DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10543 and ZFAT

DIOPT Version :9

Sequence 1:	NP_001369100.1	Gene:	CG10543 / 37379	FlyBaseID:	FBgn0034570	Length:	1666	Species:	Drosophila melanogaster
Sequence 2:	NP_065914.2	Gene:	ZFAT / 57623	HGNCID:	19899	Length:	1243	Species:	Homo sapiens

Alignment Length:	1326	Identity:	239/1326 - (18%)
Similarity:	448/1326 - (33%)	Gaps:	371/1326 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QFLLQTLKCKYPESC-------DQVVRNLFSHIAAANDNGESGGRAQQHELARTKQLQLLLTAKK 91
            :||:...|...|:..       :::..|:.|....:....|.|.......|..:|..:.....::
Human    66 EFLVMKRKRGRPKGSTKKSSTEEELAENIVSPTEDSPLAPEEGNSLPPSSLECSKCCRKFSNTRQ 130

  Fly    92 EKKELGIGCEAEIKRENDEEEAGS-TDLNQNFEKIPCKEEFLCLEEEEEDFLDDADTQNSSSLQF 155
            .:|.:   |...:....:|.|||: :||  ..||       .|.|::.|.......:|.:..:|.
Human   131 LRKHI---CIIVLNLGEEEGEAGNESDL--ELEK-------KCKEDDREKASKRPRSQKTEKVQK 183

  Fly   156 HTGNNVDALALGPGDPLELIQSGVSLLVKRKYAATFDDELI----GDGDGDEANSNSSDGKMVKR 216
            .:|.....|: |...|:      :|:::....|.....:::    |..:....||.::...:|.|
Human   184 ISGKEARQLS-GAKKPI------ISVVLTAHEAIPGATKIVPVEAGPPETGATNSETTSADLVPR 241

  Fly   217 KRTNNMHLTVSSVRRKEEHGQLGDG-------------YVFHEDSQYTMRYHHSTGEFS--ERAF 266
            :......:..:...:..:..:||..             :.|....|..:|.|.:...:.  :.::
Human   242 RGYQEYAIQQTPYEQPMKSSRLGPTQLKIFTCEYCNKVFKFKHSLQAHLRIHTNEKPYKCPQCSY 306

  Fly   267 KAQFRALLRLALSQHHKPFLRQFYENF--VVNGRLLGTTPSMRVLKELREQRLEEWRRQRERRQL 329
            .:..:|.|.:.|.:|........|.:|  :..|.|  .....||.|::::......::..:.:.|
Human   307 ASAIKANLNVHLRKHTGEKFACDYCSFTCLSKGHL--KVHIERVHKKIKQHCRFCKKKYSDVKNL 369

  Fly   330 VILMEQSETQRDEEFQQQQELVENQEEV-QQEQEQQQQQLED---IQQQHLEEIQRQQQLPAISF 390
            :      :..||....|.:::.|..:|: ...:|.::|.|.|   .:::...|:.|.:.:  :..
Human   370 I------KHIRDAHDPQDKKVKEALDELCLMTREGKRQLLYDCHICERKFKNELDRDRHM--LVH 426

  Fly   391 GD----------------------------------------SELESETE-SQLSSAAQEIMKF- 413
            ||                                        |.:...|. .::..||||.:.|
Human   427 GDKWPFACELCGHGATKYQALELHVRKHPFVYVCAVCRKKFVSSIRLRTHIKEVHGAAQEALVFT 491

  Fly   414 -----------------------------EEFIDEGV---------GAGRLIDGLEMEPEIDDML 440
                                         |||..:||         |..:|.:| ..|||
Human   492 SSINQSFCLLEPGGDIQQEALGDQLQLVEEEFALQGVNALKEEACPGDTQLEEG-RKEPE----- 550

  Fly   441 AGAGSMNSASGHSSNSSSSGSGSAGNGNGISGVILENNSHHTHHLSSSSSANLVINGLTSSNSIS 505
             ..|.|.:.:.|.::..:..:.            |......|..:|||.        |.|...:|
Human   551 -APGEMPAPAVHLASPQAESTA------------LPPCELETTVVSSSD--------LHSQEVVS 594

  Fly   506 NN---NNNSNNVSLH-RPQLTPQAQNQLAASMKPSDHIPISMPMENMDLKAGQAAHGTANAIMQG 566
            ::   .|::::...| .|:..|..|::  :|::....:...:..:.....:.|.:||..:.:.:|
Human   595 DDFLLKNDTSSAEAHAAPEKPPDMQHR--SSVQTQGEVITLLLSKAQSAGSDQESHGAQSPLGEG 657

  Fly   567 GSSSLAS------QLHQQQKPYNSSN--NPLSMMGGMMQQQQQQHVAMPHHQRQMMMMPEDFPQH 623
            .:.::.|      ....:..|..:|:  .|::..|..:..|.....|.|.|:..:...
Human   658 QNMAVLSAGDPDPSRCLRSNPAEASDLLPPVAGGGDTITHQPDSCKAAPEHRSGITAF------- 715

  Fly   624 GASMMNSRQMPALAALSNLGDTPAMSGQLNSSL----ELDDNDLSADE-----------DDDDLD 673
             ..::||.|                ..|:|:||    .....||..:.           |.....
Human   716 -MKVLNSLQ----------------KKQMNTSLCERIRKVYGDLECEYCGKLFWYQVHFDMHVRT 763

  Fly   674 HDLDEL-------------DAAKQQLIDGGSSSSTSLQAPPSQHGSGSGGSGGQTPGSKK----- 720
            |..:.|             :..|:.:|.  ..|:..|:.|       :.|....||...|
Human   764 HTREHLYYCSQCHYSSITKNCLKRHVIQ--KHSNILLKCP-------TDGCDYSTPDKYKLQAHL 819

  Fly   721 ------DKPSYNCLLCPKSYRKRKSLLDHYKM-HPGYCHDCGQRNGNTLEEIIHHNRTMHVK--- 775
                  ||.||:|.:|.||:.:.:.:..|.|. ||       :.:.:|:.|::  .|.:.:|
Human   820 KVHTALDKRSYSCPVCEKSFSEDRLIKSHIKTNHP-------EVSMSTISEVL--GRRVQLKGLI 875

  Fly   776 -EFPFVCETCGESYSRK--QQFHAHVESHNKKEIKTFPCGECGLKFPQKK-----LQQHFEETGH 832
             :....|..| :.|..|  .....|:.:|  :.:|.|.|..|......|.     :.:|..|..|
Human   876 GKRAMKCPYC-DFYFMKNGSDLQRHIWAH--EGVKPFKCSLCEYATRSKSNLKAHMNRHSTEKTH 937

  Fly   833 KADGAICEVCGEEFQSKNALYQHIIRVHKRD-NFFECHICHNRFTLKANLERHVQLHTEIKRPYV 896
                 :|::||::|:||..|..|.: :|..| ..|:|.:|......|..|.||::.|...| |:.
Human   938 -----LCDMCGKKFKSKGTLKSHKL-LHTADGKQFKCTVCDYTAAQKPQLLRHMEQHVSFK-PFR 995

  Fly   897 CDLCGSSYFTYPALKEHYSNAH------------------VDVSECKCTLCGKRFGSAKSLQRHL 943
            |..|..|.....:||.||:..|                  :.....||.:|...:|:.....|||
Human   996 CAHCHYSCNISGSLKRHYNRKHPNEEYANVGTGELAAEVLIQQGGLKCPVCSFVYGTKWEFNRHL 1060

  Fly   944 PSHSEERPHCCNY--CDQTFKWKT-------------HLVRHKQTMHGNEPPPPKKGKQRFPKTS 993
                 :..|....  .|...||:|             |:...::.:.|.:.........|:  ||
Human  1061 -----KNKHGLKVVEIDGDPKWETATEAPEEPSTQYLHITEAEEDVQGTQAAVAALQDLRY--TS 1118

  Fly   994 EEDMGSLPDMPGPPPVKASKK-----AATSKAKAQAAAAAAAAASSQQQQQKGSAATPTPPPPVS 1053
            |..     |...|..|...::     |.|..|.|.|:..|.|                  |..|:
Human  1119 ESG-----DRLDPTAVNILQQIIELGAETHDATALASVVAMA------------------PGTVT 1160

  Fly  1054 TTPGCLQQDPF--NAAMVSSNSSQSSTASTSQHSVSTSES-----QQNSIYNQSFNAEKQQPGQQ 1111
            ......:::|.  :..|:.....|:|.....||.:..|..     :..::|.|         |.:
Human  1161 VVKQVTEEEPSSNHTVMIQETVQQASVELAEQHHLVVSSDDVEGIETVTVYTQ---------GGE 1216

  Fly  1112 QPQNTLHQQHPTPPPPQQQQQQQQQQ 1137
            ..:..::.|....|..:|..:|..|:
Human  1217 ASEFIVYVQEAMQPVEEQAVEQPAQE 1242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10543	NP_001369100.1	C2H2 Zn finger	727..747	CDD:275368	6/20 (30%)
		C2H2 Zn finger	751..773	CDD:275368	3/21 (14%)
		C2H2 Zn finger	781..801	CDD:275368	5/21 (24%)
		PHA00733	<804..860	CDD:177301	16/60 (27%)
		C2H2 Zn finger	811..827	CDD:275368	3/20 (15%)
		C2H2 Zn finger	839..860	CDD:275368	8/20 (40%)
		C2H2 Zn finger	868..888	CDD:275368	6/19 (32%)
		C2H2 Zn finger	897..913	CDD:275368	5/15 (33%)
		C2H2 Zn finger	926..946	CDD:275368	6/19 (32%)
		C2H2 Zn finger	954..975	CDD:275368	5/35 (14%)
ZFAT	NP_065914.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..116		8/49 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..189		13/50 (26%)
		COG5048	<267..426	CDD:227381	27/168 (16%)
		zf-C2H2	271..293	CDD:278523	3/21 (14%)
		C2H2 Zn finger	273..293	CDD:275368	3/19 (16%)
		zf-H2C2_2	285..307	CDD:290200	3/21 (14%)
		C2H2 Zn finger	301..321	CDD:275368	3/19 (16%)
		C2H2 Zn finger	328..349	CDD:275368	5/22 (23%)
		C2H2 Zn finger	356..377	CDD:275368	3/26 (12%)
		C2H2 Zn finger	406..426	CDD:275368	2/21 (10%)
		C2H2 Zn finger	434..454	CDD:275368	0/19 (0%)
		C2H2 Zn finger	460..478	CDD:275368	2/17 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	534..570		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..625		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..705		10/66 (15%)
		C2H2 Zn finger	744..764	CDD:275368	1/19 (5%)
		C2H2 Zn finger	772..822	CDD:275368	9/58 (16%)
		C2H2 Zn finger	832..851	CDD:275368	5/18 (28%)
		C2H2 Zn finger	882..903	CDD:275368	5/21 (24%)
		C2H2 Zn finger	911..931	CDD:275368	3/19 (16%)
		zf-H2C2_2	923..948	CDD:290200	7/29 (24%)
		C2H2 Zn finger	939..959	CDD:275368	8/20 (40%)
		C2H2 Zn finger	968..988	CDD:275368	6/19 (32%)
		C2H2 Zn finger	996..1017	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1043..1061	CDD:275368	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159360
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840