DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Cdh9

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	XP_011243639.1	Gene:	Cdh9 / 12565	MGIID:	107433	Length:	867	Species:	Mus musculus

Alignment Length:	1203	Identity:	247/1203 - (20%)
Similarity:	372/1203 - (30%)	Gaps:	575/1203 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 NTFVFNQIGNEVTISLGKTLDYEAITDYTL--TMIVRNT-HELGTEHQIKIQVEDVNDNIPYYT- 413
            |.||.::  |...|...|.||.|..:.|.|  ..|.|.| .::..|.:..|::.|:|||.|.:|
Mouse   177 NLFVIDE--NTGDIHAAKRLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTK 239

  Fly   414 EVKSGTILENEPPGTPVMQVRAFDMD----GTSANNIVSFELADNREYFTIDPNTGNI-TALTTF 473
            ::.:.::.|....||.|:||.|.|.|    |.||.  |.:.:...:.||::||.:|.| |||...
Mouse   240 DLYTASVPEMSGVGTSVIQVTATDADDANYGNSAK--VVYSILQGQPYFSVDPESGIIKTALPDM 302

  Fly   474 DREERDFYNVKVIASDNSPSSLFDNGEPN--RGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDA 536
            .||.::.|.|.:.|.|.       .|:..  .|.....|::.|.|::.|.|.|..|.... ||.|
Mouse   303 SRENKEQYQVVIQAKDM-------GGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNS-LESA 359

  Fly   537 NTNTEVIEVKAEDED---NASQILYSIESGNVGDAFKI----GLKTGKITVNQKLDYETITEYEL 594
            ...|.:..:||.|.|   || ::.|||..|...|.|.:    ..:.|.|||.|.||:|....|.|
Mouse   360 PLGTHLGRIKANDPDMGENA-ELEYSIAEGEGSDMFDVITDKDTQEGIITVKQNLDFEKKMLYTL 423

  Fly   595 KVRAFD----------GIYDDYTTVVIKIEDVNDNPPVF-KQDYSVTILEETTYDDCILTVEAYD 648
            :|.|.:          |.:.|...|.|.:||| |.|||| |..|.:.:.|:......|..|.|||
Mouse   424 RVDASNTHPDPRFLHLGPFKDSAMVKISVEDV-DEPPVFSKLSYLMEVDEDVKEGSIIGQVTAYD 487

  Fly   649 PD-----IK---DRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVLIKAND 705
            ||     ||   ||:.|...|:|||..:|:.:|:         |.|||:....|   .:.|.|
Mouse   488 PDAMNNIIKYSVDRHTDMDRVFSIHSENGSIFTL---------KPLDRESSPWH---NITITA-- 538

  Fly   706 EDGVGTTVSTVKE-----VTVTLKDINDNAPFLINEMPVYWQ----ENRNPGHVVQ-LQANDYDD 760
                 |.::..|:     |.:.:.||||:||    |...|::    ||...|.::| :...|.||
Mouse   539 -----TEINNPKQSSQIPVFIRILDINDHAP----EFATYYETFVCENAKSGQLIQTISVMDKDD 594

  Fly   761 TPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILH 825
            .|....|
Mouse   595 PPRGHKF---------------------------------------------------------- 601

  Fly   826 LVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPS 890
                                                            :||    |..:|.|||:
Mouse   602 ------------------------------------------------FFE----PVPEFPLNPN 614

  Fly   891 TGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEF 955

Mouse   615 ----------------------------------------------------------------- 614

  Fly   956 ISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLN 1020
                                                ||::.|:::|.
Mouse   615 ------------------------------------FTIVDNKDNTA------------------ 625

  Fly  1021 GIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQ 1085
            |||.:......|:::..:|                           |.:|:
Mouse   626 GIVTRKDGYSRNKMNTYLL---------------------------PVLIF-------------- 649

  Fly  1086 AQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKIS 1150

Mouse   650 ----------------------------------------------------------------- 649

  Fly  1151 LEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTY 1215
                                              ||.||:
Mouse   650 ----------------------------------DNDYPI------------------------- 655

  Fly  1216 QLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPN 1280
                  |.::..:|:   |:..|..||
Mouse   656 ------QSSTGTLTI---RVCACDNLG-------------------------------------- 673

  Fly  1281 QKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILL 1345
                         |.|:.|                :.|:..:.|:....:|||::|:.:||.:::
Mouse   674 -------------NMQSCN----------------AEALMLAAGLSTGALIAILLCVVILLTLIV 709

  Fly  1346 AVVVQKKQKNGWHEKD-----IDDIRETIINYEDEGGGERDTD-YDLNVLRTQPFYEE-KLYKD- 1402
            .....|:|:    :|:     .||:|:.|:.|.||||||.||. :|:..||.....|: ||.:|
Mouse   710 LFAALKRQR----KKEPLIISKDDVRDNIVTYNDEGGGEEDTQAFDIGTLRNPEAREDSKLRRDV 770

  Fly  1403 -PHALQGNMRDPNDIP-----DIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLA 1461
             |..:   .:....:|     |:.||:..:.:..|.|..|...|.:..|||||:.:...|||||.
Mouse   771 MPETI---FQIRRTVPLWENIDVQDFIHRRLKENDSDPSAPPYDSLATYAYEGNDSVANSLSSLE 832

  Fly  1462 SCTDDGDLNFDYLSNFGPRFRKLADMYGEEPSD 1494
            |.|.|.:.::||||::||||:|||:|||...||
Mouse   833 SLTADCNQDYDYLSDWGPRFKKLAEMYGGNDSD 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	20/59 (34%)
		Cadherin_repeat	417..518	CDD:206637	33/107 (31%)
		Cadherin_repeat	531..619	CDD:206637	35/104 (34%)
		Cadherin_repeat	627..729	CDD:206637	33/114 (29%)
		Cadherin_repeat	736..834	CDD:206637	11/102 (11%)
		LamG	1127..1294	CDD:238058	10/166 (6%)
		Cadherin_C	1358..1489	CDD:279398	55/144 (38%)
Cdh9	XP_011243639.1	Cadherin_repeat	150..233	CDD:206637	18/57 (32%)
		Cadherin_repeat	242..342	CDD:206637	33/108 (31%)
		Cadherin_repeat	350..457	CDD:206637	36/109 (33%)
		Cadherin_repeat	465..562	CDD:206637	33/115 (29%)
		Cadherin_repeat	570..667	CDD:206637	34/499 (7%)
		Cadherin_C	715..861	CDD:366437	58/152 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910