DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KCNA3 and Shab

DIOPT Version :9

Sequence 1:	NP_002223.3	Gene:	KCNA3 / 3738	HGNCID:	6221	Length:	575	Species:	Homo sapiens
Sequence 2:	NP_001189037.1	Gene:	Shab / 38352	FlyBaseID:	FBgn0262593	Length:	1607	Species:	Drosophila melanogaster

Alignment Length:	680	Identity:	199/680 - (29%)
Similarity:	296/680 - (43%)	Gaps:	179/680 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    26 PASSGGAHTLVNHGYAEPA--AGRELPPDMTVVPGDHLLEPEV-----ADGGGAPPQGGCG---- 79
            ||:.|.|:.|   |.|.||  ..|.|    ....|.||..|..     |.|.||....|.|
  Fly   142 PAAGGAAYHL---GPANPAGLVSRHL----DYGDGGHLAGPSAGLPAGAVGSGAGAGAGAGASVT 199

Human    80 --GGGCD--------------------RYEPLPPSLP---------------------AAGEQDC 101
              |.|..                    ||.|.|.:.|                     .|..|..
  Fly   200 GSGSGAGTGTGTGAGSGSGSGAAGKEVRYAPFPVASPTHSIPTTSQQIVGSVGGVGVGGASSQSI 264

Human   102 CG----------------------------------------ERVVINISGLRFETQLKTLCQFP 126
            .|                                        .||.||:.|:|.|...:||.:.|
  Fly   265 SGGVPTHSQSNTTGALQRTHSRSMSSIPPPEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLP 329

Human   127 ETLLGDPKRRMRY-------------FDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPID 178
            .|.||    |:|.             :....|||||||:..||.:||.:|:: |::.....:.:.
  Fly   330 HTRLG----RLRECTTHEAIVELCDDYSLADNEYFFDRHPKSFSSILNFYRT-GKLHIVDEMCVL 389

Human   179 IFSEEIRFYQLGE------------EAMEKFREDEGFLREEERPLPRRD-----------FQRQV 220
            .||:::.::.:.|            :..|...|:   :|:|...|.:||           :|:.:
  Fly   390 AFSDDLEYWGVDELYLESCCQHKYHQRKENVHEE---MRKEAESLRQRDEEEFGEGKCAEYQKYL 451

Human   221 WLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSR 285
            |.|.|.|.:|..||.||::|:|.|::|.:...|.|||:.:...:   .|.||:.:.|
  Fly   452 WELLEKPNTSFAARVIAVISILFIVLSTIALTLNTLPQLQHIDN---GTPQDNPQLA-------- 505

Human   286 AGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAER 350
                       :||.:||.||:.|.::||.|.|.|..|.:..:|:||::||:|||::|......:
  Fly   506 -----------MVEAVCITWFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSLFLLETNK 559

Human   351 QGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSA 415
            ....|......:::|.|::|:.||.||:|||.|||.||.||:.|.:|||||:.||.:||::|||.
  Fly   560 NATDQFQDVRRVVQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSL 624

Human   416 VYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIV 480
            .||||.|:..:.|.|||:.||||.:|||||||||::|.|..||::|::|.|.|||.||||:|:||
  Fly   625 AYFAEKDEKDTKFVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIV 689

Human   481 SNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQT 545
            :||..||..:...|:..:            ..|.|.:|:...::....::.:::...........
  Fly   690 NNFAEFYKNQMRREKALK------------RREALDRAKREGSIVSFHHINLKDAFAKSMDLIDV 742

Human   546 PFKTGNSTATCTTNNNPNSCVNIKKIFTDV 575
            ...||..|..........|..||.:...||
  Fly   743 IVDTGKQTNVVHPKGKRQSTPNIGRQTLDV 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KCNA3	NP_002223.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		11/27 (41%)
		BTB	106..200	CDD:197585	31/118 (26%)
		BTB_2	106..197	CDD:280393	31/115 (27%)
		Ion_trans	290..490	CDD:278921	96/199 (48%)
		Ion_trans_2	404..481	CDD:285168	45/76 (59%)
		Selectivity filter. /evidence=ECO:0000250	444..449		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250	573..575		0/1 (0%)
Shab	NP_001189037.1	BTB	309..416	CDD:197585	30/111 (27%)
		BTB_2	309..408	CDD:280393	30/103 (29%)
		Ion_trans	501..700	CDD:278921	97/217 (45%)
		Ion_trans_2	613..696	CDD:285168	48/82 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810