Protein Alignment CG3216 and gucy2ca

DIOPT Version :10

• Sequence 1: NP_726013.2
• Gene: CG3216 / 37376
• FlyBaseID: FBgn0034568
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: XP_073799927.1
• Gene: gucy2ca / 572052
• ZFINID: ZDB-GENE-091118-67
• Length: 1071
• Species: Danio rerio
• Alignment Length: 1139
• Identity: 341/1139 - (29%)
• Similarity: 519/1139 - (45%)
• Gaps: 250/1139 - (21%)

  Fly    91 VGVLMASHLDSPFDLERCGPAVDLALDEIN------------KVFLKPHNITLLKKKGSYPSCSG 143
            :.|::....:||:.|:.....|:.|:::.|            ||.....|.|..:::|.  ..|.
Zfish    32 LNVVLLEDENSPWSLKFVKDVVETAVEDQNNKNHAEGLDFHIKVLFSGFNTTHYRRRGC--GSST 94

  Fly   144 ARAPGLAADMYFQDDV-IAFIGPACAFALEPVARLAAYWNKPIITGMGDQPPSSEGELTVTSGIL 207
            ..|..:...::...:: ...:||:|.:|...:.               ||    |..||:|..|:
Zfish    95 CEAVEILKSLHNNSELGCVMLGPSCTYATFQLV---------------DQ----EVGLTLTIPII 140

  Fly   208 GRIHKWKNENTGMFKDKSKY-PTLTRMSYCQCRLILVF------------------ASVIRQFNW 253
                     :.|.|.....| ..|||: ....|.|..|                  |.|.::.|:
Zfish   141 ---------SAGSFGLSCDYKQKLTRL-LPPARKIAEFFFHFWHTSVKNLKPAWKTAYVYKKDNY 195

  Fly   254 N-----HVALLVDRSELFSWTVGKNLEYGLRQEGLLSFVKELNGNEEEVYENYLKDASMYARVVI 313
            .     ::..|...|.|||..:.:.:   ||.|..||              ..||....::.:::
Zfish   196 TEECFWYINALEAPSALFSSNISREM---LRSESELS--------------TALKRKDRHSNIIV 243

  Fly   314 LSVRGVLVRKFMLAAHSLGMTNGEWVFLDVEIFQSEYWGDKGWEMKDEHDAKARKAYEALLRVSL 378
            :.  |.....:.:..::  ....:.||:.::::      ::|:...:...|..|         ::
Zfish   244 MC--GTPDDIYTIKKNN--TVPSQVVFILIDLY------NEGYRTNESSPAHMR---------NV 289

  Fly   379 LQPTSPKFQDFADNVRENALYDYNYTFGEGEEVNFFIGAFYDGVYLLGMALNETL---TEGGDIR 440
            |..|...|::::    .|:::..|.|     .:|.::..::|.|.|.|.|:...|   .:...:.
Zfish   290 LVLTMHSFRNYS----SNSVWRNNTT-----ALNDYVVGYHDAVVLFGNAMRNNLQRIKQQQGLS 345

  Fly   441 DGVNITRRMWNRTFEGITGHVRIDDNGDRDADYSILDLDPINGKFSVVAHYSGVHKVYSAVHGKK 505
            |  ||.....|.:|.||.|:.::|.:||||.:.|::   ...|.:.    |..:....::.:..|
Zfish   346 D--NIDPPFRNMSFYGIGGYYKLDSSGDRDLNLSVV---YTTGSYK----YRTLFSFDTSQNRTK 401

  Fly   506 IHWPGGREEPPPDVP-PCGFLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVICLLQK------QM 563
            :      ::..||:| ....|............||..|.||.:.|..|...|...|.      |.
Zfish   402 V------KDSSPDLPWDRSQLPRDKHTGMEIQEIMMIVLGLSVVLATVIAFILYRQNRRVRFDQK 460

  Fly   564 KLS------------KELNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQQFGIHSGRAS 616
            |.|            ||.|.:|..:..|           .||       :|.||    |..||
Zfish   461 KWSHISSSLITPLDDKERNYISLTIDED-----------KKG-------DNSSL----IRKGR-- 501

  Fly   617 IASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHENTVRFVGA----C 677
                             :..:.|.:|::.....:.|.....|:.....:.:.|..:|.|.    |
Zfish   502 -----------------YDKKPVILKELRNTDGNFTDDQRIELNALLRIDYYNLTKFYGTVRFDC 549

  Fly   678 IDLPRPTVLILTEYCSRGSLKDVLEN-----EAIELDWNFRMSLIHDIVKGMNYLHNSDVAAHGK 737
                  .|..:.|:|.||||:.||::     :|..:|..||:|:::||.|||:|||:|:|..||:
Zfish   550 ------GVFGVFEFCERGSLRYVLDDKISYPDASFMDLEFRISVMYDIAKGMSYLHSSNVGVHGR 608

  Fly   738 LRSCNCLIDGRFVLKISDFGLRTLTTPSDFVRDQNYYLKLLWIAPELLPLTTIPGCCPATQRGDV 802
            |:|.||::|.|.|:||:|||..|:.:|.          |.||.|||.:.:..|      :|:|||
Zfish   609 LKSTNCVVDNRMVVKITDFGCNTILSPG----------KDLWTAPEHMRVEGI------SQKGDV 657

  Fly   803 YSFGIILEEIVNRGGPYQEARQQMDVHT-----------ILHKVRQCNGFRPLIRER---ECPPD 853
            |||.||.:||:.|..|:         ||           ::...|..|.|||.:...   |...:
Zfish   658 YSFAIISQEIILRKSPF---------HTSCCSDMAEKLYLVQYPRGPNVFRPDLSFEGVGETEAE 713

  Fly   854 LLELMEKCWADNQEERPTFSTIRSNIRTIMKGFCE----NLMDDLLNRMEQYANNLESLVEEKTR 914
            |..|::.||.::.|:||.|..|...:..|......    :.||:|:.|::.|:.|||.||||:|.
Zfish   714 LFVLIKSCWEEDPEKRPDFKRIEGALGKIFSNLHNQANASYMDNLIRRLQMYSRNLEHLVEERTA 778

  Fly   915 QLSLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDVVNFL 979
            ....|:.|.::|.:.:||.||.:.|.....||||.:..||||||||||||.:|..|:||:||:.|
Zfish   779 LYKAERDRADQLNFMLLPGPVVRSLKETGRVEPELYDEVTIYFSDIVGFTTICHHSTPMEVVDML 843

  Fly   980 NDLYSTFDRIIGFYDVYKVETIGDAYLVVSGLPEPNGDKHAREIALMALDILRAVSSFNLRHKPE 1044
            ||:|..||.|:..:||||||||||||:|.||||..||::||.:|.|||||||..:.:|.|||.|.
Zfish   844 NDIYKNFDSILDHHDVYKVETIGDAYMVASGLPRCNGNRHAVDICLMALDILEFMGTFQLRHLPG 908

  Fly  1045 YKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVNTASRMESTGQPGKIHVSSATKAILDKFG-TF 1108
            ..:.||||:|||...|||||.|||.||||||||||||||||||.|.:||||.:|..||.:.. .|
Zfish   909 IPLWIRIGIHSGPCAAGVVGNKMPRYCLFGDTVNTASRMESTGLPLRIHVSESTIKILQRTDCEF 973

  Fly  1109 QMEQRGDVELKGKGTVTTYWLNSTSEGEARPPTP 1142
            :.|:||:..|||||...||||...:..:...|||
Zfish   974 ECERRGETFLKGKGKEMTYWLTGVTGQKYSLPTP 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3216	NP_726013.2	PBP1_NPR_GC-like	90..501	CDD:380575	84/449 (19%)
		Protein Kinases, catalytic domain	616..885	CDD:473864	86/291 (30%)
		HNOBA	<891..939	CDD:462234	20/47 (43%)
		CYCc	918..1109	CDD:214485	112/191 (59%)
gucy2ca	XP_073799927.1	None