DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9346 and U2SURP

DIOPT Version :9

Sequence 1:	NP_611535.1	Gene:	CG9346 / 37381	FlyBaseID:	FBgn0034572	Length:	957	Species:	Drosophila melanogaster
Sequence 2:	NP_001073884.1	Gene:	U2SURP / 23350	HGNCID:	30855	Length:	1029	Species:	Homo sapiens

Alignment Length:	1039	Identity:	458/1039 - (44%)
Similarity:	618/1039 - (59%)	Gaps:	144/1039 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KQGNKSKDSAAAS------ATLKR-ISEKKLEAFTVGTFS--KRQLSKKELEDQKKKEDAAAAAH 58
            ::.|...:||..|      ..|.| :.|.||:||::|..|  ||.|||||.|:.|||||..|||.
Human    51 RKHNYRNESARESLCDSPHQNLSRPLLENKLKAFSIGKMSTAKRTLSKKEQEELKKKEDEKAAAE 115

  Fly    59 AFKEFVETFQDAPTPSSKVWVKAGTYDAGSRREDKSEK-GKLYKPVSKLME------KSSSDKVE 116
            .::||:..|:.:.....|.:|:.|..:|.....:..|| ||:|||.|:..:      :||:::.
Human   116 IYEEFLAAFEGSDGNKVKTFVRGGVVNAAKEEHETDEKRGKIYKPSSRFADQKNPPNQSSNERP- 179

  Fly   117 DYAKTLASDLKKDSGPLKKKNQEKKKSNLELFKEELRQIQEEREERHKYKHMASSHSAPAQQPAA 181
              ...|..:.||.  ||||..:||||||||||||||:||||||:||||.|...|....|......
Human   180 --PSLLVIETKKP--PLKKGEKEKKKSNLELFKEELKQIQEERDERHKTKGRLSRFEPPQSDSDG 240

  Fly   182 SAAPVPSSSVSTTSQNSSSSKESGSFDTGDPNTTNLYLGNLNPKISEQQLMEIFGRYGPLASIKI 246
            ....:.:.|....|.........||.|.|||:||||||||:||:::|:.|.:.|||:|||||:||
Human   241 QRRSMDAPSRRNRSSGVLDDYAPGSHDVGDPSTTNLYLGNINPQMNEEMLCQEFGRFGPLASVKI 305

  Fly   247 MWPRSEEEKQRGRNCGFVAYMSRKDAERALKTLNGRYIMGYEMRLGWGKTVPIMNTPIFTPQALL 311
            ||||::||:.|.|||||||:|:|:|||||||.|||:.||.:||:|||||.|||...||:.|.:::
Human   306 MWPRTDEERARERNCGFVAFMNRRDAERALKNLNGKMIMSFEMKLGWGKAVPIPPHPIYIPPSMM 370

  Fly   312 EMTLPPPPSGLPFNAQP-----PPSEADVLPKKNYKEFNQEDKENMERILAKCVVKVHIPTEKAV 371
            |.|||||||||||||||     .|:...:.|.||        ||:.|:.|::.:|||.||||:.:
Human   371 EHTLPPPPSGLPFNAQPRERLKNPNAPMLPPPKN--------KEDFEKTLSQAIVKVVIPTERNL 427

  Fly   372 LNVIHRMIEFVIREGPMFEALIMIREMENPLFAFLFDNESPAHIYYRWKLFSLLQGDTPNEWREE 436
            |.:||||||||:||||||||:||.||:.||:|.|||:|::|||:||||||:|:||||:|.:||.|
Human   428 LALIHRMIEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSILQGDSPTKWRTE 492

  Fly   437 EFRMFKNGPVWKPPIANFYTQGMPDE-----LVVDPDAPVVHKGALSNAQRNRLEDLIRHLTPER 496
            :|||||||..|:||..|.|..||.:|     .|.:|.    .||||...||::||:::|.|||.:
Human   493 DFRMFKNGSFWRPPPLNPYLHGMSEEQETEAFVEEPS----KKGALKEEQRDKLEEILRGLTPRK 553

  Fly   497 ARIGDAMIFCIEHADAADEICECIAESLSNINTLASKKIARLYLISDILHNCTVKVANASFFRKS 561
            ..|||||:||:.:|:||:||.:||.||||.:.|...||||||||:||:|:|.:.||||||::||.
Human   554 NDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASYYRKF 618

  Fly   562 VEKQLLDIFDNLHNYYLNIESRLKAEGFKSRVCNVIRTWEEWTIYPKDFMAQLTAKFLGKPYVKP 626
            .|.:|..||.:|:..|..|:..|::|.||.||....|.||:|.|||:.|:.:|...|||
Human   619 FETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLG------ 677

  Fly   627 VNNSPQAEETRFDEALDEDIDGAPLSGEEKDDEDLDGVPLDGAALLKSALKRAIPDADAGTPKRD 691
            :.|..:.:||   |.:.:|:||||:      :|:|||.||:              |.| |.|...
Human   678 LVNIIEEKET---EDVPDDLDGAPI------EEELDGAPLE--------------DVD-GIPIDA 718

  Fly   692 TPKKDEYLDEIDGIP---LDDDLDGVPLEKETKSTAKLPGF--IPSKWETVDPQQVEAQAITTSK 751
            ||     :|::||:|   ||||||||||:....|....|.|  .|||||.||..::||||:||||
Human   719 TP-----IDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSK 778

  Fly   752 WDTLDPPD--PPKFFSSDDDSGED----------------NP----------QKY---TDEMRQK 785
            |:..|..:  ..:...:.::..||                ||          .||   ::|.|.|
Human   779 WELFDQHEESEEEENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAK 843

  Fly   786 LRDIESKAIQYQDELESGKRRLEPGWSVPEQVEQFRKRLL--------------------KQDSR 830
            ||:||.|.:::|||||||||..:||.|..||||.:|.:||                    |.:||
Human   844 LREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQREKEKELERERERDKKDKEKLESR 908

  Fly   831 SEATVDSPLSYMHIKSKSSKVSESPALFRSSSRKRSHSPFSGGESKRRDYSPETSRSSKSSKRNR 895
            |:...:........|.:..:.|.||:..||||.:|..||     |.:.:.|..:.||.|.|.|:|
Human   909 SKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSP-----SPKSERSERSERSHKESSRSR 968

  Fly   896 SRSPSSSPKRYTERSSRS-SRYETP-ASGSSRSRSSPTSSRSSRREEPSPPRHRSDKHKHKHRH 957
            | |...||:..::::.|| |...|| .|..|||||...|.:.||.:..||  |||.|...|::|
Human   969 S-SHKDSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSP--HRSHKKSKKNKH 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9346	NP_611535.1	RRM_SR140	214..297	CDD:240669	57/82 (70%)
		Surp	373..423	CDD:280053	36/49 (73%)
		RPR	480..619	CDD:214731	69/138 (50%)
		cwf21	784..827	CDD:285507	25/62 (40%)
U2SURP	NP_001073884.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..111		26/59 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..274		53/137 (39%)
		RRM	156..>352	CDD:223796	102/200 (51%)
		RRM_SR140	273..356	CDD:409670	57/82 (70%)
		Surp	429..480	CDD:396395	36/50 (72%)
		SURP motif	430..473		30/42 (71%)
		RPR	541..676	CDD:214731	67/134 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..841		10/62 (16%)
		cwf21_SR140	836..884	CDD:410597	26/47 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..1029		67/181 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142857
Domainoid	1	1.000	277	1.000	Domainoid score	I1731
eggNOG	1	0.900	-	-		E1_KOG0151
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13964
Inparanoid	1	1.050	754	1.000	Inparanoid score	I569
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46489
OrthoDB	1	1.010	-	-		D280924at33208
OrthoFinder	1	1.000	-	-		FOG0004033
OrthoInspector	1	1.000	-	-		oto88663
orthoMCL	1	0.900	-	-		OOG6_102628
Panther	1	1.100	-	-	LDO	PTHR23140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4207
SonicParanoid	1	1.000	-	-		X3308
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800