DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and GLR1.3

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_199652.1	Gene:	GLR1.3 / 834896	AraportID:	AT5G48410	Length:	860	Species:	Arabidopsis thaliana

Alignment Length:	763	Identity:	150/763 - (19%)
Similarity:	254/763 - (33%)	Gaps:	224/763 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 SKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSWTVGKNL------EYGLRQEGL 283
            |||..|.:.::..........|.|..|:||.|||:.:..:  .|.....|      |.|:|.:..
plant   145 SKYTHLIQATHDSTSEAKGITSFINVFDWNSVALVYEDHD--DWRESMQLLVEHFHENGVRVQSK 207

  Fly   284 LSFVKELNGNEEEVYE--NYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEWVF-LDVEI 345
            :.|.  ::.:|:.|..  ..|||......||.||  .|:.......|..||:....:|: |..:.
plant   208 VGFT--VSSSEDFVMGRLQQLKDLGTTVFVVHLS--EVIATHLFPCARRLGLMGDGFVWILTAKT 268

  Fly   346 FQSEYWGDKGWEMKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEE 410
            ..|         ..:..|...::|.|.::......|.|.:.|:|....|::...:      |.|.
plant   269 MNS---------FHENIDDFTKQAMEGVVGFKSYIPMSIELQNFTLRWRKSLPVE------EAEL 318

  Fly   411 VNFFIGAF--YDGVYLLGMA--------LNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDD 465
            ....|...  :|..:.|..|        :..||.|        .||:..:|    |::|..:::|
plant   319 TRLSISGIWAHDIAFALARAAEVIRMPNVTSTLLE--------EITKTRFN----GLSGDFQLND 371

  Fly   466 NGDRDADYSILDLD----------PINGKFSVVAHYSGVHKVYSAVHGKKIHWPGGREEPP---- 516
            .......:.|:::.          ..||.||...|.|..|...     :.|.||||..:.|
plant   372 KKLLSNKFEIINMIGSSERRVGFLNSNGSFSNRRHLSSTHNKL-----ETIIWPGGSAQSPKGTS 431

  Fly   517 ---PDVPPCGFLGNSTDCVGNFSTIMY----SVFGLLLFLGLVFLV----ICLLQKQMKLSKELN 570
               .|......|..|::   .|..:|.    .|...|:..|....|    |.....:::....||
plant   432 LIDSDRKKLRVLVTSSN---RFPRLMKVETDPVTNELIVEGFCIEVFRASISPFNYEVEYIPWLN 493

  Fly   571 NMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFK 635
            ..::    |::...:.         .:.|..:.::....|.|.|::...|| ||   :|.:|.
plant   494 GSNY----DNLAYALH---------SQKDKYDAAVGDITITSNRSTYVDFT-LP---FTEMGL-- 539

  Fly   636 GERVAIKKVN--VKKVDLTPQL--------------LWEIKQARDVSHENT-VRFVGACIDLPRP 683
             ..||:|:.:  |....|||.|              :|.|::|.:...:.: .:.:|..:.....
plant   540 -GIVAVKERSMWVFFQPLTPDLWITSAFFFVLTGVIVWLIERAENKEFQGSWPQQIGVVLWFGFS 603

  Fly   684 TVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHD----------IVKGMNYLHNSDVAAHGKL 738
            |::    |..|..||..|....:.: |.|.:.::..          .|:.:.:..|.|...|
plant   604 TLV----YAHREKLKHNLSRFVVTV-WVFAVLILTASYTATLTSMMTVQQIRFNSNEDYVGH--- 660

  Fly   739 RSCNCLIDGRFVLKI------------------SDFGLRTLTTPSDFVRDQNYYLKLLWIAPELL 785
                  :.|..:..:                  :|:....|.....||.|:..|||
plant   661 ------LSGSLIANVALTSSSLRAMRSLGLNSAADYAQALLNKTVSFVVDELPYLK--------- 710

  Fly   786 PLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQ-CNGFRPLIRER- 848
                                 ::|.|     .|         .|..:.|.:. .|||..:.::.
plant   711 ---------------------VVLGE-----NP---------THFFMVKTQSTTNGFGFMFQKGF 740

  Fly   849 ECPPDL------------LELMEKCWADNQEERPTFSTIRSNIRTIMK 884
            |..|::            |..|||.|.|||....|..|  ||..|:.:
plant   741 ELVPNVSREISKLRTSEKLNEMEKRWFDNQLPYTTDDT--SNPITLYR 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	64/299 (21%)
		ANF_receptor	107..479	CDD:279440	58/272 (21%)
		PKc_like	616..885	CDD:304357	62/328 (19%)
		TyrKc	627..877	CDD:197581	55/308 (18%)
		HNOBA	<882..939	CDD:285003	0/3 (0%)
		CYCc	918..1109	CDD:214485
		Guanylate_cyc	945..1131	CDD:278633
GLR1.3	NP_199652.1	PBP1_GABAb_receptor	43..405	CDD:107361	62/292 (21%)
		ANF_receptor	57..385	CDD:279440	58/272 (21%)
		GluR_Plant	438..767	CDD:270404	69/409 (17%)
		Lig_chan	559..798	CDD:278489	49/288 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910