DRSC/TRiP Functional Genomics Resources

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Protein Alignment shg and FAT3

DIOPT Version :9

Sequence 1:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster
Sequence 2:XP_016872667.1 Gene:FAT3 / 120114 HGNCID:23112 Length:4612 Species:Homo sapiens


Alignment Length:1948 Identity:433/1948 - (22%)
Similarity:680/1948 - (34%) Gaps:653/1948 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 LGVIVAISLLSPALALHSPPDKNFSGDNRKPAFKNCAGYAPKVKEEQPENTYVLTVEAVDPDPDQ 119
            |.|.|:..|.:....:|.   :....:...|||.. :.|..:|:|.....|.|:.|.|.|.||..
Human  2490 LNVSVSDGLFTSTAQVHI---RVLGANLYSPAFSQ-STYVAEVRENVAAGTKVIHVRATDGDPGT 2550

  Fly   120 V--IRYSIVQSPFERPKFFINPSTGVIFTTHTFDRDEPIHEKFVFVTVQATDNGLPPLDDVCTFN 182
            .  |.|:|: :.|.:.:|.|: |.|.:.||...||:.|: |..|.:.|:|.|.|  .....||..
Human  2551 YGQISYAII-NDFAKDRFLID-SNGQVITTERLDRENPL-EGDVSIFVRALDGG--GRTTFCTVR 2610

  Fly   183 VTIEDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDDGNNSLVEYEILRERDF---QYFK 244
            |.:.|.|||||.|....|..|:..:.....:|..:.|.|.|||.||.:.|.:..|...   ...:
Human  2611 VIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLE 2675

  Fly   245 IDKESGIIYLKRPIDKRPGQSYAIIVRAYNVVPD---PPQDAQIEVRIRVVESSIKPPSFV---- 302
            ||.::|.:..|...::......:..|:|.    |   |.:.:.|.|.|.|:......|||.    
Human  2676 IDPDNGWMVTKGNFNQLKNTVLSFFVKAV----DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQY 2736

  Fly   303 -----------NPIDT----------------------------------PIYLKENLKNFTHPI 322
                       :.:||                                  .|.|.:.|...|.|.
Human  2737 SFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPA 2801

  Fly   323 ATLRAVSNMP-DKPEVIF---------ELNTGR-TEQTNSKNTFV-------------------- 356
            ...:..:.:| ||.:::|         :||..: ..:|:|.:|.:                    
Human  2802 FHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDW 2866

  Fly   357 ----------------------FNQIGNEVTISLGKTLDYEAITDYTLTMIVRNTHE---LGTEH 396
                                  ||...|...||..|.||:|....:|.:::..:..|   |.:..
Human  2867 GANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTA 2931

  Fly   397 QIKIQVEDVNDNIPYYT-EVKSGTILENEPPGTPVMQVRAFDMDGTSANNIVSFEL--------- 451
            .:.::|.|:|||.|.:. ||..|.:.|::|||..|..:..:|.|.:..|..||:.:         
Human  2932 LVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRF 2996

  Fly   452 ----------------------------------------------------------------- 451
                                                                             
Human  2997 ALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALL 3061

  Fly   452 -----------------AD---------------NREYFTIDPNTGNITALT------------- 471
                             ||               |.|:| :||.:|.:..|.             
Human  3062 PEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLALLDRERIPVYSLM 3125

  Fly   472 ----------------------------------------------------------------- 471
                                                                             
Human  3126 AKATDGGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVV 3190

  Fly   472 ------------------------TFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISI 512
                                    ..|||::..||:.|.|:|.||      |:.........|::
Human  3191 YSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSP------GQSLSSLTTVTITV 3249

  Fly   513 GDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDED---NASQILYSIESGNVGDAFKIGLK 574
            .|.||:.|.|::..||. .:.||.:..|:|:.|.|..:|   || :|.|.|.|||....|||..|
Human  3250 LDINDNPPVFERRDYLV-TVPEDTSPGTQVLAVFATSKDIGTNA-EITYLIRSGNEQGKFKINPK 3312

  Fly   575 TGKITVNQKLDYETITEYELKVRAFDG---IYDDYTTVVIKIEDVNDNPPVFKQD-YSVTILEET 635
            ||.|:|::.||||....:.|.|.|.||   ......||.|.:.|||||||.|.|| ||..|.|:.
Human  3313 TGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDA 3377

  Fly   636 TYDDCILTVEAYDPDIKDRNADQHIVYSIHQND-GNRWTIDN-SGCLRLVKTLDRDPPNGHKNWQ 698
            ...|.::.:.|.|.| ...|...|  :||...| .|.:|:|. .|.:::.|.|||:..:|   :.
Human  3378 LVGDSVILLIAEDVD-SQPNGQIH--FSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSG---YS 3436

  Fly   699 VLIKANDEDGVGTTVSTVKEVTVTLKDINDNAP-FLINEMPVYWQENRNPG-HVVQLQANDYDDT 761
            :|::|.| .|: ..:|:...|.:.:.|:|||:| |.........|||:..| .::||...|.|..
Human  3437 LLVQAVD-SGI-PAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSF 3499

  Fly   762 PGAGNFTFGIDSEATPDIKTKFSMD-GDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILH 825
            .....|:|.|   .:.:.:.:|.:| ...|.:.|.|......||.:.::..|||.|:|.:.:.:.
Human  3500 HNGPPFSFSI---LSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIR 3561

  Fly   826 LVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPS 890
            :.:.:.:.:..:.....|||...:.:.|...||::...|.|.:|:  ..|..|......|::|..
Human  3562 VRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDMYDV--LTFALKSEQKSLFKVNSH 3624

  Fly   891 TGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEF 955
            .|.|..|.....|:|.|:..|::....||   :|  |.|.|.:|..|.:..:.:|||.||:.|:|
Human  3625 DGKIIALGGLDSGKYVLNVSVSDGRFQVP---ID--VVVHVEQLVHEMLQNTVTIRFENVSPEDF 3684

  Fly   956 ISV-----PRDFQSPDALSLKDRLQ-LSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSA--HGSP 1012
            :.:     .|..::......:|.|: :|:..:..|               :.||:.|:.  |.|.
Human  3685 VGLHMHGFRRTLRNAVLTQKQDSLRIISIQPVAGT---------------NQLDMLFAVEMHSSE 3734

  Fly  1013 YYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEK----FKCEES-CTNELHKSSVPYMIYS 1072
            :|.|..|...::..::.|||.:.:        ..::||    ..|:|. |...|...|...|.||
Human  3735 FYKPAYLIQKLSNARRHLENIMRI--------SAILEKNCSGLDCQEQHCEQGLSLDSHALMTYS 3791

  Fly  1073 NT-TSFVGVNAFVQAQCVCEAPLMRRCLNGG-SPRYGEND-----------------------VC 1112
            .. .|||....:...:|.|         ||| .|  |.||                       :|
Human  3792 TARISFVCPRFYRNVRCTC---------NGGLCP--GSNDPCVEKPCPGDMQCVSYEASRRPFLC 3845

  Fly  1113 DCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNT-----KISLEITPQIDQGLIMYL------- 1165
            .|..|..|......|::|.|:.|..|.   ...|:     |::|.:......|:|||.       
Human  3846 QCPPGKLGECSGHTSLSFAGNSYIKYR---LSENSKEEDFKLALRLRTLQSNGIIMYTRANPCII 3907

  Fly  1166 -----GPLNFN-------PLLAIS------------------DFLALELDNGY------PVL--T 1192
                 |.|.|.       .:|.||                  :|.:|.||:.|      |:.  |
Human  3908 LKIVDGKLWFQLDCGSGPGILGISGRAVNDGSWHSVFLELNRNFTSLSLDDSYVERRRAPLYFQT 3972

  Fly  1193 VDYGS----GAIRIRHQHIKMVAD-RTYQ--------LDIIL----------QRTSIEMTV---- 1230
            :...|    ||: ::..:|:.:.| |..|        ||.::          :|:|....|    
Human  3973 LSTESSIYFGAL-VQADNIRSLTDTRVTQVLSGFQGCLDSVILNNNELPLQNKRSSFAEVVGLTE 4036

  Fly  1231 ---------DNCRLSTCQ----TLGAPIGP------NEFLNVNA----------PLQLGGT--PV 1264
                     |.|:.|.||    ..|.|.|.      ::|...|.          |.:.||:  |:
Human  4037 LKLGCVLYPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPI 4101

  Fly  1265 -------------------DLEQLGRQ--LNWTHVPNQKGFFGCIRNLTINEQTYNLGM-PSVFR 1307
                               |:.:..|:  .|.....|..|.|.|  |.|........|: |.|..
Human  4102 GNTFICNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFLC--NCTPGYVGQYCGLRPVVVP 4164

  Fly  1308 NIDSGCQQSVAVAFSFGIDRNFIIAI-IVCLALLLIILLAVVVQKK--QKNGWHEKDIDDIRETI 1369
            ||.:|        .|: :.:..:|.| :|...:.::::|.:|.:||  :||              
Human  4165 NIQAG--------HSY-VGKEELIGIAVVLFVIFILVVLFIVFRKKVFRKN-------------- 4206

  Fly  1370 INYEDEGGGERDTDYDLNVLRTQPFYEEKLYKDPHALQGNMRDPNDIPDIADF-----LGDKKEN 1429
                          |..|.:        .|.:|| |....:...|.||    |     .||.: |
Human  4207 --------------YSRNNI--------TLVQDP-ATAALLNKSNGIP----FRNLRGSGDGR-N 4243

  Fly  1430 CDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRFRKLADMYGEEP 1492
            ..::||...| .||..||.....|| |.|:|....|          ..|...:::...:.|.|
Human  4244 VYQEVGPPQV-PVRPMAYTPCFQSD-SRSNLDKIVD----------GLGGEHQEMTTFHPESP 4294

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637 34/99 (34%)
Cadherin_repeat 200..292 CDD:206637 23/97 (24%)
CA 332..410 CDD:214520 26/133 (20%)
Cadherin_repeat 417..518 CDD:206637 34/308 (11%)
Cadherin_repeat 531..619 CDD:206637 38/93 (41%)
Cadherin_repeat 627..729 CDD:206637 30/103 (29%)
Cadherin_repeat 736..834 CDD:206637 23/99 (23%)
LamG 1127..1294 CDD:238058 60/295 (20%)
Cadherin_C 1358..1489 CDD:279398 27/135 (20%)
FAT3XP_016872667.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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