Protein Alignment shg and LOC1270327

DIOPT Version :10

• Sequence 1: NP_476722.1
• Gene: shg / 37386
• FlyBaseID: FBgn0003391
• Length: 1507
• Species: Drosophila melanogaster
• Sequence 2: XP_061502466.1
• Gene: LOC1270327 / 1270327
• VectorBaseID: AGAMI1_000178
• Length: 1047
• Species: Anopheles gambiae
• Alignment Length: 1374
• Identity: 416/1374 - (30%)
• Similarity: 615/1374 - (44%)
• Gaps: 368/1374 - (26%)

  Fly    51 ARLLLGVIVAISLLSPALALHSPPDKNFSGD-NRKPAFKNCAGYAPKVKEEQPENTYVLTVEAVD 114
            ||.:..|::.||  |..:..|.....:|:.. |.||:|.||..|.|.:||||...|.||.|.|.|
Mosquito     2 ARQIGFVLLLIS--SNWIHCHCLAAADFNAPVNHKPSFHNCGEYKPTLKEEQEPGTSVLRVAATD 64

  Fly   115 PDPDQVIRYSIVQSPFERPKFFINPSTGVIFTTHTFDRDEPIHEKFVFVTVQATDNGLPPLDDVC 179
            ||..|.|:|||:....|...|.|:..||.||:.:.||||.|..:...::||:|||||.|.|||||
Mosquito    65 PDQSQTIKYSILNEMREERVFAIDEDTGEIFSAYIFDRDPPYRDTEFYITVRATDNGQPSLDDVC 129

  Fly   180 TFNVTIEDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDDGNNSLVEYEILRE-RDFQYF 243
            |..|||.|||||.|.|:|..|:..:|.|......|..|:|.|.|:..|::|.:||:.| :|..||
Mosquito   130 TIKVTILDINDNPPVFDKDFYEAFVSMNTTLRQQVTIITAKDIDEQTNNVVNFEIVEEYKDSSYF 194

  Fly   244 KIDKESGIIYLKRPIDKRPGQSYAIIVRAYN--VVPDPPQDAQIEVRIRVVESSIKPPSFVNPID 306
            :||:.:|::.|.:.||:.||:.||:.|||||  .:.:..::.:::|::.:::...:.|.|....:
Mosquito   195 EIDQHTGVLTLAKRIDRNPGEYYALRVRAYNQGYIENESENPEVDVKVHIIDDDKRLPYFTKVPE 259

  Fly   307 TPIYLKENLKNFTHPIATLRAVSNMPDKPEVIFELNTGRTEQTNSKNTFVFNQIGNEVTISLGKT 371
            .|:.|.||...|...:|...|.||..:...||||:..|:.|||||.:||:..||.:...|.|.:.
Mosquito   260 VPVILHENFTAFDQILAVFEANSNTNNDSNVIFEIVRGKFEQTNSLHTFLLEQINHTAHIKLARA 324

  Fly   372 LDYEAITDYTLTMIVRNTHELGTEHQIKIQVEDVNDNIPYYTEVKSGTILENE-PPGTPVMQVRA 435
            ||||.||:||:|:...|.|:|.||..:||.:.|||||:|...|..|  .||:| ...|||:|:.|
Mosquito   325 LDYERITEYTITVRATNRHDLATEAVVKIMILDVNDNVPLIVEAVS--YLEHELIDNTPVIQIHA 387

  Fly   436 FDMDGTSANNIVSFELAD-NREYFTIDPNTGNITALTTFDREERDFYNVKVIASDNSPSSLFDNG 499
            :|:||||||||:|:.:|: |:.:||||.:||.:|.....:.:|:|.|.:|::|.||:||:||.|.
Mosquito   388 YDLDGTSANNIISYSIAESNQLHFTIDSHTGTVTKQNRLNDDEKDIYFIKILAKDNAPSALFRNN 452

  Fly   500 EPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDEDNASQILYSIESGN 564
            :||            .:.|
Mosquito   453 KPN------------MSSH---------------------------------------------- 459

  Fly   565 VGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFDGIYDDYTTVVIKIEDVNDNPPVFKQDYSV 629
                                                       |:::||
Mosquito   460 -------------------------------------------TLIVKI---------------- 465

  Fly   630 TILEETTYDDCILTVEAYDPDIKDRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGH 694
                                    .|.|.:|:                            |.|..
Mosquito   466 ------------------------INRDLNII----------------------------PQNAI 478

  Fly   695 KNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYD 759
            .|                                          ::.||.|...
Mosquito   479 TN------------------------------------------IHGQEQRTSN----------- 490

  Fly   760 DTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSIL 824
                                             .:.|..        .:|||.|...|
Mosquito   491 ---------------------------------GISFQN--------ALRISKSYEER------- 507

  Fly   825 HLVIGDV-NDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLED---KYFEWKDL----P 881
                 || ||..       |.::||:|...:..||.|:.    |:|:||   |.|.|.:.    .
Mosquito   508 -----DVFNDRF-------IMVHNYEGTLTDKLIGSVYF----DYDIEDNSNKLFLWDERASTGT 556

  Fly   882 HDQFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIR 946
            ...|:||..:|||.||..|.||.|:|.|.|.|:|....||.|.|.|||.|:.:..:.|::|||||
Mosquito   557 RKHFKLNSKSGMIMMLKGTPEGIYNLEFTVIEESSDFSRHKVSARVTVTVKNISTKTVNQSGSIR 621

  Fly   947 FINVTKEEFIS-VPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHT----LDVRF 1006
            |.|||.|:||| ...:..:|     ..|||.|:|.:.:|:...||:||: .|...|    |||.|
Mosquito   622 FYNVTAEKFISQTLSELNTP-----MYRLQESIASILDTNPDKVDIFTI-NNRKLTRGAFLDVFF 680

  Fly  1007 SAHGSPYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIY 1071
            :...:.|.:.|.||.:::.:.::||.::..:::.|.||||:.:...|:::|.|.:|:|..|.:::
Mosquito   681 AVDDTIYTSSEVLNAVLSLHLRKLEEDVGYRIVSVGIDECIAKGHMCKQACKNRVHRSQKPIVVH 745

  Fly  1072 SNTTSFVGVNAFVQAQCV--CEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSG 1134
            :||:||||:...|||||:  .|:.|: .|||||:   .:|..|:|..||.||.||.:.:.|.|||
Mosquito   746 TNTSSFVGMTTLVQAQCIPQIESSLV-ACLNGGT---FQNGKCNCPMGFEGPQCEKLDICFDGSG 806

  Fly  1135 YAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGA 1199
            ||.|..|.:.|...||:.:.|:...||:.|:|||.::|.|....|||||:::|..||.:|||:|.
Mosquito   807 YAIYPLINSGNVNNISIGLLPRQKDGLVFYMGPLKYDPSLKTPPFLALEINDGMLVLLLDYGTGM 871

  Fly  1200 IRIRHQHIKMVADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNE------FLNVNAPLQ 1258
            ||..||  :::......:||:|:....|:...:.:|.     |:.....|      ||..|.|:.
Mosquito   872 IRFEHQ--QLILHTVTTVDIVLEPHRFEIHTASNKLK-----GSSRSRYENKDLRGFLPGNMPIL 929

  Fly  1259 LGGTPVDLEQLGRQLNW----THVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAV 1319
            |||| ::....|...||    ..:|....:.||:|.||||....:..:|.|..|:....|.|.:|
Mosquito   930 LGGT-INHFAKGLLYNWPLHLVGIPQTIDYDGCMRKLTINGHMIDFMLPIVENNVFFSSQWSNSV 993

  Fly  1320 AFSFGIDRNFIIAIIVCLALLLIILLAV-VVQKKQKNGWHEKDIDDIRETIINYEDEGGGERDTD 1383
            ..||.:   .|..:.:...|:|.|..:| .||.|.|              :.|           .
Mosquito   994 HKSFYL---MIFELGIVFFLMLAIFYSVKYVQTKLK--------------LCN-----------Q 1030

  Fly  1384 YDLNVLRTQ 1392
            |.:|.|.||
Mosquito  1031 YSMNELETQ 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637	51/97 (53%)
		Cadherin_repeat	200..292	CDD:206637	32/94 (34%)
		CA	332..410	CDD:214520	37/77 (48%)
		Cadherin_repeat	417..518	CDD:206637	42/102 (41%)
		Cadherin_repeat	531..619	CDD:206637	3/87 (3%)
		Cadherin_repeat	627..729	CDD:206637	6/101 (6%)
		Cadherin_repeat	736..834	CDD:206637	12/98 (12%)
		LamG	1127..1294	CDD:238058	60/176 (34%)
		CADH_Y-type_LIR	1430..1489	CDD:460041
LOC1270327	XP_061502466.1	None