DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3216 and CYR1

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	991	Identity:	182/991 - (18%)
Similarity:	320/991 - (32%)	Gaps:	339/991 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 SEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTRMS-YCQCRLILVFASVIR------QFNW 253
            |..:||..||  ..:.||.:..|.|............:| ..|..:..|.|:.::      .::|
Yeast  1218 SGNKLTTLSG--DTVLKWSSLKTLMLNSNQMLSLPAELSNLSQLSVFDVGANQLKYNISNYHYDW 1280

  Fly   254 NHVALLVDRSELFSWTVGKNLEY----GLRQEGLLSFVK-ELNGNEEEVYENYLKDASMYARVVI 313
            |             |...|.|:|    |.|:..:.||:. :::.:        |.|.::..::.:
Yeast  1281 N-------------WRNNKELKYLNFSGNRRFEIKSFISHDIDAD--------LSDLTVLPQLKV 1324

  Fly   314 LSVRGVLVR---------KFMLAAHSLGMTNGEWVFLDVEIFQSEYWGDKGWEMKDEHDAKARKA 369
            |.:..|.:.         .|.|.. :..:.||....:...:.|.:|
Yeast  1325 LGLMDVTLNTTKVPDENVNFRLRT-TASIINGMRYGVADTLGQRDY------------------- 1369

  Fly   370 YEALLRVSLLQPTSPKFQD--------FADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLG 426
                  ||....|..:|:.        ..|:..:||.|.:|        ::..:...||.:
Yeast  1370 ------VSSRDVTFERFRGNDDECLLCLHDSKNQNADYGHN--------ISRIVRDIYDKI---- 1416

  Fly   427 MALNETLTEGGD-----IRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFS 486
              |...|...||     |:..:..:....|:...|:...|   |||...|:.|..||  ::|..|
Yeast  1417 --LIRQLERYGDETDDNIKTALRFSFLQLNKEINGMLNSV---DNGADVANLSYADL--LSGACS 1474

  Fly   487 VVAHYSGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCV-------GNFSTIMYSVFG 544
            .|.:          :.|||:                 |..|..||:       |::.|
Yeast  1475 TVIY----------IRGKKL-----------------FAANLGDCMAILSKNNGDYQT------- 1505

  Fly   545 LLLFLGLVFLVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFGSKGGLQRLD-VENISLQQF 608
                          |.||...:|         |.:...|.:.|.:.:.|   :|| |.::|
Yeast  1506 --------------LTKQHLPTK---------REEYERIRISGGYVNNG---KLDGVVDVS---- 1540

  Fly   609 GIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVD----LTPQLLWE---IKQARDVS 666
                 ||  ..|..|.|.::.:        ..|..|.:.|.|    :....|||   :....|::
Yeast  1541 -----RA--VGFFDLLPHIHAS--------PDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIA 1590

  Fly   667 HENTVRFVGACIDL----------PRPTVLILTEY-----------------CSRGSLKDV---- 700
            .||:...:.|..:|          ...|:|.|..|                 ..|.:.:|.
Yeast  1591 RENSTDPLRAAAELKDHAMAYGCTENITILCLALYENIQQQNRFTLNKNSLMTRRSTFEDTTLRR 1655

  Fly   701 LENEAIELDWNFRMSLIHDIVKGMNYL-------HNSDVAAHGKLRSCNCLIDGRFVLKI-SDFG 757
            |:.|......|  ::::...:|...:|       ..:.:..|..:......|.|.:.:|. .|..
Yeast  1656 LQPEISPPTGN--LAMVFTDIKSSTFLWELFPNAMRTAIKTHNDIMRRQLRIYGGYEVKTEGDAF 1718

  Fly   758 LRTLTTP-SDFVRDQNYYLKLL---WIAPELLPLTTIPGCCPATQR-GDVYSFGIILEEIVNRGG 817
            :....|| |......:..||||   |  ||  .:|::...|..|.| |::...|:.:...::.|.
Yeast  1719 MVAFPTPTSGLTWCLSVQLKLLDAQW--PE--EITSVQDGCQVTDRNGNIIYQGLSVRMGIHWGC 1779

  Fly   818 PYQE---ARQQMDVHTILHKVRQCNGFRPLIRERECPPDLLELMEKCWADNQEERPTFSTIRSNI 879
            |..|   ..|:||.            ..|::.:                            .:.:
Yeast  1780 PVPELDLVTQRMDY------------LGPMVNK----------------------------AARV 1804

  Fly   880 RTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQILPRPVAQQLMAG-- 942
            :.:..|....:..|..:...:.....|.:|:.|.   ||::...||::.::|.|.:|.....|
Yeast  1805 QGVADGGQIAMSSDFYSEFNKIMKYHERVVKGKE---SLKEVYGEEIIGEVLEREIAMLESIGWA 1866

  Fly   943 --DL-------VEPEEFSSVTIYFSDIVGFT-ELCARSSPMDVVN---------FLNDLYSTFDR 988
              |.       :|.:|.  |||.:..|:... |..:......::|         ..|.|.|....
Yeast  1867 FFDFGEHKLKGLETKEL--VTIAYPKILASRHEFASEDEQSKLINETMLFRLRVISNRLESIMSA 1929

  Fly   989 IIGFYDVYKVETIGDAYL-----VVSGLPEPNGDKHAREIALMALD--ILRAVSSFNLRHKPEYK 1046
            :.|.:......|.| :|:     |.:|:.:...:|.    ||:..|  |.|..||..|.|..:.:
Yeast  1930 LSGGFIELDSRTEG-SYIKFNPKVENGIMQSISEKD----ALLFFDHVITRIESSVALLHLRQQR 1989

  Fly  1047 IQIRIGMHSGSVCAGV 1062
                        |:|:
Yeast  1990 ------------CSGL 1993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	62/333 (19%)
		ANF_receptor	107..479	CDD:279440	58/316 (18%)
		PKc_like	616..885	CDD:304357	54/322 (17%)
		TyrKc	627..877	CDD:197581	51/303 (17%)
		HNOBA	<882..939	CDD:285003	12/56 (21%)
		CYCc	918..1109	CDD:214485	37/173 (21%)
		Guanylate_cyc	945..1131	CDD:278633	29/135 (21%)
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473
		PLN00113	792..>1273	CDD:215061	13/56 (23%)
		leucine-rich repeat	796..817	CDD:275380
		leucine-rich repeat	818..839	CDD:275380
		leucine-rich repeat	840..864	CDD:275380
		leucine-rich repeat	865..887	CDD:275380
		leucine-rich repeat	888..910	CDD:275380
		leucine-rich repeat	911..933	CDD:275380
		leucine-rich repeat	934..956	CDD:275380
		leucine-rich repeat	957..978	CDD:275380
		leucine-rich repeat	979..1018	CDD:275380
		leucine-rich repeat	1019..1041	CDD:275380
		leucine-rich repeat	1042..1065	CDD:275380
		leucine-rich repeat	1066..1088	CDD:275380
		leucine-rich repeat	1089..1111	CDD:275380
		leucine-rich repeat	1167..1187	CDD:275380
		leucine-rich repeat	1191..1211	CDD:275380
		leucine-rich repeat	1236..1258	CDD:275380	3/21 (14%)
		leucine-rich repeat	1259..1287	CDD:275380	5/40 (13%)
		PP2C	1374..1617	CDD:395385	65/340 (19%)
		CYCc	1613..1825	CDD:214485	41/257 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900