DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3295 and RMD5

DIOPT Version :9

Sequence 1:	NP_611536.1	Gene:	CG3295 / 37382	FlyBaseID:	FBgn0034573	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	NP_010541.3	Gene:	RMD5 / 851842	SGDID:	S000002663	Length:	421	Species:	Saccharomyces cerevisiae

Alignment Length:	422	Identity:	104/422 - (24%)
Similarity:	187/422 - (44%)	Gaps:	72/422 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EVLSRAEQLVTTLNSSTQVSQDDPMGDAVSMQVETEPTAPQRLTERQVESVRNALARCHER-VQK 108
            |..|:.::|...||...|               |::|....:|::::.:..:    |..|. ::|
Yeast    35 EFKSQLKKLKAHLNKHIQ---------------ESKPEVYNKLSDKEKQKFK----RKRELIIEK 80

  Fly   109 LSTEHRDLHGSISKIGKAIDRNFSADFSSTMR------VDVLQ----DEENLMLLNKAIAKHYCR 163
            ||...|....|:.|..|.:.:..:....||:.      :|.:.    .:|.:..:|:||..|..|
Yeast    81 LSKSQRQWDHSVKKQIKYVSQQSNRFNKSTLNKLKEFDIDSVYVNKLPKETMENVNEAIGYHILR 145

  Fly   164 QGMDDVARTLIRECKMSPEHAQDVF----DSEREFADIYGIWVKIQKRDLTDALKWAKMYSQQLS 224
            ..:|::.   :.....:.::.:||:    ....||.::..|...::|.|....|||.....:.||
Yeast   146 YSIDNMP---LGNKNEAFQYLKDVYGITNKESTEFIEMGQIVHDLKKGDTESCLKWCSNEMESLS 207

  Fly   225 DRH---SLIEFRLHRMRFMQLVSYG--LDSQREAISYARLNFKKFAVRYEHEIANLMASFIYLPS 284
            ..|   |.::|.|:.:..||:|.:|  ::...:....|.|:.      :.|....||.:.:.|.:
Yeast   208 SNHTALSSLKFDLYTLSAMQIVKHGNPVELYYQITQNAPLDC------FRHREKELMQNVVPLLT 266

  Fly   285 GLENSPYKHFLGQ----------EKWTELSFIFLKDACQLLGISKNSALSVVVNAGCTALPALLN 339
                   |..:||          ::..|.:.:|:|:.|....|..:|.|.::|.:|..:....:.
Yeast   267 -------KSLIGQPIEDIDSKVNKELKECTSLFIKEYCAAKHIFFDSPLFLIVLSGLISFQFFIK 324

  Fly   340 IKQVMQSRQVLGMWNGCDELPIEIDLQPEF--RFHSIFACPILRQQTSEDNPPKKLTCGHVISND 402
            .|.:.:...|  .|...||||.::.| |:|  .||.||.||:|:::|:.:|||..|.|.|:||..
Yeast   325 YKTIRELAHV--DWTTKDELPFDVKL-PDFLTHFHPIFICPVLKEETTTENPPYSLACHHIISKK 386

  Fly   403 ALHKLSVGHIL--KCPYCPVEQNAEEAVRIYF 432
            ||.:||....:  |||||||..:.....::.|
Yeast   387 ALDRLSKNGTITFKCPYCPVNTSMSSTKKVRF 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3295	NP_611536.1	COG5109	88..432	CDD:227440	94/377 (25%)
		LisH	152..181	CDD:128913	6/28 (21%)
		CTLH	193..250	CDD:128914	18/61 (30%)
		CRA	252..343	CDD:214806	19/100 (19%)
		zf-RING_UBOX	377..416	CDD:290181	17/40 (43%)
RMD5	NP_010541.3	COG5109	13..418	CDD:227440	103/420 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344111
Domainoid	1	1.000	76	1.000	Domainoid score	I2113
eggNOG	1	0.900	-	-		E1_COG5109
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	112	1.000	Inparanoid score	I1367
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55101
OrthoFinder	1	1.000	-	-		FOG0002102
OrthoInspector	1	1.000	-	-		oto99896
orthoMCL	1	0.900	-	-		OOG6_102297
Panther	1	1.100	-	-	LDO	PTHR12170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1719
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790