DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9346 and u2surp

DIOPT Version :9

Sequence 1:	NP_611535.1	Gene:	CG9346 / 37381	FlyBaseID:	FBgn0034572	Length:	957	Species:	Drosophila melanogaster
Sequence 2:	NP_001184003.1	Gene:	u2surp / 567461	ZFINID:	ZDB-GENE-070912-400	Length:	968	Species:	Danio rerio

Alignment Length:	1027	Identity:	451/1027 - (43%)
Similarity:	611/1027 - (59%)	Gaps:	149/1027 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AASATLKRISEKKLEAFTVG--TFSKRQLSKKELEDQKKKEDAAAAAHAFKEFVETFQDAPTPSS 75
            |.....|.:.|.||:||::|  ..:||.|||||.::.|||||..|||..::||:..|:.. ....
Zfish     9 AQKGNSKALLESKLKAFSIGKMAVAKRTLSKKEQDEIKKKEDERAAAEIYEEFLAAFEGG-EGKV 72

  Fly    76 KVWVKAGTYDAGSRREDKS---EKGKLYKPVSKLMEKSSSDKVEDYAKTLASDLKKDSGPLKKKN 137
            |.:|:.|.  |.:.:|:.:   :|||||||.|:::|..|...:|...:.|..|.:..|   ||.:
Zfish    73 KTFVRGGI--ANATKEEAAADEKKGKLYKPKSRIVEAKSFLPLETPQQFLPIDKRNAS---KKGD 132

  Fly   138 QEKKKSNLELFKEELRQIQEEREERHKYKHMASSHSAPAQQPAASAAPVPS-----SSVSTTSQN 197
            :||||||||||||||:||||||:|||:.|...|...           |:|:     ||..::.:|
Zfish   133 KEKKKSNLELFKEELKQIQEERDERHRLKGRVSRFE-----------PLPTTEGRRSSDGSSRRN 186

  Fly   198 SSSS----KESGSFDTGDPNTTNLYLGNLNPKISEQQLMEIFGRYGPLASIKIMWPRSEEEKQRG 258
            ..||    ...||.|.|||.||||||||:||:::|:.|.:.|||||||||:||||||::||:.|.
Zfish   187 RPSSVLDDSAPGSHDVGDPTTTNLYLGNINPQMNEEMLCQEFGRYGPLASVKIMWPRTDEERARE 251

  Fly   259 RNCGFVAYMSRKDAERALKTLNGRYIMGYEMRLGWGKTVPIMNTPIFTPQALLEMTLPPPPSGLP 323
            |||||||:|:|:|||||||.|||:.||.:||:|||||.|||...||:.|.:::|.||||||||||
Zfish   252 RNCGFVAFMTRRDAERALKHLNGKMIMNFEMKLGWGKGVPIPPHPIYIPPSMMEHTLPPPPSGLP 316

  Fly   324 FNAQPP-----PSEADVLPKKNYKEFNQEDKENMERILAKCVVKVHIPTEKAVLNVIHRMIEFVI 383
            |||||.     |:.|...|.|        .||..|:.|::.:|||.||||:.:|::||||||||:
Zfish   317 FNAQPKERLKNPNAAMPPPPK--------CKEEFEKTLSQAIVKVVIPTERNLLSLIHRMIEFVV 373

  Fly   384 REGPMFEALIMIREMENPLFAFLFDNESPAHIYYRWKLFSLLQGDTPNEWREEEFRMFKNGPVWK 448
            ||||||||:||.||:.|||:.|||:|:||||:||||||:::|||::|.:|:.|:|||||||.:|:
Zfish   374 REGPMFEAMIMNREINNPLYRFLFENQSPAHVYYRWKLYTILQGESPTKWKTEDFRMFKNGSLWR 438

  Fly   449 PPIANFYTQGMP--DELVVDPDAPVVHKGALSNAQRNRLEDLIRHLTPERARIGDAMIFCIEHAD 511
            ||..|.|..|.|  :|...|.|..:..||:|.:.:|::||:|:|.|||.::.|...|.||:.|||
Zfish   439 PPPLNPYLHGTPEDEEHEDDDDEEICKKGSLKDEERDKLEELLRGLTPRKSDIAGGMFFCLTHAD 503

  Fly   512 AADEICECIAESLSNINTLASKKIARLYLISDILHNCTVKVANASFFRKSVEKQLLDIFDNLHNY 576
            ||:||.||||||||.:.|...||||||||:||:|:|.:.||.|||::||..|.:|..||.:|:..
Zfish   504 AAEEIVECIAESLSILKTPLPKKIARLYLVSDVLYNSSAKVTNASYYRKFFETKLCQIFSDLNAT 568

  Fly   577 YLNIESRLKAEGFKSRVCNVIRTWEEWTIYPKDFMAQLTAKFLG----KPYVKPVNNSPQAEETR 637
            |..|:..|::|.||.||.:..|.||||.:||..|:.:|...|||    .|..:|....|:..|.
Zfish   569 YKTIQGHLQSENFKQRVMSCFRAWEEWAVYPDPFLIKLQNIFLGLVSLDPEKEPEELVPELPEK- 632

  Fly   638 FDEALDEDIDGAPLSGEEKDD---EDLDGVPLDGAALLKSALKRAIPDADAGTPKRDTPKKDEYL 699
                 .|||||||:..||.|.   :|:||:|:|||                       |.....:
Zfish   633 -----VEDIDGAPIVEEELDGAPLDDVDGMPIDGA-----------------------PIDGASM 669

  Fly   700 DEIDGIPL---DDDLDGVPLEKETKSTAKLPGF--IPSKWETVDPQQVEAQAITTSKWDTLDPPD 759
            |::||:|:   |||||||||:::       |||  .|||||.||...:||||:|||||:..|.|:
Zfish   670 DDLDGMPIKGADDDLDGVPLDQK-------PGFKVAPSKWEAVDGAALEAQAVTTSKWEIFDLPE 727

  Fly   760 PP-----------------KFFSSDDDSGEDNP--QKY----------TDEMRQKLRDIESKAIQ 795
            ..                 |..|:.|.....||  ::|          ::|.|.|||:||.|.::
Zfish   728 ESEKSKSSTKSEAEGKNSHKSSSAADQQSYSNPVREEYDLKSAKFSETSEEKRAKLREIELKVMK 792

  Fly   796 YQDELESGKRRLEPGWSVPEQVEQFRKRLLKQDSRSEATVDSPLSYMHIKSKSSKVSESPALFRS 860
            :|||||||||..:.|.|:.||||.:|.:||:::...|...|....    |.|..|..|...:|..
Zfish   793 FQDELESGKRPKKSGQSIQEQVELYRDKLLQREKEKETEKDKEKE----KEKERKDKEKSDVFHK 853

  Fly   861 SSRKRSHSPFSGGESKRRDYSPETSRS-SKSSKRNRSRSPSS--SPKRYTERSSRSSRYETP--- 919
            ...|...:|  |.:.|:|.:||..|.: |.||:|.||.||.|  |.:.||..||||:..::|
Zfish   854 EKDKDESTP--GRKEKKRRHSPSPSPTRSSSSRRGRSPSPRSERSDRSYTRDSSRSAYKDSPRES 916

  Fly   920 -ASGSSRSRSSPTSSRSSRREEPSPPR-------------HRSDKHKHKHRH 957
             ...|.||.|.|.:.:.|||.....|:             |||.|...|.:|
Zfish   917 NRKSSKRSPSPPRTPKRSRRSRSRTPKKASKKSRSRSRSPHRSHKKSKKSKH 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9346	NP_611535.1	RRM_SR140	214..297	CDD:240669	58/82 (71%)
		Surp	373..423	CDD:280053	37/49 (76%)
		RPR	480..619	CDD:214731	69/138 (50%)
		cwf21	784..827	CDD:285507	24/42 (57%)
u2surp	NP_001184003.1	RRM_SR140	207..290	CDD:240669	58/82 (71%)
		Surp	364..412	CDD:280053	36/47 (77%)
		VHS_ENTH_ANTH	476..611	CDD:295355	68/134 (51%)
		cwf21	782..823	CDD:285507	23/40 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575693
Domainoid	1	1.000	280	1.000	Domainoid score	I1645
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13964
Inparanoid	1	1.050	755	1.000	Inparanoid score	I536
OMA	1	1.010	-	-		QHG46489
OrthoDB	1	1.010	-	-		D280924at33208
OrthoFinder	1	1.000	-	-		FOG0004033
OrthoInspector	1	1.000	-	-		otm25751
orthoMCL	1	0.900	-	-		OOG6_102628
Panther	1	1.100	-	-	LDO	PTHR23140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4207
SonicParanoid	1	1.000	-	-		X3308
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940