DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3216 and Gucy2d

DIOPT Version :9

Sequence 1:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_077356.1	Gene:	Gucy2d / 79222	RGDID:	620438	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	1145	Identity:	392/1145 - (34%)
Similarity:	556/1145 - (48%)	Gaps:	191/1145 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 VYNVGVLMASHLDSPFDLERCGPAVDLALDEINKVFLKP----HNITLLKKKGSYPSCSGARAPG 148
            |:.||||.....|..|...|...|..||.|.:|:.....    ..:|||.:....|...||.:..
  Rat    56 VFKVGVLGPWACDPIFARARPDLAARLATDRLNRDLALDGGPWFEVTLLPEPCLTPGSLGAVSSA 120

  Fly   149 LAADMYFQDDVIAFIGPACAFALEPVARLA-------AYWNKPIITGMGDQPPSSEGELTVTSGI 206
            |..       |...:||....|..|...||       ..|..|.....|...|:    :|..:..
  Rat   121 LTR-------VSGLVGPVNPAACRPAELLAQEAGVALVPWGCPGTRAAGTTAPA----VTPAADA 174

  Fly   207 LGRIHKWKNENTGMFKDKSKYPTLTRMSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSWT-V 270
            |                           |.          :::.|.|..|||:....:|  |. .
  Rat   175 L---------------------------YV----------LLKAFRWARVALITAPQDL--WVEA 200

  Fly   271 GKNLEYGLRQEGL-----LSFV-KELNGNEEEVYENYLKDASMYARVVILSVRGVLV----RKFM 325
            |:.|...||..||     .|.| .:|:|..|.:  ..::|... .||||:.:..||:    ::::
  Rat   201 GRALSTALRARGLPVALVTSMVPSDLSGAREAL--RRIRDGPR-VRVVIMVMHSVLLGGEEQRYL 262

  Fly   326 L-AAHSLGMTNGEWVFLDVEIFQSEYWGDKGWEMKDE--HDAKARKAYEALLRVSLLQPTSPKFQ 387
            | ||..||:|:|..|||..:..  .|....|.|....  :.:|.|:|::|:|.::...|.....|
  Rat   263 LEAAEELGLTDGSLVFLPFDTL--HYALSPGPEALAAFVNSSKLRRAHDAVLTLTRRCPPGGSVQ 325

  Fly   388 DFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLL-GMALNETLTEGGDIRDGVNITRRMWN 451
            |.....:|:.....:...   ::|:...|..||.|:|| |.........||....|.::.|:|..
  Rat   326 DSLRRAQEHQELPLDLDL---KQVSPLFGTIYDAVFLLAGGVTRARAAVGGGWVSGASVARQMRE 387

  Fly   452 RT---FEGITGH------VRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKKIH 507
            ..   |.||.|.      |.:|.:...:..::...|||:.|            .:.||  |..:|
  Rat   388 AQVFGFCGILGRTEEPSFVLLDTDAAGERLFTTHLLDPVLG------------SLRSA--GTPVH 438

  Fly   508 WPGGREEPPPDVPPCGFLGNSTDCVGNFST---IMYSVFGLLLFLGL--VFLVICLLQKQMKLSK 567
            :|.|...|.|| |.|.|   ..|.:.|...   :::..|.|::.:||  .||...|..:
  Rat   439 FPRGAPAPGPD-PSCWF---DPDVICNGGVEPGLVFVGFLLVIVVGLTGAFLAHYLRHR------ 493

  Fly   568 ELNNMSWRVRPDDVLIEMGGM--FGSKGGLQRLDVENISLQQFGIHSGRA--SIASFTSLP--PQ 626
             |.:|.....|:.:::.:..:  ...:||..|...:       |..|..|  |.:...|:|  ||
  Rat   494 -LLHMQMVSGPNKIILTLEDVTFLHPQGGSSRKVAQ-------GSRSSLATRSTSDIRSVPSQPQ 550

  Fly   627 VYTTIGQFKGERVAIKKV-NVKKVDLTPQLLWEIKQARDVSHENTVRFVGACI----DLP----R 682
            ..|.||.::|:.|.:||. ....:.:.|.......:.|::.|||...::|..:    |.|    .
  Rat   551 ESTNIGLYEGDWVWLKKFPGEHHMAIRPATKMAFSKLRELRHENVALYLGLFLAGTADSPATPGE 615

  Fly   683 PTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGKLRSCNCLIDG 747
            ..:.:::|:|:||||.|:|....|:|||.|:.||:.|::|||.|||:..| |||:|:|.||::||
  Rat   616 GILAVVSEHCARGSLHDLLAQRDIKLDWMFKSSLLLDLIKGMRYLHHRGV-AHGRLKSRNCVVDG 679

  Fly   748 RFVLKISDFG-------LRTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQR-----G 800
            |||||::|.|       .|.|..|.. ..||      ||.|||||.       .||.:|     |
  Rat   680 RFVLKVTDHGHGRLLEAQRVLPEPPS-AEDQ------LWTAPELLR-------DPALERRGTLAG 730

  Fly   801 DVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQ----CNGFRPLIRERECPPDLLELMEKC 861
            ||:|.|||::|:|.|..||  |..::....::.:||.    |   |||:...:.|.:.::||.:|
  Rat   731 DVFSLGIIMQEVVCRSTPY--AMLELTPEEVIQRVRSPPPLC---RPLVSMDQAPMECIQLMAQC 790

  Fly   862 WADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLVEEKTRQLSLEKQRTEEL 926
            ||::.|.||:........:.|.||...|::|.:|..:|||::|||.|:.|:|.:|..|||:|:.|
  Rat   791 WAEHPELRPSMDLTFDLFKGINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRL 855

  Fly   927 LYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFLNDLYSTFDRIIG 991
            |.|:||..||:.|..|..||||.|..||:|||||||||.:.|.|.|::||:.|||||:.||.|||
  Rat   856 LTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIG 920

  Fly   992 FYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPEYKIQIRIGMHSG 1056
            .:||||||||||||:|.||||:.||.:||.|||.|:||||.||.||.:||.||..::||||:|||
  Rat   921 SHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSG 985

  Fly  1057 SVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFGT-FQMEQRGDVELKG 1120
            ...|||||..||.||||||||||||||||||.|.:|||:.:|..||..... ||||.||..||||
  Rat   986 PCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQGFQMECRGRTELKG 1050

  Fly  1121 KGTVTTYWL-NSTSEGEARPPTPQI--------LTTDEVP 1151
            ||...|||| ......:..|..|.:        ::..|:|
  Rat  1051 KGVEDTYWLVGRVGFNKPIPKPPDLQPGASNHGISLQEIP 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368	103/440 (23%)
		ANF_receptor	107..479	CDD:279440	93/406 (23%)
		PKc_like	616..885	CDD:304357	103/295 (35%)
		TyrKc	627..877	CDD:197581	97/274 (35%)
		HNOBA	<882..939	CDD:285003	27/56 (48%)
		CYCc	918..1109	CDD:214485	120/191 (63%)
		Guanylate_cyc	945..1131	CDD:278633	123/187 (66%)
Gucy2d	NP_077356.1	PBP1_sensory_GC_DEF-like	58..434	CDD:380594	105/447 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..552		11/38 (29%)
		PK_GC-2D	540..814	CDD:270945	102/293 (35%)
		HNOBA	<823..868	CDD:400168	22/44 (50%)
		CYCc	848..1039	CDD:214485	120/190 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1069..1108		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820