DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and si:dkey-37g12.1

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	XP_021333677.1	Gene:	si:dkey-37g12.1 / 796669	ZFINID:	ZDB-GENE-090312-145	Length:	882	Species:	Danio rerio

Alignment Length:	848	Identity:	381/848 - (44%)
Similarity:	529/848 - (62%)	Gaps:	47/848 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 YENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIF-QSEYWGDKGWEMKDE 361
            :...|.:.:..||::::|..|.:||..::.||..|:|||::||...|.: |...:|...||..|.
Zfish    61 WSRVLNEMAQVARIIVISAHGKVVRSLLIEAHKKGLTNGDFVFFCFEPYKQKVLFGSFDWEQGDS 125

  Fly   362 HDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLG 426
            :|:.|::||:||..:||.:|:..::|.|::||...:..|:.||:.:.|:|:......:|.|:|..
Zfish   126 YDSMAKQAYQALFFLSLYKPSDKRYQAFSENVISRSKIDFGYTYAQTEKVSVLAAIAHDTVWLYA 190

  Fly   427 MALNETLTEGGDIRDGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHY 491
            .||||||.|.|:..||:.:||||||||.:||.|.|.||.:|||:.:|.:..:...|.:..|||:|
Zfish   191 HALNETLAENGNPYDGLAVTRRMWNRTIKGIQGDVTIDASGDRELNYMMKQIRGSNNQCQVVANY 255

  Fly   492 SGVHKVYSAVHGKKIHWPGGREEPPPDVPPCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLV---F 553
            .|   .|.||.|.:|.||||...||.|.|.|||.|..  |: |.........|::  .||:   .
Zfish   256 FG---TYKAVKGVQILWPGGLTSPPKDSPDCGFRGEL--CI-NLERKFLIALGII--AGLMAAGT 312

  Fly   554 LVICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRASIA 618
            |.||:|.::.||.:|.:.|.|.:..:||::              ::..:.::.:.. |..:...|
Zfish   313 LAICVLYRKYKLPEEASKMLWTINANDVIM--------------MEHHSSTVPEKS-HRSKPLQA 362

  Fly   619 SFTSL------PPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGAC 677
            |..|:      .|..:.| ..:||...::..||::...|..:||.|:||.||::|.|..:|:||.
Zfish   363 SLESIICSMQDKPSAHRT-AVYKGTICSVSFVNLRSTHLNSELLAELKQFRDLTHYNLCKFIGAA 426

  Fly   678 IDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCN 742
            ::..:|  .||||||.:|||:|:|:||:|:|||.|:.||:.||||||:|||:|.:..||.|.|.:
Zfish   427 LETSQP--FILTEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGMDYLHHSPLQYHGHLSSSS 489

  Fly   743 CLIDGRFVLKISDFGL---RTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDVYS 804
            |::|.|||||::||||   |.|.|......|.  :..|||.||||| ..:||  ...||:|||||
Zfish   490 CVVDSRFVLKVTDFGLNSVRRLDTEQSPGSDP--WTALLWRAPELL-RQSIP--ANGTQKGDVYS 549

  Fly   805 FGIILEEIVNRGGPYQEARQQMDVHTILHKVRQ--CNGFRPLIRERECPPDLLELMEKCWADNQE 867
            |.||.:|:|.|.||:...........|:.:||.  |:..||.|...||..:|..|:..||.:...
Zfish   550 FAIIAQEVVYRRGPFYIPNSHFSPREIVERVRAGGCSPSRPYIDRAECVEELESLVVSCWRETPA 614

  Fly   868 ERPTFSTIRSNI-RTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEELLYQIL 931
            |||.||.||:.| :....|..||::||||:||||||.|||.:|.|:|.:|..||:|.|.||.|:|
Zfish   615 ERPDFSYIRTAIKKNSPHGVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQML 679

  Fly   932 PRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIGFYDVY 996
            ||.||.||:||..|..|.:..||||||||.|||.:.|..:||.|||.|||||:.||.||.:::||
Zfish   680 PRSVASQLIAGKTVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVY 744

  Fly   997 KVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSGSVCAG 1061
            |||||||||:||||||..|||.||:|||.|:|.|::.:.||:..|.||.::::|||:|||...||
Zfish   745 KVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAG 809

  Fly  1062 VVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGTFQMEQRGDVELKGKGTVTT 1126
            |||.|||.||||||||||||||||.|.|.||||||:||::||.|..|:.|.|||:.:||||.|.|
Zfish   810 VVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIKGKGWVRT 874

  Fly  1127 YWL 1129
            :||
Zfish   875 FWL 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	76/198 (38%)
		ANF_receptor	107..479	CDD:279440	70/181 (39%)
		PKc_like	616..885	CDD:304357	118/280 (42%)
		TyrKc	627..877	CDD:197581	112/254 (44%)
		HNOBA	<882..939	CDD:285003	32/56 (57%)
		CYCc	918..1109	CDD:214485	120/190 (63%)
		Guanylate_cyc	945..1131	CDD:278633	117/185 (63%)
si:dkey-37g12.1	XP_021333677.1	Periplasmic_Binding_Protein_Type_1	<59..258	CDD:324556	76/199 (38%)
		PKc_like	355..628	CDD:328722	119/280 (43%)
		HNOBA	<641..687	CDD:311573	28/45 (62%)
		CYCc	666..850	CDD:214485	117/183 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3113
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820