Protein Alignment shg and CDH6

DIOPT Version :10

• Sequence 1: NP_476722.1
• Gene: shg / 37386
• FlyBaseID: FBgn0003391
• Length: 1507
• Species: Drosophila melanogaster
• Sequence 2: NP_004923.1
• Gene: CDH6 / 1004
• HGNCID: 1765
• Length: 790
• Species: Homo sapiens
• Alignment Length: 1274
• Identity: 276/1274 - (21%)
• Similarity: 399/1274 - (31%)
• Gaps: 596/1274 - (46%)

  Fly   321 PIATL-----RAVSNMPDKPEVIFELNTGRTEQTNSKNTFVFNQ--------------------- 359
            |..||     :..|..|.|...:......:.|...||.::::||
Human    16 PYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSD 80

  Fly   360 ---------------------IGNEVT--ISLGKTLDYEAITDYTL--TMIVRNT-HELGTEHQI 398
                                 |.||.|  |...|.||.|....|.|  ..|.|.| ..:..|.:.
Human    81 QDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEF 145

  Fly   399 KIQVEDVNDNIPYYT-EVKSGTILENEPPGTPVMQVRAFDMD----GTSANNIVSFELADNREYF 458
            .|::.|:|||.|.:| ||.:.|:.|....||.|:||.|.|.|    |.||.  |.:.:...:.||
Human   146 IIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAK--VVYSILQGQPYF 208

  Fly   459 TIDPNTGNI-TALTTFDREERDFYNVKVIASDNSPSSLFDNGEPN--RGHQVFRISIGDKNDHKP 520
            :::..||.| |||...|||.|:.|.|.:.|.|.       .|:..  .|.....|::.|.||:.|
Human   209 SVESETGIIKTALLNMDRENREQYQVVIQAKDM-------GGQMGGLSGTTTVNITLTDVNDNPP 266

  Fly   521 HFQQDKYLAERLLEDANTNTEVIEVKAEDED---NASQILYSIESGNVGDAFKI----GLKTGKI 578
            .|.|..| ..:..|.:...|.:..:||.|.|   || :|.|||..|...|.|.:    ..:.|.|
Human   267 RFPQSTY-QFKTPESSPPGTPIGRIKASDADVGENA-EIEYSITDGEGLDMFDVITDQETQEGII 329

  Fly   579 TVNQKLDYETITEYELKVRA----------FDGIYDDYTTVVIKIEDVNDNPPVF-KQDYSVTIL 632
            ||.:.||:|....|.|||.|          :.|.:.|..||.|.:||| |.|||| |..|.:.|.
Human   330 TVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDV-DEPPVFSKLAYILQIR 393

  Fly   633 EETTYDDCILTVEAYDPD-----IK---DRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRD 689
            |:...:..|.:|.|.|||     :|   ||:.|...:::|...:|:.:|         .|.|||:
Human   394 EDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFT---------SKLLDRE 449

  Fly   690 PPNGHKNWQVLIKANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQ 754
            ....|                       .:||...:||:
Human   450 TLLWH-----------------------NITVIATEINN-------------------------- 465

  Fly   755 ANDYDDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQS 819
                                                                         |:||
Human   466 -------------------------------------------------------------PKQS 469

  Fly   820 AVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQ 884
            :...|::.:.|||||                 |||      |.:          ::|
Human   470 SRVPLYIKVLDVNDN-----------------APE------FAE----------FYE-------- 493

  Fly   885 FRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFIN 949
                      |.:...|:.          |.:....|:||       ::.|......|.|:
Human   494 ----------TFVCEKAKA----------DQLIQTLHAVD-------KDDPYSGHQFSFSL---- 527

  Fly   950 VTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYY 1014
                          :|:|                .|.||   ||:..|:::|..:
Human   528 --------------APEA----------------ASGSN---FTIQDNKDNTAGI---------- 549

  Fly  1015 APEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVG 1079
                                                                             
Human   550 ----------------------------------------------------------------- 549

  Fly  1080 VNAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAAC 1144
                          |.|:                                   :||..:|
Human   550 --------------LTRK-----------------------------------NGYNRHE----- 560

  Fly  1145 NNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKM 1209
                            :..||.|      :.||       ||.|||
Human   561 ----------------MSTYLLP------VVIS-------DNDYPV------------------- 577

  Fly  1210 VADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLN 1274
                        |.::..:||   |:..|...|
Human   578 ------------QSSTGTVTV---RVCACDHHG-------------------------------- 595

  Fly  1275 WTHVPNQKGFFGCIRNLTINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLAL 1339
                                             |:.| | .:.|:....|:....::||::|:.:
Human   596 ---------------------------------NMQS-C-HAEALIHPTGLSTGALVAILLCIVI 625

  Fly  1340 LL--IILLAVVVQKKQKNGWHEKDI---DDIRETIINYEDEGGGERDTD-YDLNVLRTQPFYEE- 1397
            ||  ::|.|.:.::::|    |..|   :|||:.|::|.||||||.||. :|:..||.....|:
Human   626 LLVTVVLFAALRRQRKK----EPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDN 686

  Fly  1398 KLYKD--PHALQGNMRDP--NDIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLS 1458
            ||.:|  |.||....|.|  .|..|:.||:..:.:..|.|..|...|.:..|||||.|:...|||
Human   687 KLRRDIVPEALFLPRRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLS 751

  Fly  1459 SLASCTDDGDLNFDYLSNFGPRFRKLADMYGEEPSDTDS 1497
            ||.|.|.|.|.::||||::||||:|||||||...||.||
Human   752 SLESVTTDADQDYDYLSDWGPRFKKLADMYGGVDSDKDS 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	27/124 (22%)
		Cadherin_repeat	417..518	CDD:206637	35/107 (33%)
		Cadherin_repeat	531..619	CDD:206637	35/104 (34%)
		Cadherin_repeat	627..729	CDD:206637	25/109 (23%)
		Cadherin_repeat	736..834	CDD:206637	7/97 (7%)
		LamG	1127..1294	CDD:238058	19/166 (11%)
		CADH_Y-type_LIR	1430..1489	CDD:460041	32/58 (55%)
CDH6	NP_004923.1	CA	79..157	CDD:214520	20/77 (26%)
		Cadherin_repeat	163..264	CDD:206637	36/109 (33%)
		Cadherin_repeat	272..379	CDD:206637	36/109 (33%)
		Cadherin_repeat	388..484	CDD:206637	32/214 (15%)
		Cadherin_repeat	492..589	CDD:206637	38/360 (11%)
		CADH_Y-type_LIR	723..782	CDD:460041	32/58 (55%)