DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shg and Fat1

DIOPT Version :9

Sequence 1:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster
Sequence 2:XP_006509330.1 Gene:Fat1 / 14107 MGIID:109168 Length:4645 Species:Mus musculus


Alignment Length:1664 Identity:385/1664 - (23%)
Similarity:618/1664 - (37%) Gaps:505/1664 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 GVIVAISL----LSPALALH-SPPDKNF-----------SGDNRKPAFKNCAGYAPKVKEEQPEN 104
            |:|...:|    |.|..:|: |..|..|           .|:...|.|.. ..|..::.|..|.:
Mouse  2470 GIITLSNLRRHTLKPFYSLNVSVSDGVFRSSARVNVTVMGGNLHSPVFHQ-NEYEVELAENAPLH 2533

  Fly   105 TYVLTVEAVDPDPD--QVIRYSIVQSPFERPKFFINPSTGVIFTTHTFDRDEPIHEKFVFVTVQA 167
            |.|:.|:|.|.|..  ..:.|.|| :.|.:.:|::| ..|.|||....||:.|. ||.:.:.:.|
Mouse  2534 TLVVQVKASDRDSGIYSHVTYHIV-NDFAKDRFYVN-DRGQIFTLEKLDRETPA-EKVISIRLMA 2595

  Fly   168 TDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDDGNNSLVEY 232
            .|.|....  .||.||.:.|.|||||.|...:|:.::..:|.....|:.:.|||.|:|:|:.|.|
Mouse  2596 KDAGGKVA--FCTVNVILTDDNDNAPQFRSTKYEVNIGSSAAKGTSVVKVFASDADEGSNADVTY 2658

  Fly   233 EILRERDFQYFK----IDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPDPPQDAQIEVRIRVVE 293
            .|  |.|.:..|    |:|.:|:|..|..:.....:.:...|||.: ...||:::.:.|.|:::.
Mouse  2659 AI--EADSESVKENLEINKLTGLITTKESLIGLENEFFTFFVRAVD-SGSPPRESVVPVYIKILP 2720

  Fly   294 SSIKPPSFVNPI-------DTPIYLKENLKNFTHPIATLRAVSNMPDKPEVIFELNTGRTEQTNS 351
            ..::.|.|..|.       ||||..:.:|....|..|             |::.|..|.|.::|.
Mouse  2721 PEVQLPRFSEPFYTYTISEDTPIGTEIDLIRVEHGGA-------------VLYILVKGNTPESNR 2772

  Fly   352 KNTFVFNQIGNEVTISLGKTLDYEAITDYTLTMIVRNT--------------------------- 389
            ...||.::....  :.|.|:||:|....|..:::.|.|                           
Mouse  2773 DEFFVIDRQNGR--LKLEKSLDHETTKWYQFSILARCTLDDYEVVASIDVSIQVKDANDNSPVLE 2835

  Fly   390 ----------------------------------------------------------------- 389
                                                                             
Mouse  2836 SSPYEAFIVENLPGGSRVIQIRASDLDSGANGQVMYSLDQSQDADIIESFAINMETGWITTLKEL 2900

  Fly   390 -HELGTEHQIK-------------------IQVEDVNDNIPYYT-EVKSGTILENEPPG------ 427
             ||....:|||                   :.|.||||:.|.:| |:..||:.|::|||      
Mouse  2901 DHEERASYQIKVVASDHGEKVQLSSTAIVGVTVTDVNDSPPRFTAEIYKGTVSEDDPPGGVIAIL 2965

  Fly   428 ----------------------------------------------------------------- 427
                                                                             
Mouse  2966 STTDADTEEINRQVSYFITGGDALGQFAVENVQSDWRVYVKKPLDREQKDSYLLTVTATDGTFSS 3030

  Fly   428 --------------TP--------------------VMQVRAFDMDGTSANNIVSFELADNREYF 458
                          :|                    ||||.|.|.|..|...|.........|.|
Mouse  3031 KARVEVKVLDANDNSPVCEKTSYSDTIPEDALPGKLVMQVSATDADIRSNAEITYTLFGSGAEKF 3095

  Fly   459 TIDPNTGNITALTTFDREERDFYNVKVIA-------------------SDNSPS--------SLF 496
            .::|:||.:..|...||||:..||:.|.|                   :||:|.        ::|
Mouse  3096 KLNPDTGELRTLALLDREEQAVYNLLVKATDGGGRSCQAAIVLTLEDVNDNAPEFTAEPYTITVF 3160

  Fly   497 DNGEP----------------NR------------------------------------------ 503
            :|.||                ||                                          
Mouse  3161 ENTEPGTPLTRVQATDADTGLNRKISYSLVESADGQFSINERSGIIQLEKHLDRELQAVYTLTLK 3225

  Fly   504 -------------GHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDED---N 552
                         |..|  :|:.|.||:.|.|:..:|.|. :.||....|||::|.|...|   |
Mouse  3226 AVDQGLPRRLTATGTVV--VSVLDINDNPPVFEYREYGAS-VSEDIVIGTEVLQVYAASRDIEAN 3287

  Fly   553 ASQILYSIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFDG---IYDDYTTVVIKIE 614
            | :|.|:|.|||....|.|..|||.|.:.:.||||:..||.|.|.|.||   ...|..||.|.:.
Mouse  3288 A-EITYAIISGNEHGKFSIDSKTGAIFIIESLDYESSHEYYLTVEATDGGTPSLSDVATVNINVT 3351

  Fly   615 DVNDNPPVFKQD-YSVTILEETTYDDCILTVEAYDPDIKDRNADQHIVYSIHQ-NDGNRWTIDN- 676
            |:|||.|||.|| |:..:.|:...:..::|:.|   |..|..::.||.|||.: |.|:.:|||. 
Mouse  3352 DINDNSPVFSQDTYTTVVSEDAALEQPVITIMA---DDADGPSNSHIHYSIIEGNQGSPFTIDPV 3413

  Fly   677 SGCLRLVKTLDRDPPNGHKNWQVLIKANDEDG---VGTTVSTVKEVTVTLKDINDNAP-FLINEM 737
            .|.:::.|.|||:..:|   :.:.::|.|...   |.||.     |.:.:.|:||||| |..:..
Mouse  3414 RGEVKVTKPLDRETISG---YTLTVQAADNGNPPRVNTTT-----VNIDVSDVNDNAPLFSRDNY 3470

  Fly   738 PVYWQENRNPG-HVVQLQANDYDDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQ 801
            .|..|||:..| .|::|...|.|.:.....|.|.|.| ...:...:.:..|..|.| ....|:.:
Mouse  3471 SVIIQENKPVGFSVLKLVVTDKDSSHNGPPFFFTIVS-GNDENAFEVNQHGVLLTA-ATIKRKVK 3533

  Fly   802 KEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEG--SSRIFIYNYKGEAPETDIGRVFVDD 864
            ..|.:.::::|||.|:.|  |:.|:.|..:.::.....  ...|||..:..|.....||::...|
Mouse  3534 DHYLLHVKVADSGKPQLS--SMTHIDIRVIEESIHPPAILPLEIFITAFGEEYSGGVIGKIHATD 3596

  Fly   865 LDDWD-----LEDKYFEWKDLPH--DQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHS 922
            .|.:|     |:         ||  ..|.::.:.|.:........|:|.|:..||:.     :.:
Mouse  3597 QDVYDTLMYSLD---------PHMDGLFSVSSTGGKLIAHRKLDIGQYLLNVSVTDG-----KFT 3647

  Fly   923 VDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFI-SVPRDFQSPDALSLKDRLQLSLAKLFNTSV 986
            ..|.:||.::::.:|.::.:.:|||.|:|.|||: ...|:||.            :|..:.....
Mouse  3648 TVADITVHIQQVTQEMLNHTVAIRFANLTPEEFVGDYWRNFQR------------ALRNILGVRK 3700

  Fly   987 SNVDVFTVLQNENHT-LDVRF------SAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNID 1044
            :::.:.::..:|.|: |||..      ..|.|......|:|..|..    :|..:.:::|.|...
Mouse  3701 NDIQIVSLQPSEPHSHLDVLLFVERSGGTHVSTKQLLHKINSSVTD----VEEIIGVRILEVFQK 3761

  Fly  1045 ECL-IE---KFKCEESCTNELHKSSVPYMIYSNTT----SFVGVNAFVQAQCVCE----APLMRR 1097
            .|. ::   || |:|       |.||...:.|..:    |||.......|.|:|:    .|:...
Mouse  3762 LCAGLDCPWKF-CDE-------KVSVDENVMSTHSTARLSFVTPRHHRTAVCLCKDGTCPPVHHG 3818

  Fly  1098 CLN----GGS-----PRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACN--NTKISL 1151
            |.:    .||     || .|...|.|..|..|......|:.|.|:.:..|..:...|  ..|:|:
Mouse  3819 CEDNPCPAGSECVADPR-EEKYSCVCPGGGFGKCPGSSSITFTGNSFVKYRLLENENRLEMKLSM 3882

  Fly  1152 EITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQ 1216
            .:.......::||...         :|:..||:..|......|.|||...:..|.|::...:.:.
Mouse  3883 RLRTYSSHAVVMYARG---------TDYSILEIHTGRLQYKFDCGSGPGIVSVQSIQVNDGQWHA 3938

  Fly  1217 LDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQ 1281
            :.:.::....::.:|....::    |...|..:.||::..:..||   .|.|.|.: :.......
Mouse  3939 VSLEVEGNYAKLVLDEVHTAS----GTAPGALKTLNLDNYVFFGG---HLRQQGTK-HGRGAQVA 3995

  Fly  1282 KGFFGCIRNLTINEQTYNL-GMPSVFRNIDS------GC 1313
            .||.||:.::.:|.|...| ..|..:.:|:.      ||
Mouse  3996 SGFRGCMDSIYLNGQELPLNNKPRAYAHIEEWVDLSHGC 4034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637 33/99 (33%)
Cadherin_repeat 200..292 CDD:206637 27/95 (28%)
CA 332..410 CDD:214520 25/189 (13%)
Cadherin_repeat 417..518 CDD:206637 44/303 (15%)
Cadherin_repeat 531..619 CDD:206637 39/93 (42%)
Cadherin_repeat 627..729 CDD:206637 30/106 (28%)
Cadherin_repeat 736..834 CDD:206637 26/98 (27%)
LamG 1127..1294 CDD:238058 33/168 (20%)
Cadherin_C 1358..1489 CDD:279398
Fat1XP_006509330.1 Cadherin_repeat 39..145 CDD:206637
Cadherin_repeat 154..253 CDD:206637
Cadherin 278..357 CDD:421759
Cadherin_repeat 372..460 CDD:206637
Cadherin_repeat 468..566 CDD:206637
Cadherin_repeat 576..663 CDD:206637
Cadherin_repeat 725..819 CDD:206637
Cadherin_repeat 827..924 CDD:206637
Cadherin_repeat 933..1017 CDD:206637
Cadherin_repeat 1044..1136 CDD:206637
Cadherin_repeat 1144..1242 CDD:206637
Cadherin_repeat 1251..1346 CDD:206637
Cadherin_repeat 1364..1477 CDD:206637
Cadherin_repeat 1486..1583 CDD:206637
Cadherin_repeat 1591..1687 CDD:206637
Cadherin_repeat 1696..1786 CDD:206637
Cadherin_repeat 1794..1899 CDD:206637
Cadherin_repeat 1909..1995 CDD:206637
Cadherin_repeat 2009..2102 CDD:206637
Cadherin_repeat 2110..2199 CDD:206637
Cadherin_repeat 2212..2304 CDD:206637
Cadherin_repeat 2312..2395 CDD:206637
Cadherin_repeat 2419..2513 CDD:206637 10/42 (24%)
Cadherin_repeat 2521..2617 CDD:206637 33/100 (33%)
Cadherin_repeat 2626..2719 CDD:206637 27/95 (28%)
Cadherin_repeat 2733..2830 CDD:206637 22/111 (20%)
Cadherin_repeat 2838..2938 CDD:206637 8/99 (8%)
Cadherin_repeat 2947..3044 CDD:206637 6/96 (6%)
Cadherin_repeat 3052..3146 CDD:206637 23/93 (25%)
Cadherin_repeat 3154..3251 CDD:206637 11/98 (11%)
Cadherin_repeat 3259..3356 CDD:206637 41/98 (42%)
Cadherin_repeat 3364..3461 CDD:206637 30/107 (28%)
Cadherin_repeat 3470..3561 CDD:206637 26/94 (28%)
Cadherin_repeat 3586..3659 CDD:206637 18/86 (21%)
LamG 3879..4010 CDD:214598 29/147 (20%)
EGF_CA 4041..4075 CDD:238011
EGF_CA 4078..4113 CDD:238011
EGF 4118..4148 CDD:394967
EGF_CA 4152..4188 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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