DRSC/TRiP Functional Genomics Resources

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Protein Alignment shg and CDH4

DIOPT Version :10

Sequence 1:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster
Sequence 2:NP_001785.2 Gene:CDH4 / 1002 HGNCID:1763 Length:916 Species:Homo sapiens


Alignment Length:1183 Identity:258/1183 - (21%)
Similarity:428/1183 - (36%) Gaps:406/1183 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   412 YTEVKSGTILENEPPGTPVMQVRAFDMDGTSA----NNIVSFEL-ADNREYFTID---PNTGNIT 468
            ||.:.|..|||    |..::||:.....||..    .|.:.|:: ||...:.|.:   |:.....
Human    40 YTALISQNILE----GEKLLQVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAF 100

  Fly   469 ALTTFDREERDFYNVKV---IASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHK------PHFQQ 524
            .:|.:|.:..:.::..|   :|..:||.|   ..:|.:|.:|  :::......|      |..|.
Human   101 TVTAWDSQTAEKWDAVVRLLVAQTSSPHS---GHKPQKGKKV--VALDPSPPPKDTLLPWPQHQN 160

  Fly   525 DKYLAER----LLEDANT--NT------EVIEVKAEDEDNASQILYSIESGNVG------DAFKI 571
            ...|..|    ::...|.  |:      :::.::: |:||...|.|||.  .||      :.|.|
Human   161 ANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRS-DKDNDIPIRYSIT--GVGADQPPMEVFSI 222

  Fly   572 GLKTGKITVNQKLDYETITEYELKVRAFD---GIYDDYTTVVIKIEDVNDNPPVF-KQDYSVTIL 632
            ...:|::.|.:.:|.|....|.|:..|.|   ...::...:.|.:.|:|||.|.| .|.|:.::.
Human   223 DSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVD 287

  Fly   633 EETTYDDCILTVEAYDPDIKDRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNW 697
            |.:.....::||.|.|.| ....|:..:.|                  |:|....:.|.      
Human   288 EGSKPGTYVMTVTANDAD-DSTTANGMVRY------------------RIVTQTPQSPS------ 327

  Fly   698 QVLIKANDEDGVGTTVST------VKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQAN 756
            |.:...|.|.|...||:.      |::.||.                              :||.
Human   328 QNMFTINSETGDIVTVAAGLDREKVQQYTVI------------------------------VQAT 362

  Fly   757 DYDDTPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAV 821
            |.:     ||..:|:.:.||..|                                          
Human   363 DME-----GNLNYGLSNTATAII------------------------------------------ 380

  Fly   822 SILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFR 886
                 .:.|||||.....:|     .:.||.||..:..| |.:|...|        :|.||    
Human   381 -----TVTDVNDNPPEFTAS-----TFAGEVPENRVETV-VANLTVMD--------RDQPH---- 422

  Fly   887 LNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVT 951
             :|:...:..::   .|:....|.|..|.:     :.:..||||      :|||       ..:.
Human   423 -SPNWNAVYRII---SGDPSGHFSVRTDPV-----TNEGMVTVV------KAVD-------YELN 465

  Fly   952 KEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYY-A 1015
            :...::|....|:|    |...:|:|.......::|.:|:     ||            :||: :
Human   466 RAFMLTVMVSNQAP----LASGIQMSFQSTAGVTISIMDI-----NE------------APYFPS 509

  Fly  1016 PEKLNGIVAQNQQRLENELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGV 1080
            ..||        .|||..:....::........::|.          :.:|.|...|:..|::.:
Human   510 NHKL--------IRLEEGVPPGTVLTTFSAVDPDRFM----------QQAVRYSKLSDPASWLHI 556

  Fly  1081 NAFVQAQCVCEAPLMRRCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACN 1145
            || ...|....|.|.|..|      |.:|:|                          ||      
Human   557 NA-TNGQITTAAVLDRESL------YTKNNV--------------------------YE------ 582

  Fly  1146 NTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMV 1210
                                           :.|||  .|||.|..:   |:|.::|        
Human   583 -------------------------------ATFLA--ADNGIPPAS---GTGTLQI-------- 603

  Fly  1211 ADRTYQLDIILQRTSIEMTVDNCRLSTCQTLGA------------PIGPNEFLNVNAPLQLGGTP 1263
                |.:||  ...:.|:.....::.....|.|            .|||..|       :|...|
Human   604 ----YLIDI--NDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVF-------ELPFVP 655

  Fly  1264 VDLEQLGRQLNWTHVPNQKGFFG--CIRNLTINEQTYNL-------GMPSVFRNI---------- 1309
            ..:.:     ||| :....|.:.  .:|.|.:....|::       |.|.:....          
Human   656 AAVRK-----NWT-ITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCD 714

  Fly  1310 DSGCQQSVAVAFSFGIDRNFIIAIIVCLALLL-IILLAVVVQKKQKNGWHEKDI-----DDIRET 1368
            |:|...::....:.|:....|:||::|:.:|| ::||.|:..|:::...|.|.:     ||:|:.
Human   715 DNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDN 779

  Fly  1369 IINYEDEGGGERDTDYDLNVLRTQPFYEEKLYKDPHALQGNMRDPNDIP---------------- 1417
            |:.|::|||||.|.||||:.|: ||   |.:...|....| :|..::.|                
Human   780 ILKYDEEGGGEEDQDYDLSQLQ-QP---EAMGHVPSKAPG-VRRVDERPVGAEPQYPIRPMVPHP 839

  Fly  1418 -DIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFDYLSNFGPRF 1481
             ||.||:.:.....|.|..|...|.:..:.|||.|::.||:|||.| :..||.::|||:::||||
Human   840 GDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNS-SSSGDQDYDYLNDWGPRF 903

  Fly  1482 RKLADMYGEEPSD 1494
            :|||||||....|
Human   904 KKLADMYGGGEED 916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637
Cadherin_repeat 200..292 CDD:206637
CA 332..410 CDD:214520
Cadherin_repeat 417..518 CDD:206637 25/111 (23%)
Cadherin_repeat 531..619 CDD:206637 25/108 (23%)
Cadherin_repeat 627..729 CDD:206637 21/107 (20%)
Cadherin_repeat 736..834 CDD:206637 12/97 (12%)
LamG 1127..1294 CDD:238058 30/180 (17%)
CADH_Y-type_LIR 1430..1489 CDD:460041 28/58 (48%)
CDH4NP_001785.2 Cadherin_pro 30..119 CDD:462590 20/82 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 124..168 10/48 (21%)
CA_like 173..273 CDD:481204 24/102 (24%)
Cadherin_repeat 281..388 CDD:206637 33/213 (15%)
Cadherin_repeat 396..503 CDD:206637 31/150 (21%)
Cadherin_repeat 514..611 CDD:206637 33/195 (17%)
CA_like 619..711 CDD:481204 17/104 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 806..838 4/32 (13%)
CADH_Y-type_LIR 853..911 CDD:460041 28/58 (48%)
Blue background indicates that the domain is not in the aligned region.

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