Protein Alignment CG3216 and Gucy2g

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_001074545.1
• Gene: Gucy2g / 73707
• MGIID: 106025
• Length: 1100
• Species: Mus musculus
• Alignment Length: 1150
• Identity: 355/1150 - (30%)
• Similarity: 569/1150 - (49%)
• Gaps: 105/1150 - (9%)

  Fly    47 LAGLNASDAGLEQRMYERSRESKSTQLSRYTEVGEMGSTMRV-------YNVGVLMASHLDSPFD 104
            :|....|::.||.|:|    ....::....:.|..:...|.|       ..||.....::..||.
Mouse     1 MASRTRSESPLEPRLY----AGAGSRADHPSLVLMLSVVMLVTCLEAAKLTVGFHAPWNISHPFS 61

  Fly   105 LERCGPAVDLALDEINKVFLKPHNITLLKKKGSY--PSCSGARAPGLAADMYFQDDVIAFIGPAC 167
            ::|.|..:...:|::|.   :|..:..:..:.:|  .:||...:..:..|...::.:.|..||||
Mouse    62 VQRLGAGLQTVVDKLNS---EPVGLGNVSWEFTYTNSTCSAKESLAVFIDQVQKEHISALFGPAC 123

  Fly   168 AFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGILGRIHKWKNENTGMFKDKSKYPTLTR 232
            ..|.|.:..||:.||.|:...:|......:             |.|.:....:...|.:...:.|
Mouse   124 PEAAEVIGLLASEWNIPLFDFVGQMAALKD-------------HFWCDTCVTLVPPKQEISAVLR 175

  Fly   233 MSYCQCRLILVFASVIRQFNWNHVALLVDRSELFSWTVGKNLEYGLRQEGL-----LSFVKELNG 292
            .|             :|...|.|:.:....|...||.....: :|..::||     ::.....|.
Mouse   176 ES-------------LRYLGWEHIGVFGGSSADSSWEQVDEM-WGAVEDGLQFHFNITASMRYNS 226

  Fly   293 NEEEVYENYLKDASMYARVVILSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQSEYWGDKGWE 357
            :..::.:..|::.|..|||:||.......|:.:.||..||:..||:||:.::..:..:|.:   .
Mouse   227 SSSDLLQEGLRNMSYVARVIILICSSEDARRILQAAVDLGLDTGEFVFILLQQLEDSFWKE---V 288

  Fly   358 MKDEHDAKARKAYEALLRVSLLQPTSPKFQDFADNVRENALYD-----YNYTFGEGEEVNFFIGA 417
            :..:...:..|.||:   |.|:.|::.......|..|:....:     :..:....::|:.:...
Mouse   289 LTKDKVIRFPKVYES---VFLIAPSAYGGGIGDDGFRKQVSQELRRPPFQSSITSEDQVSPYSAY 350

  Fly   418 FYDGVYLLGMALNETLTEGGDIRDGVNI--TRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDP 480
            .:|.:.|....:.|......|.|||..:  |.|....|.:||||.|.:|..|.|..|||:..|..
Mouse   351 LHDALLLYAQTVEEMRKAEKDFRDGRQLISTLRAGQVTLQGITGPVLLDSQGKRHVDYSVYALQE 415

  Fly   481 INGK--FSVVAHYSGVHKVYSA-VHGKKIHWPGGREEPPPDVPPCGFLGN----STDCVGNFSTI 538
            ...:  |....||....||... .:.....||.|  ..|...|.|||..:    ....|...:..
Mouse   416 SGNRSLFLPFLHYDSFQKVIRPWRNDSNTSWPHG--SLPEYKPGCGFHNDLCKTKPPTVAGMTVT 478

  Fly   539 MYSVFGLLLFLGLVFLV----ICLLQKQMKLSKELNNMSWRVRPDDVLIEMGGMFGSKG-GLQRL 598
            :.:|...:.||.|....    :.|.:.:.|:.....:..|::|.|.:.:........:| .:.|.
Mouse   479 VTAVIPTVTFLVLASAAAITGLMLWRLRGKVQSHPGDTWWQIRYDSITLLPQHKLSHRGTPVSRR 543

  Fly   599 DVENISLQQFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKVN------VKKVDLTPQLLW 657
            :|.:.|..:.....|  |:..........:..:|.::|.:||:..:.      |||    |.:..
Mouse   544 NVSDTSTVKASADCG--SLVKRHQDEELFFAPVGLYQGNQVALCYIGDEAEAWVKK----PTVRR 602

  Fly   658 EIKQARDVSHENTVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVK 722
            |:....::.|||.|.|.|.|.:  .|.:.|:|:||.:|||:||:.|...|:||.|::|..:|||.
Mouse   603 EVCLMCELKHENIVPFFGVCTE--PPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSFAYDIVN 665

  Fly   723 GMNYLHNSDVAAHGKLRSCNCLIDGRFVLKISDFGL---RTLTTPSDFVRDQNYYLKLLWIAPEL 784
            |:.:||.|.:.:||.|:..|||:|....||:|.|||   :..:|...:.::...:.:|.|.||||
Mouse   666 GLLFLHGSPLRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEATDHSELYWTAPEL 730

  Fly   785 LPLTTIPGCCPATQRGDVYSFGIILEEIVNR--GGPYQEARQQMDVHTILHKVRQCNG---FRPL 844
            |.|...|  |..|.:||||||.|:|.:::::  .||:::.....:  .|:.:::....   .||.
Mouse   731 LRLRESP--CSGTPQGDVYSFAILLRDLIHQQAHGPFEDLEAAPE--EIISRIKDPRAPVPLRPS 791

  Fly   845 IRERECPPDLLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYANNLESLV 909
            :.|.:....::.|:.:||.::.|.||.|.:|:..:|........:::|.::.::|.|||:||.:|
Mouse   792 LLEDKGDGRIVALVRECWDESPELRPIFPSIKKTLREASPRGHVSILDSMMGKLETYANHLEEVV 856

  Fly   910 EEKTRQLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMD 974
            ||:||:|..||::.|:||..:||..|.:||:||..||||.|.||||:||||||||:||:.|||:.
Mouse   857 EERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQ 921

  Fly   975 VVNFLNDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNL 1039
            ||..||||||.||..|..:||||||||||||:|.||||..||.:||.|||.|||.:|...:.|.:
Mouse   922 VVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSVTTHFQI 986

  Fly  1040 RHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDK 1104
            .|.||.::::|||:|:|.|.|||||..||.|||||||||.||||||:..|.:||||.:|...|..
Mouse   987 GHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLA 1051

  Fly  1105 FGTFQMEQRGDVELKGKGTVTTYWLNSTSEGEARPPTPQILTTDE 1149
            .|.:.:::||.:.:||||..||:||    :|:...|.|....|:|
Mouse  1052 AGGYHLQKRGTISVKGKGEQTTFWL----KGKDGFPVPLPEFTEE 1092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575	94/427 (22%)
		Protein Kinases, catalytic domain	616..885	CDD:473864	88/282 (31%)
		HNOBA	<891..939	CDD:462234	21/47 (45%)
		CYCc	918..1109	CDD:214485	113/190 (59%)
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595	94/424 (22%)
		PK_GC	555..829	CDD:270894	89/285 (31%)
		CYCc	865..1055	CDD:214485	113/189 (60%)