DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10543 and zbtb11

DIOPT Version :9

Sequence 1:	NP_001369100.1	Gene:	CG10543 / 37379	FlyBaseID:	FBgn0034570	Length:	1666	Species:	Drosophila melanogaster
Sequence 2:	XP_012813021.2	Gene:	zbtb11 / 734142	XenbaseID:	XB-GENE-988913	Length:	1117	Species:	Xenopus tropicalis

Alignment Length:	1177	Identity:	228/1177 - (19%)
Similarity:	387/1177 - (32%)	Gaps:	351/1177 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SHIAAANDNGESGGRAQQ-HELARTKQLQLLLTAKKEKKELGIGCEAEIKRENDEEEAGSTDLNQ 120
            :||..   .||...|.|. |.|::|...:.:|...|:..:....|:     |..:....:.|.::
Frog    78 AHIGT---GGEHLTRHQTWHVLSQTYWWRGILKHMKDYIKDCSKCQ-----ERTDRSRSTNDASE 134

  Fly   121 NFEKIPCKEEFLCLEEEEEDFLDDADTQNSSSLQFHTGNNVDALALGPGDPLELIQSGVSLLVKR 185
            ..|:       |.|:...:....|.::.|.:|..:.|....                       |
Frog   135 MLEE-------LGLDVRSDTNETDDESSNPASNTYQTPKPA-----------------------R 169

  Fly   186 KYAATFDDELIGDGDGDEANSNSSDGKMV----KRKRTNNMHLTVSSVRRKEE---HGQLGDGYV 243
            |......:.:..|..|....|:|..|:.:    .::|.||....|:.:...:|   |..     |
Frog   170 KKPTAKHELVFVDSKGIVKQSSSKHGQTILDQLNQQRLNNQFCDVTLLIEGQEFKAHKA-----V 229

  Fly   244 FHEDSQYTMRYHHSTGEF-SERAF-------KAQFRALLRLA-----------------LSQH-- 281
            ....|:|........|.. |..||       |:.|..||..|                 |::|
Frog   230 LAASSEYFRELFIEKGAVSSHEAFVDLSGFCKSSFLPLLEFAYTSELVFDFCSMAEISMLARHLF 294

  Fly   282 -----------HKPF------LRQFYENFVVNGRLLGTTPSMRVLKELREQRLEEWRRQRERRQL 329
                       ||..      |.|..:....||.|.|....::.:.....|.|.|
Frog   295 MNEVLEICESVHKQMETNQINLCQKVDVVSENGLLDGRVVKLQAVGNNAPQLLAE---------- 349

  Fly   330 VILMEQSETQRDEEFQQQ---QELVENQEE--VQQEQEQQQQQ-------------------LED 370
            ||..:::....:|..:.:   .|.|.|..:  :.|..|:...|                   |.|
Frog   350 VINSQKTSLVNNENVECEAAATETVTNSTDGAISQSSEESTVQLVTSPEIPISSLTGTTAIYLSD 414

  Fly   371 IQQQ-----------HLEEIQRQQQLPAISFGDSELESET----ESQLSSAAQEIMKFEEFI--- 417
            :..:           .:..:|..||:    .||:..:|.|    |||.|:|...:...:|.:
Frog   415 VSSELQPAVIIPAVIDVSNVQEHQQI----LGDTPEDSTTAEHPESQQSTAGSNMDVPDEVLSVT 475

  Fly   418 ----DEGVGAGRLIDGLEMEPEIDDMLAGAGSMNSASGHSSNSSSSGSGSAGNGNGISGVILENN 478
                :|.:.|.        :|:..|:     ||......|:|.....|......:.||.:.||
Frog   476 CTTTEEKLPAD--------DPQPKDV-----SMKELINSSTNGDPQVSVPVAEESSISVIDLE-- 525

  Fly   479 SHHTHHLSSSSSANLVINGLTSSNSISNNNNNSNNVSLHRPQLTPQAQNQLAASMKPSDHIPISM 543
                     ::.|..|:.|.|.                      |..:.::....|.....|...
Frog   526 ---------TTCAEDVVIGNTD----------------------PDPEAKIGEVPKRKRGRPRKS 559

  Fly   544 PMENMDLKAGQAAHGTANAIMQGGSSSLASQLHQ--------------QQKPYNSSN-NPLSMMG 593
            | |:::    ::...|...:..||..:...:|..              |:|...... ||.|.:
Frog   560 P-EDVE----KSCKETRETLPSGGKCTYKGKLRDCLVGKGGYIMLHRGQEKALKKRKANPKSAV- 618

  Fly   594 GMMQQQQQQHVAMPHHQRQMMMMPE------DFPQHGASMMNSRQMPALAALSNLGDTPAMSGQL 652
                 ||.....:...:::.:|:|:      .|..:...||..|:.    ||.........|.:.
Frog   619 -----QQAAMKLLQRGKKKRLMVPKKQIAEAQFKCNDCGMMFQRRY----ALIMHSVKHEKSKEF 674

  Fly   653 NSSLELDDNDLSADEDDDDLDHDLDELDAAKQQLIDGGSSSSTSLQAPPSQHGSGSGGSGGQTPG 717
            ...|...:....|               :.:..||....:....:....::..:..||:
Frog   675 KCPLCTKEFQYRA---------------SLRAHLIRHSKTGKAEVNVVETEADTAKGGT------ 718

  Fly   718 SKKDKPSYNCLLC----PKSYRKRKSLLDHYKMHPGYCHDCGQ----RNGNTLEEIIHH------ 768
                |..:.|.:|    ||.|..|..:|.|..:.|..|..||:    ::|..:.:.:|.
Frog   719 ----KRQFICGICGRTLPKLYSLRIHMLKHTGVKPHACEVCGKTFTHKHGLKMHQALHESHKQFK 779

  Fly   769 ----------NRTM------HVKEFPFVCETCGESYSRKQQFHAHVESHNKK-EIKTFPCGECGL 816
                      ||::      |..|..::|..||:::.|......|::.|..| |.:.:.|.:|..
Frog   780 CDMCEKSFVTNRSLQEHVSTHTGESKYLCSVCGKAFHRASGLSKHLKKHKPKVETRGYHCTQCEK 844

  Fly   817 KFPQ-KKLQQH---------FEETGHKADGAICEVCGEEFQSKNALYQHIIRVHKRDNFFECHIC 871
            .|.: :.||||         ||          ||.||:.:..|...|.| ::.|.....:.|.:|
Frog   845 SFFELRDLQQHMNKHLGVKPFE----------CEFCGKCYSWKKDWYSH-VKSHSVTEPYRCSVC 898

  Fly   872 HNRFTLKANLERHVQLHTEIKR-------PYVCDLCGSSYFTYPALKEHYSNAHVDVSECKCTLC 929
            ...|..||...|||...|..|:       ...|:.||..:..:...:.|.:| |..|...:|..|
Frog   899 GKEFYEKALYRRHVNKATHGKKGRTKLNFEKACEHCGKIFTQFREYRRHVNN-HEGVKPFECLTC 962

  Fly   930 GKRFGSAKSLQRHLPSHSEERPHCCNYCDQTFKWKTHLVRHKQTMHGNEPPPPKKGKQRFPKTS- 993
            |..:..|:||:||:.:|:.|||:.|..|::.:.....|.:|....|.:..|    ||....|.|
Frog   963 GVAWADARSLKRHVRTHTGERPYVCPVCNEGYIDARTLRKHMTKTHKDYVP----GKIMLEKDSL 1023

  Fly   994 ---------EEDMGSL-PDMPGPPPVKASKKAAT----SKAKAQAAAAAAAAASSQQ-------- 1036
                     |..:..| .|:..|.....:::..|    .:|.||...:.|.::.|.|
Frog  1024 QFHNQGTQVEHAVSILSTDLDEPQAEIVTEEIETVVVAEEAMAQTPNSTAVSSLSDQSIMQVVNY 1088

  Fly  1037 --QQQKG 1041
              .||:|
Frog  1089 VLSQQQG 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10543	NP_001369100.1	C2H2 Zn finger	727..747	CDD:275368	8/23 (35%)
		C2H2 Zn finger	751..773	CDD:275368	7/47 (15%)
		C2H2 Zn finger	781..801	CDD:275368	5/19 (26%)
		PHA00733	<804..860	CDD:177301	18/66 (27%)
		C2H2 Zn finger	811..827	CDD:275368	7/25 (28%)
		C2H2 Zn finger	839..860	CDD:275368	7/20 (35%)
		C2H2 Zn finger	868..888	CDD:275368	8/19 (42%)
		C2H2 Zn finger	897..913	CDD:275368	3/15 (20%)
		C2H2 Zn finger	926..946	CDD:275368	8/19 (42%)
		C2H2 Zn finger	954..975	CDD:275368	4/20 (20%)
zbtb11	XP_012813021.2	Integrase_H2C2	68..122	CDD:407771	12/51 (24%)
		BTB_POZ_ZBTB11	193..310	CDD:349511	23/121 (19%)
		C2H2 Zn finger	648..668	CDD:275370	5/23 (22%)
		C2H2 Zn finger	676..696	CDD:275368	4/34 (12%)
		C2H2 Zn finger	724..744	CDD:275368	7/19 (37%)
		SFP1	<741..826	CDD:227516	17/84 (20%)
		C2H2 Zn finger	752..772	CDD:275368	4/19 (21%)
		C2H2 Zn finger	780..800	CDD:275368	2/19 (11%)
		C2H2 Zn finger	808..828	CDD:275368	5/19 (26%)
		C2H2 Zn finger	839..859	CDD:275368	7/19 (37%)
		zf-H2C2_2	851..875	CDD:404364	10/33 (30%)
		C2H2 Zn finger	867..887	CDD:275368	7/20 (35%)
		C2H2 Zn finger	895..917	CDD:275370	8/21 (38%)
		C2H2 Zn finger	931..951	CDD:275368	5/20 (25%)
		C2H2 Zn finger	959..979	CDD:275368	8/19 (42%)
		zf-H2C2_2	971..>990	CDD:404364	9/18 (50%)
		C2H2 Zn finger	987..1008	CDD:275368	4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100