBaseID:WBGene00001980 Length:2920 Species:Caenorhabditis elegans


Alignment Length:1709 Identity:443/1709 - (25%)
Similarity:685/1709 - (40%) Gaps:499/1709 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 ARLLLGVIVAISLLSPALALHSPPDKNFSGDNRKPAFKNCAGYAPKVKEEQPENTY------VLT 109
            |.||:|:                .|.|    |.||.|.:||.|:...|  ..|.||      ::.
 Worm   849 ATLLIGI----------------EDVN----NNKPEFPDCAKYSDIAK--IMEGTYKTDPPTIVK 891

  Fly   110 VEAVDPD--PDQVIRYSIVQSPFERPKFFI--------NPSTGVIFTTHTFDRDEPIHEKFVFVT 164
            |||.|.|  .:..|.||:..:..|..|.|:        .||..|:|...|..|::        ||
 Worm   892 VEATDDDSSANGDIVYSLYYTQSESRKAFVIDRQTGVLTPSPHVVFDRETRPRED--------VT 948

  Fly   165 VQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDDGNNSL 229
            |:|||.|..||...|.|:|.:.|||||:|.|.:..|:.|:|........|:|:.|.|.|..:|:.
 Worm   949 VKATDRGDRPLIGFCQFSVEVVDINDNSPQFERPSYETSVSRFEAVGTSVITVFAFDNDAAHNAE 1013

  Fly   230 VEYEI--------LRERDFQYFK-IDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPDPPQDAQI 285
            :.|.:        ..:.|..:|: :::.||.|.|.:||..:..:....::...|.:|:..| :..
 Worm  1014 ITYSLEIDTTAGEEHQNDLDFFELVNRRSGEITLIKPIPMKTQKFIFNVIADDNGIPEALQ-SSA 1077

  Fly   286 EVRIRVVESSIKPPSF-VNPIDTP-IYLKENLKNFTHPIATLRAVSNMPDK-PEVIFELNTGRTE 347
            :|.:.|::...|.|.: .:|...| |.:.||:: ....|...||||:...: .:||::|......
 Worm  1078 QVTLNVLDKQQKAPKWQTSPDCKPGITVDENVE-LNKVILRCRAVSSGDSRNSDVIYKLTASGGP 1141

  Fly   348 QTNSKNTF-VFNQI--GNE-VTISLGKTLDYEAITDYTLTMIVRN-THELGTEHQIKIQVEDVND 407
            ...:::.| .||:.  ||| |.:.:.:.||||.:.:||||:...: |..:.:.....::|.||||
 Worm  1142 GNKAESKFRQFNKFENGNEWVEVVIMEGLDYEQVNNYTLTLTATDMTSRVASTKTFVVEVRDVND 1206

  Fly   408 NIPYYT-EVKSGTILENEPP--------GTPVMQVRAFDMDGTSANNIVSFEL-----ADNREYF 458
            .:|.:| ::.:|||.|...|        |.|::.|:|.|.|.....|.|.:.:     .:..::|
 Worm  1207 VVPQFTVDLFTGTIDEEMTPNEHLEKTNGKPIVTVKAIDTDSDGPQNEVHYRIVGEANGEETKHF 1271

  Fly   459 TIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQ 523
            .||..||.|.....||||:.|.|.:.|.|||.|.|:|.....||:.:...:|.|.|.||:.|.|:
 Worm  1272 RIDELTGEIFPNEKFDREKIDMYILTVEASDRSVSALPGANGPNKDNVKVQIVINDVNDNAPSFE 1336

  Fly   524 QDKYLAERLLEDANTNTEVIEVKAEDEDNASQILYSIESGNVGDAFKIGLKT--GKITVNQKLDY 586
            :.||:. |:.|......:||.:||.|.|..|.:.|.: .|..|.....|::|  |.|.|.:.||:
 Worm  1337 EQKYIG-RVKESEGEGHDVITIKAHDLDKHSNLRYHL-IGAGGGRIPFGVRTDSGTIFVKEPLDF 1399

  Fly   587 ETITEYELKVRAFDGIYDDYTTVVIKIEDVNDNPPVFKQD-YSVTILEE-TTYDDCILTVEAYDP 649
            |...:|.|.:.|.||.::..|.|.|.|||||||.|.|:|. |:.|::|| ......:..|.|.|.
 Worm  1400 EASDQYHLVLIASDGRHNATTNVYIHIEDVNDNAPQFEQQKYATTVIEEDVDIPKVLFNVHATDA 1464

  Fly   650 DIKDRNADQHIVYSIH-QNDGNRWTIDN-SGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTT 712
            |..::::  .|||.:. |.....:.|.. ||.:.|||.||||||.|..:|..:::|.|:||.|  
 Worm  1465 DQDEKSS--RIVYRLEGQGADEVFRIGKYSGTIELVKALDRDPPAGVPSWNFVVQAIDDDGNG-- 1525

  Fly   713 VSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGH-----VVQLQANDYDD-TPGAGNFTFGI 771
            :....:|.|.::|||||:|.....:..|.:|||.|.|     .:.:||.|:|| |....|..:||
 Worm  1526 LVGYADVQVNVRDINDNSPIFPERLFGYIEENREPIHSDGVYFMDVQARDFDDPTTENANIEYGI 1590

  Fly   772 DSEATPDIKTKFSMDGD--YLHANVQFDRE--AQKEYFIPIRISDSGVP---------------- 816
            ......:.::.|.:|.:  .:.|....|||  :::|:.|.:|.:|.|||                
 Worm  1591 VRNKLINGESVFRIDQNTGKIFAMRSLDREISSEREFIIEVRANDRGVPSREGFANVTIKVTDMN 1655

  Fly   817 -------------------------------------------------------------RQSA 820
                                                                         :||:
 Worm  1656 DNAPFFEKTRYEGSVEETAPIGAAVMSFSAFDADEEAKDNVFTYQLSEESDYFYVTTDKDSKQSS 1720

  Fly   821 VSIL------------------------------------------------------------- 824
            |.:|                                                             
 Worm  1721 VGVLRVKQPLDYEDVTQRDGFHLGIRVSDGRHDAEAAVHVALVDRNDHAPHIHGATEHRVREDVP 1785

  Fly   825 ----------------------------------------------------------------- 824
                                                                             
 Worm  1786 RGTSIGRYTATDRDAGDTARFRINRQSDPKRQFTIDQDGTLRVAHTLDREDIAVYNLIIEAYDNS 1850

  Fly   825 ----------------------------------------------------------------- 824
                                                                             
 Worm  1851 NNIGRQMVAVYLQDVNDNGPEPYTVPRPCIFRENTPVNQLGTCEIRATDRDTAEFGPPFTMEVSP 1915

  Fly   825 ------------------------------------------------------------HLVIG 829
                                                                        |::||
 Worm  1916 SFKYSQYLNVIFNANGDGGNGSMTITPLQEFDREAPVPGKILEIPLILADRAGRRNEASVHVIIG 1980

  Fly   830 DVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMI 894
            |:|||.|.:|...|.:.:|.|...||.||||:|||.|||||.||.|.||| ....|.|: ..|.|
 Worm  1981 DLNDNTMHDGRMTIHVNSYLGRLKETVIGRVYVDDADDWDLGDKTFSWKD-SRPGFELS-DKGSI 2043

  Fly   895 TMLVHTAEGEYDLSFVVTEDSMFVPRHSVDA--YVTVVVRELPEEAVDKSGSIRFINVTKEEFIS 957
            ||....|.|.|.:|..|.:::     ...||  ||||:|..:|:.|.|..||::.: :.:|..:.
 Worm  2044 TMAGEMAAGTYTMSANVHDNA-----RDEDAVGYVTVIVNAVPQIAFDNQGSVQLL-IAEETPLQ 2102

  Fly   958 VPRDFQSPDA--LSLKDRLQLSLAKLFNTSVSNVDVFTV------LQNEN-HTLDVRFSAHGSPY 1013
            :|.||...|:  .||.|..:..:.......|: ||||:|      ||..: ..|:|||:|.||.|
 Worm  2103 LPDDFIRADSNGQSLMDTFKQEMTAYMGGDVT-VDVFSVQVGIATLQTRDVPVLNVRFNARGSTY 2166

  Fly  1014 YAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKF-KCEESCTNELHKSSVPY---MIYSNT 1074
            ....:|||::|.::..|:.:|:::::.|.||.|   || :|:..|..   .:|..|   ::.:|:
 Worm  2167 RDTAQLNGLIAAHRADLQRKLNVEIVGVGIDMC---KFTQCDAGCQT---LNSADYDGIVVSANS 2225

  Fly  1075 TSFVGVNAFVQAQCVCEAPLMRR--------CLNGG-----SPRYGENDVCDC-IDGFTGPHCEL 1125
            |..|||||..:..|.|  |:.|.        |.|.|     :|.:    .|:| .||..|..|:.
 Worm  2226 TVIVGVNATSRDDCTC--PVWRAPPACQHSLCHNDGVCHNTNPGF----FCECRNDGLKGARCQG 2284

  Fly  1126 VSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNF---NPLLAISDFLALELDNG 1187
            .:.:|.|:|:|:|:|:.||.:..||..........|:.|.|||..   :..:..||::.::|..|
 Worm  2285 TTRSFGGNGFAWYKPMPACTSLNISFSFMTTQSDALLFYNGPLETLRNDTHIEYSDYIFIQLRGG 2349

  Fly  1188 YPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTS--IEMTVDNCRL-------STCQT-LG 1242
            ...|.|.....:..........:.|.|:. ||.:.:..  :|:.|||||.       |:|:. |.
 Worm  2350 RISLEVSMNGQSRSSLEVASTALNDGTWH-DISVNQEGKRVELVVDNCRFLGAGADDSSCRAELY 2413

  Fly  1243 APIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFR 1307
            .| ..:|.||:..|:|:||    |..|..| ::.....:.|..||:|||.:|...|:|..|:..:
 Worm  2414 TP-DDDERLNIVTPVQIGG----LAPLSGQ-DYPQTIPRAGLNGCVRNLNVNGDQYDLATPAFEQ 2472

  Fly  1308 NIDSGCQQSVAVAFSFGID 1326
            |.:.||:...|...|..:|
 Worm  2473 NSEKGCRLWGATCDSNSVD 2491

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637 37/113 (33%)
Cadherin_repeat 200..292 CDD:206637 22/100 (22%)
CA 332..410 CDD:214520 24/83 (29%)
Cadherin_repeat 417..518 CDD:206637 38/113 (34%)
Cadherin_repeat 531..619 CDD:206637 33/89 (37%)
Cadherin_repeat 627..729 CDD:206637 36/104 (35%)
Cadherin_repeat 736..834 CDD:206637 37/435 (9%)
LamG 1127..1294 CDD:238058 51/179 (28%)
Cadherin_C 1358..1489 CDD:279398
hmr-1NP_001021650.1 Cadherin_repeat 431..521 CDD:206637
Cadherin_repeat 534..638 CDD:206637
Cadherin_repeat 647..742 CDD:206637
Cadherin_repeat 752..861 CDD:206637 6/31 (19%)
Cadherin_repeat 875..975 CDD:206637 36/109 (33%)
Cadherin_repeat 983..1085 CDD:206637 23/102 (23%)
Cadherin_repeat 1103..1206 CDD:206637 30/103 (29%)
Cadherin_repeat 1216..1331 CDD:206637 38/114 (33%)
Cadherin_repeat 1340..1432 CDD:206637 34/93 (37%)
Cadherin_repeat 1443..1542 CDD:206637 35/102 (34%)
Cadherin_repeat 1553..1657 CDD:206637 28/103 (27%)
Cadherin_repeat 1666..1768 CDD:206637 4/101 (4%)
Cadherin_repeat 1779..1868 CDD:206637 0/88 (0%)
EGF_CA 2250..2283 CDD:238011 9/36 (25%)
LamG 2286..2459 CDD:238058 51/179 (28%)
LamG 2533..2679 CDD:304605
Cadherin_C 2812..>2919 CDD:279398
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 187 1.000 Domainoid score I1975
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4879at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.920

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