DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10543 and CG12299

DIOPT Version :9

Sequence 1:	NP_001369100.1	Gene:	CG10543 / 37379	FlyBaseID:	FBgn0034570	Length:	1666	Species:	Drosophila melanogaster
Sequence 2:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster

Alignment Length:	1055	Identity:	208/1055 - (19%)
Similarity:	341/1055 - (32%)	Gaps:	418/1055 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 QQQELVENQEEVQQEQEQQQQQLEDIQ----------------QQHLEEI--------QRQQQLP 386
            ||..|:..|.....:|:.||.|..|:.                .||:..:        |::|:.|
  Fly    21 QQTHLLPQQAPNPPQQQPQQPQPPDLTFHCMCCAEFFVHPLALYQHMNTLHPHEPGNGQQEQESP 85

  Fly   387 AISFGDSELESETESQLSSAAQEIMKFEEFIDEGVGAGRLIDGLEMEPEIDDMLAGAGSMNSASG 451
                ||   |||..|.:.....|:.:               ||                    |.
  Fly    86 ----GD---ESEDYSWIFEPVCELAE---------------DG--------------------SD 108

  Fly   452 HSSNSSSSGSGSAGNGNGISGVILENNSHHTHHLSSSSSANLVINGLTSSNSISNNNNNSNNVSL 516
            .|..|:||||.|:.:.:.      :::.......|||||::   |..:||:|:...:|::
  Fly   109 SSDGSASSGSDSSSSSDD------DDDDDDDDSSSSSSSSS---NSSSSSSSVPTTSNSN----- 159

  Fly   517 HRPQLTPQAQNQLAASMKPSDHIPISMPMENMDLKAGQAAHGTANAIMQGGSSSLASQLHQQQKP 581
                 |.|:|..:                        |..||.
  Fly   160 -----TQQSQESV------------------------QPLHGL---------------------- 173

  Fly   582 YNSSNNPLSMMGGMMQQQQQQHVAMPHHQRQMMMMPEDFPQHGASMMNSRQMPALAALSNLGDTP 646
                                  ||.|.:....:.|.:  |:...|:.  ...|.::.      ||
  Fly   174 ----------------------VAGPGYNEFQLQMTD--PRESTSIF--MVQPTVSV------TP 206

  Fly   647 AMSGQLNSSLELDDNDLSADEDDDDLDHDLDELDAAKQQLIDGGS--SSSTSLQAPPSQHGSGSG 709
            .                                    |||:....  |....||:.|.:...|..
  Fly   207 L------------------------------------QQLLPPAPTVSPGLGLQSTPIKRRRGRR 235

  Fly   710 GSGG---QTPGSKKDKPSYNCLLCPKSYRKRKSLLDHYKMH----PGYCHDCGQRNGNTLEEIIH 767
            .:.|   ..|....::..:.|..|..|:.....|..|.:.|    |..|..| |:....:..:..
  Fly   236 SNIGAPVMDPALNGNQKCFQCTHCEASFPNAGDLSKHVRSHITNKPFQCSIC-QKTFTHIGSLNT 299

  Fly   768 HNRTMHVKEFPFVCETCGESYSRKQQFHAHVESHNKKEIKTFPCGECG---LKFPQKKLQQ--HF 827
            |.| :|..|.|:.||.|.:::::......|:.||:.:  |...|.:|.   :.:....|.|  |.
  Fly   300 HIR-IHSGEKPYKCELCPKAFTQSSSLMVHMRSHSVR--KPHQCVQCDKGFINYSSLLLHQKTHI 361

  Fly   828 EETGHKADGAICEVCGEEFQSKNALYQHIIRVHKRDNFFECHICHNRFTLKANLERHVQLHTEIK 892
            ..|    :..||..|..||:::..|.:| :|:|.::..::|.||...|...:.|.:|::.|.. :
  Fly   362 APT----ETFICPECEREFKAEALLDEH-MRMHTQELVYQCAICREAFRASSELVQHMKNHMG-E 420

  Fly   893 RPYVCDLCGSSYFTYPALKEHYSNAHVDVSECKCTLCGKRFGSAKSLQRHLPSHSEERPHCCNYC 957
            :|:.|.||..|:....:|..| ...|......:|.||.|.|..|.||..|:..|:.|:|:.|..|
  Fly   421 KPFTCSLCDRSFTQSGSLNIH-MRIHTGEKPFQCKLCDKCFTQASSLSVHMKIHAGEKPYPCPIC 484

  Fly   958 DQTFKWKTHLVRHKQTMHGNEPPPPKKGKQRFPKTSEEDMGSLPDMPGPPPVKASKKAATSKAKA 1022
            .:::..:.:|.:|.|. |
  Fly   485 GKSYSQQAYLNKHIQA-H----------------------------------------------- 501

  Fly  1023 QAAAAAAAAASSQQQQQKGSAATPTPPPPVSTTPGCLQQDPFNAAMV-----SSNSSQSSTAS-- 1080
            |.|:||:|                      ||:||.|.....:..:|     |.::..::.||
  Fly   502 QMASAASA----------------------STSPGLLVAKQPHETLVCIVCGSLHADATALASHV 544

  Fly  1081 TSQHSVSTSESQQNSIYNQSFNAEKQQPGQQQPQNTLHQQHPTPPPPQQQQQQQQQQQALPQSRV 1145
            .|||:......:|:.:        ...||...|.        .....::||...::.|.:
  Fly   545 HSQHAALLDTMKQSGM--------NTAPGGAIPD--------VKCSAEEQQAYVERVQCV----- 588

  Fly  1146 GPGELHLQRMNSFGQDGQFHFESNPAAGAYQQHQLISQYQQQQQQQQQQQQQQPQQQQQHHLAQQ 1210
                  ||:||                     ||  .|:||.|||..|||||.||||||.||.||
  Fly   589 ------LQQMN---------------------HQ--QQHQQHQQQPPQQQQQHPQQQQQQHLQQQ 624

  Fly  1211 QQQHMRSHTPQSPHPPHPSQLQQQQPQQHFSSPHHMPPMHHQHQLMMQQQHRHNQRSPLHHHPAA 1275
                           ||..||.||            |.:                       ||.
  Fly   625 ---------------PHQMQLPQQ------------PKL-----------------------PAM 639

  Fly  1276 QQLQQQHQQPSHSPQHQHARLQSPQPAPVQQQQQQQQQQQQQQQQFLQQQAADTWGNMNFGNP-- 1338
            ....:..::|.          ::.:|...:::|.:.::..:.:.:.|..:.|.|    |.|.|
  Fly   640 DSTGEDEEEPD----------EAEEPPDEEEEQDEPEEPAEVKTEVLAAEDALT----NPGYPIL 690

  Fly  1339 -PNNQQVELKDNKFY 1352
             ...:|:.|..:.:|
  Fly   691 GLQEEQILLDSDMYY 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10543	NP_001369100.1	C2H2 Zn finger	727..747	CDD:275368	5/19 (26%)
		C2H2 Zn finger	751..773	CDD:275368	5/21 (24%)
		C2H2 Zn finger	781..801	CDD:275368	4/19 (21%)
		PHA00733	<804..860	CDD:177301	15/60 (25%)
		C2H2 Zn finger	811..827	CDD:275368	4/20 (20%)
		C2H2 Zn finger	839..860	CDD:275368	7/20 (35%)
		C2H2 Zn finger	868..888	CDD:275368	6/19 (32%)
		C2H2 Zn finger	897..913	CDD:275368	5/15 (33%)
		C2H2 Zn finger	926..946	CDD:275368	9/19 (47%)
		C2H2 Zn finger	954..975	CDD:275368	5/20 (25%)
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	42/167 (25%)
		C2H2 Zn finger	256..276	CDD:275368	5/19 (26%)
		zf-H2C2_2	268..293	CDD:290200	7/25 (28%)
		C2H2 Zn finger	284..304	CDD:275368	5/21 (24%)
		zf-H2C2_2	296..321	CDD:290200	8/25 (32%)
		zf-C2H2_2	312..>387	CDD:289522	20/81 (25%)
		C2H2 Zn finger	312..332	CDD:275368	4/19 (21%)
		C2H2 Zn finger	340..360	CDD:275368	4/19 (21%)
		C2H2 Zn finger	369..389	CDD:275368	7/20 (35%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		zf-H2C2_2	409..434	CDD:290200	8/25 (32%)
		C2H2 Zn finger	425..445	CDD:275368	6/20 (30%)
		zf-H2C2_2	437..462	CDD:290200	8/25 (32%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		zf-H2C2_2	465..490	CDD:290200	8/24 (33%)
		C2H2 Zn finger	481..501	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100