DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3295 and Rmnd5a

DIOPT Version :9

Sequence 1:	NP_611536.1	Gene:	CG3295 / 37382	FlyBaseID:	FBgn0034573	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	XP_038964634.1	Gene:	Rmnd5a / 312439	RGDID:	1309766	Length:	391	Species:	Rattus norvegicus

Alignment Length:	432	Identity:	175/432 - (40%)
Similarity:	260/432 - (60%)	Gaps:	51/432 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CSSVEKDLTRVVSKLE---QLHENAEADIGDIATQMSELVEVLSRAEQLVTTLNSSTQVSQDDPM 69
            |.:||::|.:|:.|..   ||.|..          :.||::.....:..:  |.|.   .||..:
  Rat     4 CVTVERELEKVLHKFSGYGQLCERG----------LEELIDYTGGLKHEI--LQSH---GQDAEL 53

  Fly    70 GDAVSMQVETEPTAPQRLTERQVESVRNALARCHER----VQKLSTEHRDLHGSISKIGKAIDRN 130
            ...:|:                      .|.:|.:|    ||||:::|:|:|.|:|::|||||:|
  Rat    54 SGTLSL----------------------VLTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKN 96

  Fly   131 FSADFSSTMRVDVLQDEENLMLLNKAIAKHYCRQGMDDVARTLIRECKMSPEHAQDVFDSEREFA 195
            |.:|.|| :.:|.....::..|||:.:.:|:.||||.|||..|.:|..:|.:.:|     :..|.
  Rat    97 FDSDISS-VGIDGCWQADSQRLLNEVMVEHFFRQGMLDVAEELCQESGLSVDPSQ-----KEPFV 155

  Fly   196 DIYGIWVKIQKRDLTDALKWAKMYSQQLSDRHSLIEFRLHRMRFMQLVSYGLDSQREAISYARLN 260
            ::..|...::.|.|..||:||....:.|..::|.:||:|||:.|:.|:..|..:||||:.||: |
  Rat   156 ELNRILEALKVRVLRPALEWAVSNREMLIAQNSSLEFKLHRLYFISLLMGGTTNQREALQYAK-N 219

  Fly   261 FKKFAVRYEHEIANLMASFIYLPSGLENSPYKHFLGQEKWTELSFIFLKDACQLLGISKNSALSV 325
            |:.||:.::.:|..||.|.:||..|:|||||.|.|...:|.::..||.:|||.|||:|..|.|||
  Rat   220 FQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDANQWADICDIFTRDACALLGLSVESPLSV 284

  Fly   326 VVNAGCTALPALLNIKQVMQSRQVLGMWNGCDELPIEIDLQPEFRFHSIFACPILRQQTSEDNPP 390
            ..:|||.|||||:|||.|::.||..|:||..||||||:||..:..:|||||||||||||:::|||
  Rat   285 SFSAGCVALPALINIKAVIEQRQCTGVWNQKDELPIEVDLGKKCWYHSIFACPILRQQTTDNNPP 349

  Fly   391 KKLTCGHVISNDALHKLSVGHILKCPYCPVEQNAEEAVRIYF 432
            .||.|||:||.|||:|:..|..|||||||:||:..:|.:|:|
  Rat   350 MKLVCGHIISRDALNKMFNGSKLKCPYCPMEQSPGDAKQIFF 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3295	NP_611536.1	COG5109	88..432	CDD:227440	158/347 (46%)
		LisH	152..181	CDD:128913	13/28 (46%)
		CTLH	193..250	CDD:128914	18/56 (32%)
		CRA	252..343	CDD:214806	47/90 (52%)
		zf-RING_UBOX	377..416	CDD:290181	25/38 (66%)
Rmnd5a	XP_038964634.1	COG5109	17..391	CDD:227440	169/417 (41%)
Rmnd5a	XP_038964634.1	CLTH	153..297	CDD:402305	63/144 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341838
Domainoid	1	1.000	123	1.000	Domainoid score	I5449
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5668
Inparanoid	1	1.050	313	1.000	Inparanoid score	I2499
OMA	1	1.010	-	-		QHG55101
OrthoDB	1	1.010	-	-		D576638at33208
OrthoFinder	1	1.000	-	-		FOG0002102
OrthoInspector	1	1.000	-	-		otm45806
orthoMCL	1	0.900	-	-		OOG6_102297
Panther	1	1.100	-	-	O	PTHR12170
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1554
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910