DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10543 and spr-4

DIOPT Version :9

Sequence 1:	NP_001369100.1	Gene:	CG10543 / 37379	FlyBaseID:	FBgn0034570	Length:	1666	Species:	Drosophila melanogaster
Sequence 2:	NP_001020993.1	Gene:	spr-4 / 172596	WormBaseID:	WBGene00005009	Length:	1311	Species:	Caenorhabditis elegans

Alignment Length:	1281	Identity:	211/1281 - (16%)
Similarity:	370/1281 - (28%)	Gaps:	495/1281 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   475 LENNSHHTHHL------SSSSSAN---------------LVINGLTSSNSISNNNNNSNNVSLHR 518
            :||:..|..|.      |.||.||               |.....::..|::::||      :|
Worm   106 IENSGPHACHKCPSRYESKSSLANHTKMHLGEKRKFACELCDFSASTLKSLTHHNN------IH- 163

  Fly   519 PQLTPQAQNQLAASMKPSDHIPISMPMENMDLKAGQAAHGTANAIMQGGSSSLASQLHQQQKPYN 583
                   ||....|.:.|..||::               .:|::.:....:|...|::....|..
Worm   164 -------QNFGVLSQQTSPVIPVA---------------SSADSTLNSSINSTGCQINAPPAPKL 206

  Fly   584 SSNNPLSMMGGMMQQQ-------------QQQHVAMPHHQRQMMMMPEDFP----QHGASMMNSR 631
            ....|:::...::..:             :::....|...|:..:...:.|    |....|...|
Worm   207 DEEAPIAVESVVVHHEDVAEFDTTPPPILEREDDGPPVLIREAPVRKSNRPMKPTQKAQKMTKQR 271

  Fly   632 QMPALAALSNLGDTPAMSGQLNSSL-------ELDDNDLSADEDDDDLDHDLDELDAAKQQLIDG 689
            :..:....|..|..|:.|.   ||:       :::...:.......:|...: ::...:|:....
Worm   272 ERKSKTVESPKGSLPSSSA---SSVTPPPVRKDVEKPKIFVKTTKKNLKKTM-KITKVRQRCPHC 332

  Fly   690 GSSSSTSLQAPPSQHGSGSGGSGGQTPGSKKDKPSYNC-LLCPKSYRKRKSLLDHYKMH------ 747
            ..::||..:.  ::|      |||.........||.|| .:|    ||...|..||.:|
Worm   333 PFTTSTVTRL--NRH------SGGHKLKEGYICPSENCNFMC----RKAGFLQKHYILHKGTLPW 385

  Fly   748 -PGYCHDCG----------------------------QRNGNTLEE------------------- 764
             |.|....|                            :|..||::.
Worm   386 PPEYVKKGGAKMKRTFPESEEKKIEVTEKVQKMKKMHKRRANTVQVVAKAQLKSYIKVEVDDVIF 450

  Fly   765 ------------------IIHHNRTMHVK-EFP---FVCETCG---ESYS--RKQQFHAHVESHN 802
                              |:|..:|...| .||   |:|.|||   :||:  |..:...|..:|
Worm   451 KKCNIGECEFLTQTLTQLIVHKVKTHDTKTAFPQHRFLCLTCGHRAKSYAALRTHKLIEHTSTH- 514

  Fly   803 KKEIKTFPCGEC-GLKFPQK----KLQQHFEETGHKADG-----------------------AI- 838
            |:..:|:...|| |.||..|    |:|:..:|...:|||                       ||
Worm   515 KRFHRTYYLKECVGDKFFVKYNLSKVQEEVKEEPKEADGDESGDESFDSMCPASDVHPETLAAIE 579

  Fly   839 -------CEVCGEEFQSKNALYQHIIRVHKRDNFFECHIC------------HNRF--------- 875
                   |.:|..:..:.|...:|..:..|.|. |:|..|            |.:.
Worm   580 MKDVFFCCNMCPYKAPTMNRCQRHYDKHFKNDE-FKCQYCSWSSRSKEVIVNHEKLHPTVVVANT 643

  Fly   876 ----TLKANLERHVQ-LHTEIKRPYVCD-----------LCGSSYFTYPALKEHYSNAHVD---- 920
                .:|..:|..|: |...:..|..|.           .|......:|.|.|.::...:|
Worm   644 NEAPVVKNEIEAKVEVLSKTVSSPVECTEESSLSKSIQLWCQREKLRHPELDEQFTRKMIDGVKG 708

  Fly   921 --VSEC-----------------------KCTLCGKRFGSAKSLQRHLPSHS------------- 947
              .::|                       :|..|........||:.||..|:
Worm   709 FQCTDCPYTSKYRGDMRSHKKRHDIEQLYRCVQCTYTTNRPVSLKDHLKQHAIVNMSIADIKSRR 773

  Fly   948 ----------------EERPHCCNYCDQT-----FKWKTHLVRHKQT------------------ 973
                            :::.:||:.|...     ..|:.|. .|:.|
Worm   774 VVVNQGVKIGMRRGVGKDKIYCCDKCPYVTLALGCLWRHHR-NHRDTAKINICSNCSYSSIDQRK 837

  Fly   974 ----------MHGNEPPP-----PKKGKQRFPKTSEEDMGSLPDMPGPPPVKASKKAATSKA--- 1020
                      :..||..|     .:||:   |.:|..|:.|         .|.:::.:|.:.
Worm   838 MEEHTIIHLGLGLNEAVPFVKRVDQKGR---PVSSLTDLNS---------EKMNERKSTKRKMLD 890

  Fly  1021 KAQAAAAAAAAASSQQQQQKGSAATPTPPPPVSTTPGCLQQDPFNAAMVSSNSSQSST---ASTS 1082
            |.:...........::...||            |..|..:|.|......||....|..   .|:|
Worm   891 KVEKMEVGEDEEDDEESVDKG------------TDDGDYKQRPEKKRKQSSEEPASDPELFGSSS 943

  Fly  1083 QHSVSTSESQQNSIYNQSFNAEKQQPGQQQPQNTLHQQHPTPPPPQQQQQQQQQQQALPQSRVGP 1147
            |.:...||....:..|.|. ..|...|:           |||                     ..
Worm   944 QPTRQLSERATRNRINYSL-LSKNGSGK-----------PTP---------------------ST 975

  Fly  1148 GELHLQRMNSFGQDGQFHFES-NPAAGAYQQHQLISQYQQQQQQQQQQ--------QQQQPQQQQ 1203
            ...:|:::  .|..|....|| .|.......|..|..:.:.:...::.        :..:|...:
Worm   976 SSANLEKL--AGSSGGASSESPEPDESVEVSHWKIRTFLRSEYGVKESLKCPDCPYKSSEPDVLE 1038

  Fly  1204 QHHLAQQQQQHMRSHTPQSPHPPHPSQLQQQQPQ---QHF---SSPHHMPPMHHQHQLMMQQQHR 1262
            :|     :..||...||: |:...........|.   ||.   |...:..||..:|     .:||
Worm  1039 KH-----RYYHMTKTTPR-PYACSDCTFNTYTPTALLQHLKLHSEGVYFDPMVKKH-----MKHR 1092

  Fly  1263 HNQRSPLHHHPAAQ---------QLQQQHQQPSHSPQHQHARLQ------SPQPAPVQQQQQQQQ 1312
            .....|    |..:         :.........||..|:...:.      ..||..::.|:.:.:
Worm  1093 KGDSIP----PGVKGYYCKNCSFKTSIHRNFIEHSAYHRQQLINRINITLKRQPPRIEYQRPKLK 1153

  Fly  1313 QQ---------------QQQQQQFLQQQAADTWGNM----------NFGNPPNNQQVE---LKDN 1349
            .|               ...|..|::......|..:          |..:..:..|:.   :||.
Worm  1154 HQFVAKNAKYCKKCTFKCVSQSNFIEHLDRHGWNQLYKCYSCDYSDNTKSVVDFHQLNHHIVKDQ 1218

  Fly  1350 KFY-IVESAEFLGLPMNVPPSPQQQQQQAVSKPQQQQQQQHPQPQQ 1394
            ..: |.:||:|            :.:...:..|:.|.::..|.|.:
Worm  1219 TLHSICQSAKF------------RLENGVIQIPEFQTEKSKPTPDE 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10543	NP_001369100.1	C2H2 Zn finger	727..747	CDD:275368	7/20 (35%)
		C2H2 Zn finger	751..773	CDD:275368	7/86 (8%)
		C2H2 Zn finger	781..801	CDD:275368	8/24 (33%)
		PHA00733	<804..860	CDD:177301	19/91 (21%)
		C2H2 Zn finger	811..827	CDD:275368	8/20 (40%)
		C2H2 Zn finger	839..860	CDD:275368	4/20 (20%)
		C2H2 Zn finger	868..888	CDD:275368	6/45 (13%)
		C2H2 Zn finger	897..913	CDD:275368	4/26 (15%)
		C2H2 Zn finger	926..946	CDD:275368	6/19 (32%)
		C2H2 Zn finger	954..975	CDD:275368	6/53 (11%)
spr-4	NP_001020993.1	C2H2 Zn finger	114..134	CDD:275368	6/19 (32%)
spr-4	NP_001020993.1	C2H2 Zn finger	143..163	CDD:275368	4/25 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930