DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3295 and rmnd5b

DIOPT Version :9

Sequence 1:	NP_611536.1	Gene:	CG3295 / 37382	FlyBaseID:	FBgn0034573	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	NP_957068.1	Gene:	rmnd5b / 393747	ZFINID:	ZDB-GENE-040426-1744	Length:	391	Species:	Danio rerio

Alignment Length:	431	Identity:	175/431 - (40%)
Similarity:	254/431 - (58%)	Gaps:	49/431 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CSSVEKDLTRVVSKLEQLHENAEADIGDIATQMSELVEVLSRAEQLVTTLNSSTQVSQDDPMGDA 72
            |:.||::|.:|:.:.......:|..:.::...:.||     |:..|                  |
Zfish     4 CACVERELEKVLHRFVTYGHQSEERLDELLNNVCEL-----RSRLL------------------A 45

  Fly    73 VSMQVETEPTAPQRLTERQVESVRNALARC----HERVQKLSTEHRDLHGSISKIGKAIDRNFSA 133
            ..:|            :..:..:...:|:|    .|.||.|::.|:|:|||:||:||||||||.|
Zfish    46 YGVQ------------DADLSVLHQTMAQCCKEIKETVQMLASRHKDIHGSVSKVGKAIDRNFDA 98

  Fly   134 DFSSTMRVDVLQDEENLMLLNKAIAKHYCRQGMDDVARTLIRECKMSPEHAQDVFD--SEREFAD 196
            :.|:.:..:|....|....|::.|.:|..||||..||..|.:|..:       |.|  .::.|.:
Zfish    99 EVSAVVAENVWDSPERQKYLSETIVEHLYRQGMLSVAEDLCQESGV-------VIDMSMKQPFLE 156

  Fly   197 IYGIWVKIQKRDLTDALKWAKMYSQQLSDRHSLIEFRLHRMRFMQLVSYGLDSQREAISYARLNF 261
            :..|...::.:||..||:||....|:|.|.:|.:||:|||:.|:.|::.|:..|:||:.||| :|
Zfish   157 LNRILEALRTQDLRPALEWAVTNRQRLLDLNSTLEFKLHRLYFISLLNGGIGKQQEALQYAR-HF 220

  Fly   262 KKFAVRYEHEIANLMASFIYLPSGLENSPYKHFLGQEKWTELSFIFLKDACQLLGISKNSALSVV 326
            :.||.:::.:|..||.|.:||..|:|||||:..|..::|.|:..||.:|||.|||:|..|.|||.
Zfish   221 QPFASQHQRDIQILMGSLVYLRHGIENSPYRSLLETDQWAEICNIFTRDACALLGLSVESPLSVS 285

  Fly   327 VNAGCTALPALLNIKQVMQSRQVLGMWNGCDELPIEIDLQPEFRFHSIFACPILRQQTSEDNPPK 391
            ..:||.|||.|:|||||::.||..|:|...|||||||||..:..:||:||||||||||||.|||.
Zfish   286 FASGCMALPVLMNIKQVIEQRQCSGVWTHKDELPIEIDLGKKCWYHSVFACPILRQQTSESNPPM 350

  Fly   392 KLTCGHVISNDALHKLSVGHILKCPYCPVEQNAEEAVRIYF 432
            ||.||||||.|||:||:....|||||||:|||..:|.:|||
Zfish   351 KLICGHVISRDALNKLTNAGKLKCPYCPMEQNPSDAKQIYF 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3295	NP_611536.1	COG5109	88..432	CDD:227440	161/349 (46%)
		LisH	152..181	CDD:128913	11/28 (39%)
		CTLH	193..250	CDD:128914	20/56 (36%)
		CRA	252..343	CDD:214806	45/90 (50%)
		zf-RING_UBOX	377..416	CDD:290181	28/38 (74%)
rmnd5b	NP_957068.1	CLTH	153..297	CDD:287564	62/144 (43%)
		CTLH	154..206	CDD:128914	19/51 (37%)
		CRA	208..302	CDD:214806	46/94 (49%)
		zf-RING_UBOX	336..375	CDD:290181	28/38 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581864
Domainoid	1	1.000	123	1.000	Domainoid score	I5556
eggNOG	1	0.900	-	-		E1_COG5109
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2583
OMA	1	1.010	-	-		QHG55101
OrthoDB	1	1.010	-	-		D576638at33208
OrthoFinder	1	1.000	-	-		FOG0002102
OrthoInspector	1	1.000	-	-		oto40538
orthoMCL	1	0.900	-	-		OOG6_102297
Panther	1	1.100	-	-	LDO	PTHR12170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1719
SonicParanoid	1	1.000	-	-		X1554
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840