DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha3 and PSMA4

DIOPT Version :9

Sequence 1:	NP_476691.1	Gene:	Prosalpha3 / 37378	FlyBaseID:	FBgn0261394	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_001096137.1	Gene:	PSMA4 / 5685	HGNCID:	9533	Length:	261	Species:	Homo sapiens

Alignment Length:	264	Identity:	186/264 - (70%)
Similarity:	219/264 - (82%)	Gaps:	3/264 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARRYDSRTTIFSPEGRLYQVEYAMEAISHAGTCLGILAEDGILLAAECRSTNKLLDSAIPSEKI 65
            |:||||||||||||||||||||||||||.||||||||||.||:|||||.|:.:||||....||||
Human     1 MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKI 65

  Fly    66 YRLNDNMVCSVAGITSDANVLTSELRLIAQRYQFSYGEVIPCEQLVSHLCDIKQAYTQYGGKRPF 130
            |:||::|.||||||||||||||:|||||||||...|.|.|||||||:.||||||||||:||||||
Human    66 YKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPF 130

  Fly   131 GVSLLYMGWDNKYGYQLYQSDPSGNYGGWKATCIGNNFGAAISMLKQELADKENVKLTLADAKDL 195
            ||||||:|||..||:||||||||||||||||||||||..||:|||||:..:.|   :||..|..|
Human   131 GVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGE---MTLKSALAL 192

  Fly   196 AIKVLSMTLDTTKLTPEKVEMATLQRVDNKTVYSVLEKPDVEKLIEKYTKVQAEAEAAKKEKQAK 260
            |||||:.|:|.:||:.||||:|||.|.:.|||..||::.:||:||:|:.:.:|:||..||||:.|
Human   193 AIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQK 257

  Fly   261 QPTK 264
            :..|
Human   258 EKDK 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha3	NP_476691.1	PTZ00246	1..245	CDD:173491	177/243 (73%)
Prosalpha3	NP_476691.1	proteasome_alpha_type_4	3..219	CDD:239721	163/215 (76%)
PSMA4	NP_001096137.1	proteasome_alpha_type_4	3..216	CDD:239721	163/215 (76%)
PSMA4	NP_001096137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..261		8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158454
Domainoid	1	1.000	277	1.000	Domainoid score	I1741
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2083
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2146
Isobase	1	0.950	-	0	Normalized mean entropy	S260
OMA	1	1.010	-	-		QHG54118
OrthoDB	1	1.010	-	-		D1222564at2759
OrthoFinder	1	1.000	-	-		FOG0003645
OrthoInspector	1	1.000	-	-		oto89706
orthoMCL	1	0.900	-	-		OOG6_101968
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1006
SonicParanoid	1	1.000	-	-		X2516
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	18	17.750