DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3295 and RMND5A

DIOPT Version :9

Sequence 1:	NP_611536.1	Gene:	CG3295 / 37382	FlyBaseID:	FBgn0034573	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	NP_073617.1	Gene:	RMND5A / 64795	HGNCID:	25850	Length:	391	Species:	Homo sapiens

Alignment Length:	432	Identity:	175/432 - (40%)
Similarity:	260/432 - (60%)	Gaps:	51/432 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CSSVEKDLTRVVSKLE---QLHENAEADIGDIATQMSELVEVLSRAEQLVTTLNSSTQVSQDDPM 69
            |.:||::|.:|:.|..   ||.|..          :.||::.....:..:  |.|.   .||..:
Human     4 CVTVERELEKVLHKFSGYGQLCERG----------LEELIDYTGGLKHEI--LQSH---GQDAEL 53

  Fly    70 GDAVSMQVETEPTAPQRLTERQVESVRNALARCHER----VQKLSTEHRDLHGSISKIGKAIDRN 130
            ...:|:                      .|.:|.:|    ||||:::|:|:|.|:|::|||||:|
Human    54 SGTLSL----------------------VLTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKN 96

  Fly   131 FSADFSSTMRVDVLQDEENLMLLNKAIAKHYCRQGMDDVARTLIRECKMSPEHAQDVFDSEREFA 195
            |.:|.|| :.:|.....::..|||:.:.:|:.||||.|||..|.:|..:|.:.:|     :..|.
Human    97 FDSDISS-VGIDGCWQADSQRLLNEVMVEHFFRQGMLDVAEELCQESGLSVDPSQ-----KEPFV 155

  Fly   196 DIYGIWVKIQKRDLTDALKWAKMYSQQLSDRHSLIEFRLHRMRFMQLVSYGLDSQREAISYARLN 260
            ::..|...::.|.|..||:||....:.|..::|.:||:|||:.|:.|:..|..:||||:.||: |
Human   156 ELNRILEALKVRVLRPALEWAVSNREMLIAQNSSLEFKLHRLYFISLLMGGTTNQREALQYAK-N 219

  Fly   261 FKKFAVRYEHEIANLMASFIYLPSGLENSPYKHFLGQEKWTELSFIFLKDACQLLGISKNSALSV 325
            |:.||:.::.:|..||.|.:||..|:|||||.|.|...:|.::..||.:|||.|||:|..|.|||
Human   220 FQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDANQWADICDIFTRDACALLGLSVESPLSV 284

  Fly   326 VVNAGCTALPALLNIKQVMQSRQVLGMWNGCDELPIEIDLQPEFRFHSIFACPILRQQTSEDNPP 390
            ..:|||.|||||:|||.|::.||..|:||..||||||:||..:..:|||||||||||||:::|||
Human   285 SFSAGCVALPALINIKAVIEQRQCTGVWNQKDELPIEVDLGKKCWYHSIFACPILRQQTTDNNPP 349

  Fly   391 KKLTCGHVISNDALHKLSVGHILKCPYCPVEQNAEEAVRIYF 432
            .||.|||:||.|||:|:..|..|||||||:||:..:|.:|:|
Human   350 MKLVCGHIISRDALNKMFNGSKLKCPYCPMEQSPGDAKQIFF 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3295	NP_611536.1	COG5109	88..432	CDD:227440	158/347 (46%)
		LisH	152..181	CDD:128913	13/28 (46%)
		CTLH	193..250	CDD:128914	18/56 (32%)
		CRA	252..343	CDD:214806	47/90 (52%)
		zf-RING_UBOX	377..416	CDD:290181	25/38 (66%)
RMND5A	NP_073617.1	COG5109	17..391	CDD:227440	169/417 (41%)
RMND5A	NP_073617.1	CLTH	153..297	CDD:402305	63/144 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147970
Domainoid	1	1.000	123	1.000	Domainoid score	I5595
eggNOG	1	0.900	-	-		E1_COG5109
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5668
Inparanoid	1	1.050	313	1.000	Inparanoid score	I2577
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55101
OrthoDB	1	1.010	-	-		D576638at33208
OrthoFinder	1	1.000	-	-		FOG0002102
OrthoInspector	1	1.000	-	-		otm41683
orthoMCL	1	0.900	-	-		OOG6_102297
Panther	1	1.100	-	-	O	PTHR12170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1719
SonicParanoid	1	1.000	-	-		X1554
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800