DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha3 and pas-3

DIOPT Version :9

Sequence 1:	NP_476691.1	Gene:	Prosalpha3 / 37378	FlyBaseID:	FBgn0261394	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_001379751.1	Gene:	pas-3 / 172139	WormBaseID:	WBGene00003924	Length:	250	Species:	Caenorhabditis elegans

Alignment Length:	256	Identity:	164/256 - (64%)
Similarity:	198/256 - (77%)	Gaps:	6/256 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARRYDSRTTIFSPEGRLYQVEYAMEAISHAGTCLGILAEDGILLAAECRSTNKLLDSAIPSEKI 65
            ||||||||||||||||||||||||||||||||||||||:.:||::|||.::.:||||.::.:||:
Worm     1 MARRYDSRTTIFSPEGRLYQVEYAMEAISHAGTCLGILSSEGIVVAAERKNVHKLLDDSVMTEKV 65

  Fly    66 YRLNDNMVCSVAGITSDANVLTSELRLIAQRYQFSYGEVIPCEQLVSHLCDIKQAYTQYGGKRPF 130
            |||:||:.|:|||||:|||:|.:.||..|..|:.||||.:|.||||.:||:.||.|||.||||||
Worm    66 YRLSDNISCTVAGITADANILINHLRWWAASYRNSYGEEMPVEQLVQNLCNEKQRYTQIGGKRPF 130

  Fly   131 GVSLLYMGWDNKYGYQLYQSDPSGNYGGWKATCIGNNFGAAISMLKQELADKENVKLTLADAKDL 195
            ||||||:|||..||||||||||||||.||||||||:|..||:::||||....     .|.:||.|
Worm   131 GVSLLYIGWDKHYGYQLYQSDPSGNYTGWKATCIGSNHQAAVTLLKQEYKSP-----NLEEAKQL 190

  Fly   196 AIKVLSMTLDTTKLTPEKVEMATLQRVDNKTVYSVLEKPDVEKLIEKYTKVQAEAEAAKKE 256
            |||||..||| .||..||||||.|.|.|.|||...|...:|:.||.::.|.:.|||.|:|:
Worm   191 AIKVLWKTLD-VKLASEKVEMAVLTRRDGKTVLEELTTKEVDALIAEHEKKEKEAETAEKK 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha3	NP_476691.1	PTZ00246	1..245	CDD:173491	158/243 (65%)
Prosalpha3	NP_476691.1	proteasome_alpha_type_4	3..219	CDD:239721	146/215 (68%)
pas-3	NP_001379751.1	proteasome_alpha_type_4	3..213	CDD:239721	146/215 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166112
Domainoid	1	1.000	237	1.000	Domainoid score	I1297
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2083
Inparanoid	1	1.050	318	1.000	Inparanoid score	I1509
Isobase	1	0.950	-	0	Normalized mean entropy	S260
OMA	1	1.010	-	-		QHG54118
OrthoDB	1	1.010	-	-		D1222564at2759
OrthoFinder	1	1.000	-	-		FOG0003645
OrthoInspector	1	1.000	-	-		otm14587
orthoMCL	1	0.900	-	-		OOG6_101968
Panther	1	1.100	-	-	LDO	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1006
SonicParanoid	1	1.000	-	-		X2516
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790