DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha3 and PRE9

DIOPT Version :9

Sequence 1:	NP_476691.1	Gene:	Prosalpha3 / 37378	FlyBaseID:	FBgn0261394	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_011651.3	Gene:	PRE9 / 853036	SGDID:	S000003367	Length:	258	Species:	Saccharomyces cerevisiae

Alignment Length:	260	Identity:	132/260 - (50%)
Similarity:	183/260 - (70%)	Gaps:	8/260 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ARRYDSRTTIFSPEGRLYQVEYAMEAISHAGTCLGILAEDGILLAAECRSTNKLLDSAIPSEKIY 66
            :||||||||||||||||||||||:|:||||||.:||:|.|||:||||.:.|:.||:....:||:|
Yeast     3 SRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMASDGIVLAAERKVTSTLLEQDTSTEKLY 67

  Fly    67 RLNDNMVCSVAGITSDANVLTSELRLIAQRYQFSYGEVIPCEQLVSHLCDIKQAYTQYGGKRPFG 131
            :|||.:..:|||:|:||.:|.:..|:.||.|..:|.|.||.|.||..|.||||.|||:||.||||
Yeast    68 KLNDKIAVAVAGLTADAEILINTARIHAQNYLKTYNEDIPVEILVRRLSDIKQGYTQHGGLRPFG 132

  Fly   132 VSLLYMGWDNKYGYQLYQSDPSGNYGGWKATCIGNNFGAAISMLKQELADKENVKLTLADAKDLA 196
            ||.:|.|:|::||||||.|:|||||.||||..:|.|..||.::|:.:..|...|.    ||.:||
Yeast   133 VSFIYAGYDDRYGYQLYTSNPSGNYTGWKAISVGANTSAAQTLLQMDYKDDMKVD----DAIELA 193

  Fly   197 IKVLSMTLDTTKLTPEKVEMATLQR-VDNKTVYSVLEKP-DVEKLIEK--YTKVQAEAEAAKKEK 257
            :|.||.|.|::.||.:::|.||::: .::..||..:.|| :::.::.|  .||...:.||.:..|
Yeast   194 LKTLSKTTDSSALTYDRLEFATIRKGANDGEVYQKIFKPQEIKDILVKTGITKKDEDEEADEDMK 258

Fly 258 257
Yeast 259 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha3	NP_476691.1	PTZ00246	1..245	CDD:173491	127/246 (52%)
Prosalpha3	NP_476691.1	proteasome_alpha_type_4	3..219	CDD:239721	121/215 (56%)
PRE9	NP_011651.3	proteasome_alpha_type_4	4..216	CDD:239721	121/215 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345964
Domainoid	1	1.000	193	1.000	Domainoid score	I617
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2083
Inparanoid	1	1.050	248	1.000	Inparanoid score	I665
Isobase	1	0.950	-	0	Normalized mean entropy	S260
OMA	1	1.010	-	-		QHG54118
OrthoFinder	1	1.000	-	-		FOG0003645
OrthoInspector	1	1.000	-	-		otm46517
orthoMCL	1	0.900	-	-		OOG6_101968
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1006
SonicParanoid	1	1.000	-	-		X2516
TreeFam	1	0.960	-	-
	16	15.740