DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shg and Cdh8

DIOPT Version :9

Sequence 1:	NP_476722.1	Gene:	shg / 37386	FlyBaseID:	FBgn0003391	Length:	1507	Species:	Drosophila melanogaster
Sequence 2:	NP_031693.2	Gene:	Cdh8 / 12564	MGIID:	107434	Length:	799	Species:	Mus musculus

Alignment Length:	1263	Identity:	256/1263 - (20%)
Similarity:	371/1263 - (29%)	Gaps:	614/1263 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 LKNFTHPIATLRAVSNMPDKPEVIFELNTGRTEQTNSKNTFVFNQIG-------NEVT--ISLGK 370
            |:.|:.|            :|.::..|:|. .:..:.|..::.:..|       |::|  |...|
Mouse    71 LEEFSGP------------EPILVGRLHTD-LDPGSKKIKYILSGDGAGTIFQINDITGDIHAIK 122

  Fly   371 TLDYEAITDYTLT---MIVRNTHELGTEHQIKIQVEDVNDNI------PYYTEVKSGTILENEPP 426
            .||.|...:||||   :.......|....:..|:|:|:|||.      ||:..|...:||
Mouse   123 RLDREEKAEYTLTAQAVDFETNKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSIL----- 182

  Fly   427 GTPVMQVRAFDMD----GTSANNIVSFELADNREYFTIDPNTGNI-TALTTFDREERDFYNVKVI 486
            ||.|..|.|.|.|    |.||..:  :.:.:.:.||:|:|.|..| |||...|||.::.|.|.:.
Mouse   183 GTSVTNVTATDADDPVYGNSAKLV--YSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQ 245

  Fly   487 ASDNSPSSLFDNGEPNRGHQ-------VFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIE 544
            |.|..            ||.       ...:::.|.||:.|.|.|..|... :.||....|.:..
Mouse   246 AKDMG------------GHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFS-VPEDVVLGTAIGR 297

  Fly   545 VKAEDED---NASQILYSIESGNVGDAFKI----GLKTGKITVNQKLDYETITEYELKVRAFD-- 600
            |||.|:|   || |..|.|..|:....|:|    ..:.|.|.:.:.||:||...|.|||.|.:
Mouse   298 VKANDQDIGENA-QSSYDIIDGDGTALFEITSDAQAQDGVIRLRKPLDFETKKSYTLKVEAANIH 361

  Fly   601 --------GIYDDYTTVVIKIEDVNDNPPVFKQ-DYSVTILEETTYDDCILTVEAYDPDIK---- 652
                    |.:.|..||.|.:||. |.||||.. .|.:.:.|....:..|..|.|.||||.
Mouse   362 IDPRFSSRGPFKDTATVKIVVEDA-DEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPI 425

  Fly   653 ----DRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTV 713
                ||:.|....::|:.:||.         :.|...|||:....|   .:.|       :.|.:
Mouse   426 RFSIDRHTDLERQFNINADDGK---------ITLATPLDRELSVWH---NITI-------IATEI 471

  Fly   714 ---STVKEVTVTLK--DINDNAPFLINEMPVYWQENRNPGHVVQ-LQANDYDDTPGAGNFTFGID 772
               |.:..|.|.:|  |:|||||...:|...:..||..||.|:| :.|.|.||......|.:.:.
Mouse   472 RNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHFFLYSLL 536

  Fly   773 SEA--TPDIKTKFSMDG--DYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVND 833
            .|.  .|:...|.:.|.  ..|..:..|:|:.|:.|.:||.|||||.|..|:.|
Mouse   537 PEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIVISDSGNPPLSSTS----------- 590

  Fly   834 NAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITMLV 898

Mouse   591 ----------------------------------------------------------------- 590

  Fly   899 HTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQ 963

Mouse   591 ----------------------------------------------------------------- 590

  Fly   964 SPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQ 1028
                                                 ||.:|
Mouse   591 -------------------------------------TLTIR----------------------- 595

  Fly  1029 RLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAP 1093

Mouse   596 ----------------------------------------------------------------- 595

  Fly  1094 LMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQID 1158
                             ||.|.:
Mouse   596 -----------------VCGCSN------------------------------------------ 601

  Fly  1159 QGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQR 1223
                                                                       |.::|.
Mouse   602 -----------------------------------------------------------DGVVQS 607

  Fly  1224 TSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCI 1288
            .::|..|            .|||          |.:|.
Mouse   608 CNVEAYV------------LPIG----------LSMGA--------------------------- 623

  Fly  1289 RNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQ 1353
                                                     :|||:.|:.|||:|::..|..::.
Mouse   624 -----------------------------------------LIAILACIILLLVIVVLFVTLRRH 647

  Fly  1354 KNGWHE----KDIDDIRETIINYEDEGGGERDTD-YDLNVLRT----QPFYEEKLYKD-----PH 1404
            ||   |    ||.:|:||.||.|:||||||.||: :|:..|:.    ..|...|..|.     |.
Mouse   648 KN---EPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPR 709

  Fly  1405 ALQGNMRDPNDIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDL 1469
              ||....||.: |:.:|:..:....|.|..|...|.::.|.|||.|:..||||||.|.|.|.|.
Mouse   710 --QGLAPVPNGV-DVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQ 771

  Fly  1470 NFDYLSNFGPRFRKLADMYGEEPSDTDS 1497
            ||||||::||||::|.::|....||.::
Mouse   772 NFDYLSDWGPRFKRLGELYSVGESDKET 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	23/95 (24%)
		Cadherin_repeat	417..518	CDD:206637	32/112 (29%)
		Cadherin_repeat	531..619	CDD:206637	34/104 (33%)
		Cadherin_repeat	627..729	CDD:206637	28/114 (25%)
		Cadherin_repeat	736..834	CDD:206637	31/102 (30%)
		LamG	1127..1294	CDD:238058	9/166 (5%)
		Cadherin_C	1358..1489	CDD:279398	59/144 (41%)
Cdh8	NP_031693.2	CA	87..165	CDD:214520	21/78 (27%)
		Cadherin_repeat	171..272	CDD:206637	35/119 (29%)
		Cadherin_repeat	281..387	CDD:206637	35/108 (32%)
		Cadherin_repeat	395..492	CDD:206637	28/115 (24%)
		Cadherin_repeat	499..602	CDD:206637	37/486 (8%)
		Cadherin_C	645..790	CDD:366437	61/150 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910