DRSC/TRiP Functional Genomics Resources

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Protein Alignment shg and Dsg1a

DIOPT Version :9

Sequence 1:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster
Sequence 2:NP_034209.2 Gene:Dsg1a / 13510 MGIID:94930 Length:1057 Species:Mus musculus


Alignment Length:1223 Identity:243/1223 - (19%)
Similarity:368/1223 - (30%) Gaps:517/1223 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   372 LDYEA--ITDYTLTMIVRNTHELGTEHQIKIQVEDVNDNIPYYTEVKSGTIL------------- 421
            :|:.:  |....||.:|  ..|:.:|.|  |||.|.|        .|:|||.             
Mouse     1 MDWHSFRIAALLLTSLV--VLEVNSEFQ--IQVRDHN--------AKNGTIKWHSIRRQKREWIK 53

  Fly   422 --------ENEPPGTPVMQVRAFDMDGTSANNIVSFELA----DNREY--FTIDPNTGNITALTT 472
                    |:.....|:.::.:    ..:||..|::.::    |...|  |.|:..||.|...:.
Mouse    54 FAAACREGEDNSKRNPIAKIHS----DCAANQPVTYRISGVGIDQPPYGIFIINQKTGEINITSI 114

  Fly   473 FDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDAN 537
            .|||...|:.:...|       |...|:........|:.:.|.||:.|.|....:|.: :.|::|
Mouse   115 VDREVTPFFIIYCRA-------LNAQGQDLENPLELRVRVMDINDNPPVFSMTTFLGQ-IEENSN 171

  Fly   538 TNTEVIEVKAEDEDNA----SQILYSIESGNVGDA--FKIGLKTGKI-TVNQKLDYETITEYELK 595
            .||.|:::.|.|.|..    |.|.:.|......|:  |.|..|||:| |:|..||.|..::|.|.
Mouse   172 ANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEIRTMNNFLDREQYSQYSLV 236

  Fly   596 VRAF--DGIYDDYTT---VVIKIEDVNDNPPVFKQ-DYSVTILEETTYDDCILTVEAYDPDIKDR 654
            ||..  ||..|..:.   ..|.|.|||||.|..:| .|.:|| ||......::.:...|.|.:..
Mouse   237 VRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDITI-EENALHSQLVQIRVIDLDEEFS 300

  Fly   655 NADQHIVYSIHQNDGNRWTID-----NSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVS 714
            :..:.|::.|..|:||.:.|:     |.|.|::||.||.:   ..||.|:.|      ||.....
Mouse   301 DNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDYE---AMKNLQLSI------GVRNVAE 356

  Fly   715 -----------TVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYDDTPGAGNFT 768
                       |...||||:.::.:.:.|             .|                 |:.|
Mouse   357 FHQSIISQYRLTATMVTVTVLNVIEGSVF-------------RP-----------------GSKT 391

  Fly   769 FGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVND 833
            |.:||.               :.||                               |.|      
Mouse   392 FVVDSR---------------MEAN-------------------------------HRV------ 404

  Fly   834 NAMSEGSSRIFIYNYKGE--APETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITM 896
                            ||  |.:.|.||...         :..:|..:.|.:...::..||:||:
Mouse   405 ----------------GEFVATDLDTGRAST---------NVRYEMGNNPENLLVVDSRTGIITL 444

  Fly   897 LVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRD 961
                                   |:                           .||.|::..:..:
Mouse   445 -----------------------RN---------------------------RVTMEQYQRLNGE 459

  Fly   962 FQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQN 1026
            ::. ..||:.|.||.:........:|.....|..::..       |:.||            ..:
Mouse   460 YKG-TVLSIDDSLQRTCTGTIVIELSGTGWVTGSESGG-------SSSGS------------GDD 504

  Fly  1027 QQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCE 1091
            :.|:.|.                                     |..|:|             .|
Mouse   505 RDRVTNG-------------------------------------YQGTSS-------------TE 519

  Fly  1092 APLMRRCLNGGSPRYGENDVCDCIDG-------FTGPHCELVSVAFYGSGYAFYEPIAACNNTKI 1149
            .|.......|||.          |||       |.|...|.:....||..               
Mouse   520 NPQRVTGSWGGSG----------IDGTRPNTNPFQGDPDETLETPLYGDN--------------- 559

  Fly  1150 SLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRT 1214
                         ::.||....  |.|..||.|.|   .|.|.:                     
Mouse   560 -------------VHFGPAGIG--LLIMGFLVLGL---VPFLLI--------------------- 585

  Fly  1215 YQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNW-THV 1278
                              |    |...|||.|           ..|..||.....|....| ...
Mouse   586 ------------------C----CDCGGAPGG-----------GAGFEPVPECSDGAIHTWAVEG 617

  Fly  1279 PNQKGFFG----CIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLAL 1339
            |..:...|    |:..:.       .|..:|...||:.           |:              
Mouse   618 PQPEPHEGITTICVPQMP-------PGNANVIEYIDNS-----------GV-------------- 650

  Fly  1340 LLIILLAVVVQKKQKNGWHEKDIDDIRETIINYEDEGGGERDTDYDL-NVLRTQPFYEEKLYKDP 1403
                         ..|.:..:::.|:          |||||.|.::| :.::|.        ..|
Mouse   651 -------------YTNEYCGREMQDL----------GGGERTTGFELMDGVKTS--------AAP 684

  Fly  1404 HALQ---GNMRDPNDIPDIAD-----------FLGDKKENCDRDVGATTVDDVRHYAYEGDGNSD 1454
            ...|   |.:| .|.:.:..|           |........|.|.|..:.|.:..|..||.|:..
Mouse   685 EICQEYSGTLR-RNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPA 748

  Fly  1455 GSLSSLASCTDDG-DLNFDYLSNFGPRFRKLADM-YGEEPSDTDSNVDDDQGW 1505
            |   |:..|:..| ||:..:|...||:|:||||: .|:|   .||..|.|..|
Mouse   749 G---SVGCCSFIGEDLDESFLDTLGPKFKKLADISLGKE---IDSYPDSDPSW 795

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637
Cadherin_repeat 200..292 CDD:206637
CA 332..410 CDD:214520 13/39 (33%)
Cadherin_repeat 417..518 CDD:206637 25/127 (20%)
Cadherin_repeat 531..619 CDD:206637 35/99 (35%)
Cadherin_repeat 627..729 CDD:206637 31/117 (26%)
Cadherin_repeat 736..834 CDD:206637 10/97 (10%)
LamG 1127..1294 CDD:238058 26/171 (15%)
Cadherin_C 1358..1489 CDD:279398 38/147 (26%)
Dsg1aNP_034209.2 CA 73..155 CDD:214520 21/92 (23%)
Cadherin_repeat 165..265 CDD:206637 35/100 (35%)
Cadherin_repeat 273..379 CDD:206637 31/115 (27%)
Cadherin_repeat 391..483 CDD:206637 29/219 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 490..552 20/140 (14%)
Cadherin_C 664..779 CDD:279398 36/126 (29%)
Desmoglein repeat 1 832..858
Desmoglein repeat 2 859..888
Desmoglein repeat 3 889..918
Desmoglein repeat 4 919..946
Desmoglein repeat 5 947..975
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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