DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10543 and CG7987

DIOPT Version :9

Sequence 1:	NP_001369100.1	Gene:	CG10543 / 37379	FlyBaseID:	FBgn0034570	Length:	1666	Species:	Drosophila melanogaster
Sequence 2:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster

Alignment Length:	1340	Identity:	249/1340 - (18%)
Similarity:	422/1340 - (31%)	Gaps:	406/1340 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 EEEEEDFLDDADTQNSSSLQFHTGNNVDALA-------LGPGDPLELI---QSGVSLLVKR---- 185
            :..|.|.|:......:|      |.::|.:|       ...|...|::   ::|.::||..
  Fly    20 DSSEVDILESDGGAGAS------GEDLDHVAAENLIFMARDGQLSEIMAANEAGRTVLVTADGTT 78

  Fly   186 -KYAATFDDELIGDGDGDEANSNSSDGKMVKRKRTNNMHLTVSSVRRKEEHGQLGDGYVFHEDSQ 249
             .||.:|||      |.............|:.:....:.:....:.......:|.|    .|..:
  Fly    79 VAYAESFDD------DAQVVTEEVITDDWVQHQGAERVEIAAEQIAGISSSQELLD----MEQDE 133

  Fly   250 YTMRYHHSTGEFSERAFKAQFRALLRLALSQHHKPFLRQFYENFVVNGRLLGTTPSMRVLKELRE 314
            ||....:.. :|..|.|:.:......:...|:.:|.|          .:|.|...|.|.
  Fly   134 YTALRPYPC-DFCSRRFRKKATLNNHMLAHQNDRPHL----------CKLCGARFSRRA------ 181

  Fly   315 QRLEEWRRQRERRQLV-------------ILMEQSETQR---DEEFQQQQELVENQEEVQQEQEQ 363
            :.:..::...|.:...             .:..:.:|||   |..::|:..|.::    |||||.
  Fly   182 ELISHFKAHAEAQDAADAEAAAAAADSSSAIKFEHQTQRQLDDHYYEQEWPLFQH----QQEQEN 242

  Fly   364 QQQQLEDIQQQHLEEIQRQQQLPAISFGDSELESETESQLSSAAQEIMKFEEFIDEGVGAGRLID 428
            .||   ::.|||                                       :.::||
  Fly   243 AQQ---NVHQQH---------------------------------------QIVEEG-------- 257

  Fly   429 GLEMEPEIDDMLAGAGSMNSASGHSSNSSSSGSGSAGNGNGISGVILENNSHHTHHLSSSSSANL 493
            |:::.....|.:|                ...:.|.|..:.:..             ...||..:
  Fly   258 GIQLVASYPDTVA----------------QPAAPSRGRISRLKP-------------KEESSQFI 293

  Fly   494 VINGLTSSNSISNNNNNSNNVSLHRPQLTPQ-------AQNQLAASMKPSDHIPISMPMENMDLK 551
            ||    |..|:.::          ||.:.|:       ....:|....|..:.|:      :|
  Fly   294 VI----SDKSVEDS----------RPYMEPEPAQPVVTTSEFIAVEPPPQPNFPV------LD-- 336

  Fly   552 AGQAAHGTANAIMQGG-----SSSLASQL--HQQQKPYNSSNNPLSMMGGMMQQQQQQHVAMPHH 609
                 |.......|.|     ..:|.|..  |:...|:..:         ..|:....:.::..|
  Fly   337 -----HSKPFVCQQCGLAFAREKALVSHTKNHRVDSPFECN---------QCQEMFWDNSSLQEH 387

  Fly   610 QRQMMMMPEDFPQHGASMMNSRQMPALAALSNLGDTPAMSGQLNSSLELDDNDLSADEDDDDLDH 674
            |:          .|.....||...||.|..|  |.......||......::..:|....|....|
  Fly   388 QK----------THQFEESNSEYDPASAEES--GSESEADEQLYGEFYCNECGISFHRQDLLRRH 440

  Fly   675 DLDELDAAKQQLIDGGSSSSTSLQAPPSQH---GSGSGGSGGQTPGSKKDKPSYNCLLCPKSYRK 736
                                ..:...||..   ||.|..:.|......||...:.|..|.||:..
  Fly   441 --------------------AKMHCKPSDQAAVGSNSDVTAGGDVELAKDSSGHCCNTCGKSFPS 485

  Fly   737 RKSLLDHYKMH----PGYCHDCGQRNGNTLEE--IIHHNRTMHVKEF-PFVCETCGESYSRKQQF 794
            ...:|.|.::|    |..|..||.   :..||  |..|..|.|..|. ...|..||:....::..
  Fly   486 ALEMLAHAEIHARFPPFKCVLCGI---SFYEEQAIKRHLHTRHPSELNANSCVLCGKECRDRKAL 547

  Fly   795 HAHVESHNKKEIKTFPCGECGLKFPQK-KLQQHFEETGHKADGAICEVCGEEFQSKNALYQH--- 855
            ..|...|:::  |...|.:||..|..| :|::|.  ..|:....:||||.|||.....|..|
  Fly   548 IKHAWDHSRE--KCHSCSKCGKNFHNKARLKRHM--ASHRDKSVVCEVCQEEFPDGRTLSNHRHS 608

  Fly   856 ---------------------------IIRVHKRDNFFECHICHNRFTLKANLERHVQLHTEIKR 893
                                       .:|:|..:..:.|..|...|.....|.:|.::||. ::
  Fly   609 HSTTTPGKLFPCLECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTG-EK 672

  Fly   894 PYVCDLCGSSYFTYPALKEHYSNAH--VDVSE--CKCTLCGKRFGSAKSLQRHLPSHSEERPHCC 954
            ||.|.:|..::.....|:||..:.|  :||:.  ..||:|.:...|:..|.:||..||:.
  Fly   673 PYACSVCPRAFNQRVVLREHIRSHHSGLDVARNTYHCTVCSEDLASSNDLIQHLIQHSDS----- 732

  Fly   955 NYCDQ------------TFKWKTHLVRHKQT----MHGNEPPPPKKGKQR-------FPKTSEED 996
            |...|            ..|.:.|.:.|.:.    ::|:|.....:|...       |.....|:
  Fly   733 NTAKQRQPVTGPRKYKRRRKLQPHEIAHMRAANKHVNGDEEEAIGEGDAEECASDIDFCDFDVEN 797

  Fly   997 MGSLPDM-PGPPPVKASKKAATSKAKAQAAAAAAAA---------------ASSQQQQ------- 1038
            :..:.|| ..|...|..:.:|.:||.|:......||               .||||..
  Fly   798 VDDIFDMAESPKKEKRKRGSAATKADAKPVTNGKAAKPAQDKGKAKPRYDSTSSQQSDRLWEEKF 862

  Fly  1039 ----------------------QKGSAATPTPPPPVSTTPGCLQQDPFNAAMVSS----NSSQSS 1077
                                  |..|:|.....|  :|..|..||....|..|..    |||.::
  Fly   863 LHDSQVALFQIDSLVVVNDTHLQPASSAVSANIP--NTRGGSKQQGKVQAKSVEGAENLNSSATT 925

  Fly  1078 TASTSQHSVSTSESQQNSIYNQSFNAEKQQPGQQQPQNTLHQQHPTPPP----PQQQQQQQQQQQ 1138
            :.:|...|.||:.::.......:..|.|..|........:|.:......    .......::.:.
  Fly   926 SDTTFSASTSTASTRSRKRAATTKTASKAPPASNSRPRMIHTEKAKVTKGVGGDSTSSSAKKTRS 990

  Fly  1139 ALPQSRVGPGELHLQRMNSFGQDGQFHFESNPAAGAYQQHQLISQYQQQQQQ---------QQQQ 1194
            ....||.....|.|.:..|            .|:.....:::||.......|         |:|:
  Fly   991 KTYISRTESHNLSLDKSRS------------SASNMVDDYEIISPATHPPNQISSSPLHIKQEQE 1043

  Fly  1195 QQQQPQQQQQHHLAQQQQQHMRSHTPQSPHPPHPSQLQQ--QQPQQH-------FSSPHHMPP-- 1248
            |||:.|.....:|...... :|..|.:..:|...:.|::  :.|.:|       |:|.....|
  Fly  1044 QQQRVQLMYDDNLLIDAAL-LREKTYEKFNPSIVNDLEEILRSPLKHERNSRLRFTSESSTTPQY 1107

  Fly  1249 MHHQHQLMMQQQHRHNQRSPLHHHPAAQQLQQQHQQPSHS 1288
            :|.:.|.:::.:    ..||    ...:.|:.|.:..:||
  Fly  1108 LHEEEQNLIKIE----PTSP----DLREMLEGQQRVIAHS 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10543	NP_001369100.1	C2H2 Zn finger	727..747	CDD:275368	6/19 (32%)
		C2H2 Zn finger	751..773	CDD:275368	8/23 (35%)
		C2H2 Zn finger	781..801	CDD:275368	4/19 (21%)
		PHA00733	<804..860	CDD:177301	19/86 (22%)
		C2H2 Zn finger	811..827	CDD:275368	6/16 (38%)
		C2H2 Zn finger	839..860	CDD:275368	10/50 (20%)
		C2H2 Zn finger	868..888	CDD:275368	5/19 (26%)
		C2H2 Zn finger	897..913	CDD:275368	3/15 (20%)
		C2H2 Zn finger	926..946	CDD:275368	7/19 (37%)
		C2H2 Zn finger	954..975	CDD:275368	5/36 (14%)
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368	3/20 (15%)
		C2H2 Zn finger	170..186	CDD:275368	4/21 (19%)
		COG5048	326..734	CDD:227381	103/474 (22%)
		C2H2 Zn finger	343..363	CDD:275368	4/19 (21%)
		C2H2 Zn finger	371..391	CDD:275368	3/38 (8%)
		C2H2 Zn finger	424..444	CDD:275368	3/39 (8%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		C2H2 Zn finger	504..523	CDD:275368	7/21 (33%)
		C2H2 Zn finger	534..554	CDD:275370	4/19 (21%)
		C2H2 Zn finger	562..582	CDD:275370	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	9/19 (47%)
		C2H2 Zn finger	620..640	CDD:275368	1/19 (5%)
		C2H2 Zn finger	648..668	CDD:275368	5/19 (26%)
		zf-H2C2_2	661..685	CDD:290200	8/24 (33%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
		C2H2 Zn finger	709..726	CDD:275371	5/16 (31%)
		Hph	921..>1017	CDD:290417	16/107 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100